A novel injectable borate bioactive glass cement for local delivery of vancomycin to cure osteomyelitis and regenerate bone

Osteomyelitis (bone infection) is often difficult to cure. The commonly-used treatment of surgical debridement to remove the infected bone combined with prolonged systemic and local antibiotic treatment has limitations. In the present study, an injectable borate bioactive glass cement was developed...

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Veröffentlicht in:	Journal of materials science. Materials in medicine 2014-03, Vol.25 (3), p.733-745
Hauptverfasser:	Cui, Xu, Zhao, Cunju, Gu, Yifei, Li, Le, Wang, Hui, Huang, Wenhai, Zhou, Nai, Wang, Deping, Zhu, Yi, Xu, Jun, Luo, Shihua, Zhang, Changqing, Rahaman, Mohamed N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Biological activity Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone Cements - chemistry Bone Cements - therapeutic use Bone Regeneration - drug effects Bones Borates - chemistry Ceramics Chemistry and Materials Science Composites Compressive Strength Drug Carriers - administration & dosage Drug Carriers - chemistry Drug delivery systems Female Glass Glass - chemistry Injections, Intralesional Materials Science Materials Testing Medical sciences Natural Materials Osteomyelitis - therapy Pharmacology. Drug treatments Polymer Sciences Rabbits Regenerative Medicine/Tissue Engineering Staphylococcus aureus Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films Tibia Tissue engineering Vancomycin - administration & dosage Vancomycin - chemistry
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