A controlled release of antibiotics from calcium phosphate-coated poly(lactic-co-glycolic acid) particles and their in vitro efficacy against Staphylococcus aureus biofilm
Ceramic-polymer hybrid particles, intended for osteomyelitis treatment, were fabricated by preparing poly(lactic- co -glycolic acid) particles through an emulsion solvent evaporation technique, followed by calcium phosphate (CaP) coating via a surface adsorption-nucleation method. The presence of Ca...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2014-03, Vol.25 (3), p.747-757 |
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| container_title | Journal of materials science. Materials in medicine |
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| creator | Bastari, Kelsen Arshath, Mohamed NG, Zhi Hui Melissa Chia, Jia Hua Yow, Zhi Xian Daniel Sana, Barindra Tan, Meng Fong Cherine Lim, Sierin Loo, Say Chye Joachim |
| description | Ceramic-polymer hybrid particles, intended for osteomyelitis treatment, were fabricated by preparing poly(lactic-
co
-glycolic acid) particles through an emulsion solvent evaporation technique, followed by calcium phosphate (CaP) coating via a surface adsorption-nucleation method. The presence of CaP coating on the surface of the particles was confirmed by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Subsequently, two antibiotics for treating bone infection, nafcillin (hydrophilic) and levofloxacin (amphiphilic), were loaded into these hybrid particles and their in vitro drug release studies were investigated. The CaP coating was shown to reduce burst release, while providing sustained release of the antibiotics for up to 4 weeks. In vitro bacterial study against
Staphylococcus aureus
demonstrated the capability of these antibiotic-loaded hybrid particles to inhibit biofilm formation as well as deteriorate established biofilm, making this hybrid system a potential candidate for further investigation for osteomyelitis treatment. |
| doi_str_mv | 10.1007/s10856-013-5125-9 |
| format | Article |
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co
-glycolic acid) particles through an emulsion solvent evaporation technique, followed by calcium phosphate (CaP) coating via a surface adsorption-nucleation method. The presence of CaP coating on the surface of the particles was confirmed by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Subsequently, two antibiotics for treating bone infection, nafcillin (hydrophilic) and levofloxacin (amphiphilic), were loaded into these hybrid particles and their in vitro drug release studies were investigated. The CaP coating was shown to reduce burst release, while providing sustained release of the antibiotics for up to 4 weeks. In vitro bacterial study against
Staphylococcus aureus
demonstrated the capability of these antibiotic-loaded hybrid particles to inhibit biofilm formation as well as deteriorate established biofilm, making this hybrid system a potential candidate for further investigation for osteomyelitis treatment.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-013-5125-9</identifier><identifier>PMID: 24370968</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - chemistry ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; Biological and medical sciences ; Biomaterials ; Biomedical engineering ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Bone diseases ; Bones ; Calcium Phosphates - chemistry ; Cell Survival ; Cellular ceramic materials ; Ceramics ; Chemistry and Materials Science ; Composites ; Delayed-Action Preparations - administration & dosage ; Delayed-Action Preparations - chemistry ; Diffusion ; Glass ; Materials Science ; Medical sciences ; Nanocapsules - administration & dosage ; Nanocapsules - chemistry ; Nanocapsules - ultrastructure ; Natural Materials ; Particle Size ; Pharmacology. Drug treatments ; Polyglycolic Acid - analogs & derivatives ; Polyglycolic Acid - chemistry ; Polymer blends ; Polymer Sciences ; Regenerative Medicine/Tissue Engineering ; Scanning electron microscopy ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - physiology ; Surfaces and Interfaces ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Thin Films</subject><ispartof>Journal of materials science. Materials in medicine, 2014-03, Vol.25 (3), p.747-757</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-36cceb1f24c7e04319e05f620ddee28eef48f471da55e476c0b33d4f7491f8493</citedby><cites>FETCH-LOGICAL-c435t-36cceb1f24c7e04319e05f620ddee28eef48f471da55e476c0b33d4f7491f8493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-013-5125-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-013-5125-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28565403$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24370968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bastari, Kelsen</creatorcontrib><creatorcontrib>Arshath, Mohamed</creatorcontrib><creatorcontrib>NG, Zhi Hui Melissa</creatorcontrib><creatorcontrib>Chia, Jia Hua</creatorcontrib><creatorcontrib>Yow, Zhi Xian Daniel</creatorcontrib><creatorcontrib>Sana, Barindra</creatorcontrib><creatorcontrib>Tan, Meng Fong Cherine</creatorcontrib><creatorcontrib>Lim, Sierin</creatorcontrib><creatorcontrib>Loo, Say Chye Joachim</creatorcontrib><title>A controlled release of antibiotics from calcium phosphate-coated poly(lactic-co-glycolic acid) particles and their in vitro efficacy against Staphylococcus aureus biofilm</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Ceramic-polymer hybrid particles, intended for osteomyelitis treatment, were fabricated by preparing poly(lactic-
co
-glycolic acid) particles through an emulsion solvent evaporation technique, followed by calcium phosphate (CaP) coating via a surface adsorption-nucleation method. The presence of CaP coating on the surface of the particles was confirmed by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Subsequently, two antibiotics for treating bone infection, nafcillin (hydrophilic) and levofloxacin (amphiphilic), were loaded into these hybrid particles and their in vitro drug release studies were investigated. The CaP coating was shown to reduce burst release, while providing sustained release of the antibiotics for up to 4 weeks. In vitro bacterial study against
Staphylococcus aureus
demonstrated the capability of these antibiotic-loaded hybrid particles to inhibit biofilm formation as well as deteriorate established biofilm, making this hybrid system a potential candidate for further investigation for osteomyelitis treatment.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical engineering</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Bone diseases</subject><subject>Bones</subject><subject>Calcium Phosphates - chemistry</subject><subject>Cell Survival</subject><subject>Cellular ceramic materials</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Delayed-Action Preparations - administration & dosage</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Diffusion</subject><subject>Glass</subject><subject>Materials Science</subject><subject>Medical sciences</subject><subject>Nanocapsules - administration & dosage</subject><subject>Nanocapsules - chemistry</subject><subject>Nanocapsules - ultrastructure</subject><subject>Natural Materials</subject><subject>Particle Size</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyglycolic Acid - analogs & derivatives</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Polymer blends</subject><subject>Polymer Sciences</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Scanning electron microscopy</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - physiology</subject><subject>Surfaces and Interfaces</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bastari, Kelsen</au><au>Arshath, Mohamed</au><au>NG, Zhi Hui Melissa</au><au>Chia, Jia Hua</au><au>Yow, Zhi Xian Daniel</au><au>Sana, Barindra</au><au>Tan, Meng Fong Cherine</au><au>Lim, Sierin</au><au>Loo, Say Chye Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A controlled release of antibiotics from calcium phosphate-coated poly(lactic-co-glycolic acid) particles and their in vitro efficacy against Staphylococcus aureus biofilm</atitle><jtitle>Journal of materials science. 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co
-glycolic acid) particles through an emulsion solvent evaporation technique, followed by calcium phosphate (CaP) coating via a surface adsorption-nucleation method. The presence of CaP coating on the surface of the particles was confirmed by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Subsequently, two antibiotics for treating bone infection, nafcillin (hydrophilic) and levofloxacin (amphiphilic), were loaded into these hybrid particles and their in vitro drug release studies were investigated. The CaP coating was shown to reduce burst release, while providing sustained release of the antibiotics for up to 4 weeks. In vitro bacterial study against
Staphylococcus aureus
demonstrated the capability of these antibiotic-loaded hybrid particles to inhibit biofilm formation as well as deteriorate established biofilm, making this hybrid system a potential candidate for further investigation for osteomyelitis treatment.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24370968</pmid><doi>10.1007/s10856-013-5125-9</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of materials science. Materials in medicine, 2014-03, Vol.25 (3), p.747-757 |
| issn | 0957-4530 1573-4838 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biofilms Biofilms - drug effects Biofilms - growth & development Biological and medical sciences Biomaterials Biomedical engineering Biomedical Engineering and Bioengineering Biomedical materials Bone diseases Bones Calcium Phosphates - chemistry Cell Survival Cellular ceramic materials Ceramics Chemistry and Materials Science Composites Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Diffusion Glass Materials Science Medical sciences Nanocapsules - administration & dosage Nanocapsules - chemistry Nanocapsules - ultrastructure Natural Materials Particle Size Pharmacology. Drug treatments Polyglycolic Acid - analogs & derivatives Polyglycolic Acid - chemistry Polymer blends Polymer Sciences Regenerative Medicine/Tissue Engineering Scanning electron microscopy Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films |
| title | A controlled release of antibiotics from calcium phosphate-coated poly(lactic-co-glycolic acid) particles and their in vitro efficacy against Staphylococcus aureus biofilm |
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