Polycystic Kidney Disease: A Case of Suppressed Autophagy?

Summary Autosomal-dominant polycystic kidney disease is the most common form of polycystic kidney disease in adults and is caused by a mutation in the polycystic kidney disease 1 or 2 genes, which encode, respectively, polycystin-1 and polycystin-2. Autophagy is present in polycystic kidneys in rat...

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Veröffentlicht in:	Seminars in nephrology 2014, Vol.34 (1), p.27-33
Hauptverfasser:	Ravichandran, Kameswaran, PhD, Edelstein, Charles L., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis autophagy Autophagy - physiology Cilia - physiology Humans Mice Nephrology Polycystic kidney Polycystic Kidney Diseases - etiology Polycystic Kidney Diseases - pathology Proteins - physiology Signal Transduction
Online-Zugang:	Volltext
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