The effects of pH on wound healing, biofilms, and antimicrobial efficacy
It is known that pH has a role to play in wound healing. In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses i...
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Veröffentlicht in: | Wound repair and regeneration 2014-03, Vol.22 (2), p.174-186 |
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creator | Percival, Steven L. McCarty, Sara Hunt, John A. Woods, Emma J. |
description | It is known that pH has a role to play in wound healing. In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses in a wound; the patient's defense mechanisms change the local pH of a wound to effect microorganism invasion and proliferation; this pH change has been found to affect the performance of antimicrobials, and therefore the efficacy in biological environments directly relevant to wound healing. Based on the available body of scientific evidence to date, it is clear that pH has a role to play in both the healing of and treatment of chronic and acute wounds. It is the purpose of this review to evaluate the published knowledge base that concerns the effect of pH changes, the role it plays in wound healing and biofilm formation, and how it can affect treatment efficacy and wound management strategies. |
doi_str_mv | 10.1111/wrr.12125 |
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In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses in a wound; the patient's defense mechanisms change the local pH of a wound to effect microorganism invasion and proliferation; this pH change has been found to affect the performance of antimicrobials, and therefore the efficacy in biological environments directly relevant to wound healing. Based on the available body of scientific evidence to date, it is clear that pH has a role to play in both the healing of and treatment of chronic and acute wounds. 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In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses in a wound; the patient's defense mechanisms change the local pH of a wound to effect microorganism invasion and proliferation; this pH change has been found to affect the performance of antimicrobials, and therefore the efficacy in biological environments directly relevant to wound healing. Based on the available body of scientific evidence to date, it is clear that pH has a role to play in both the healing of and treatment of chronic and acute wounds. It is the purpose of this review to evaluate the published knowledge base that concerns the effect of pH changes, the role it plays in wound healing and biofilm formation, and how it can affect treatment efficacy and wound management strategies.</description><subject>Anti-Infective Agents - administration & dosage</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Cell Proliferation</subject><subject>Fibroblasts</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lymphocytes</subject><subject>Macrophages</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - metabolism</subject><subject>Wound Healing - drug effects</subject><subject>Wound Infection - drug therapy</subject><subject>Wound Infection - metabolism</subject><subject>Wound Infection - microbiology</subject><subject>Wound Infection - physiopathology</subject><subject>Wounds and Injuries - drug therapy</subject><subject>Wounds and Injuries - metabolism</subject><subject>Wounds and Injuries - physiopathology</subject><issn>1067-1927</issn><issn>1524-475X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0E4lFY8AMoS5AaGDt2nCxRBS0IgaiK6M6yHZsa8ihxq9K_x6WPHbOZ0ejcO6OL0DmGaxzqZtG215hgwvbQMWaExpSz8X6YIeUxzgk_QifefwIAY3l2iI4ITTHOMzhGg9HERMZao2c-amw0HURNHS2aeV1EEyNLV390I-Ua68rKdyMZ1rKeucrptlFOliut01IvT9GBlaU3Z5veQW_3d6PeIH566T_0bp9inQJlscwBE6IYzYGrnOaWF1pBOF9ojtNUZQYgwVYV2oChVHJOMpNiyBJrFec06aDLte-0bb7nxs9E5bw2ZSlr08y9wAyyNANO8oBerdHwq_etsWLaukq2S4FBrIITITjxF1xgLza2c1WZYkdukwrAzRpYuNIs_3cS78Ph1jJeK5yfmZ-dQrZfIuUJD-RzX4yzUX_8yIbiNfkFA7yF9w</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Percival, Steven L.</creator><creator>McCarty, Sara</creator><creator>Hunt, John A.</creator><creator>Woods, Emma J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>The effects of pH on wound healing, biofilms, and antimicrobial efficacy</title><author>Percival, Steven L. ; McCarty, Sara ; Hunt, John A. ; Woods, Emma J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6045-a90122b54907b949f7dcb0fecdc7166b8e0031fbdce0e44a7728e61083ffb7743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Anti-Infective Agents - administration & dosage</topic><topic>Biofilms - drug effects</topic><topic>Biofilms - growth & development</topic><topic>Cell Proliferation</topic><topic>Fibroblasts</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Lymphocytes</topic><topic>Macrophages</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - metabolism</topic><topic>Wound Healing - drug effects</topic><topic>Wound Infection - drug therapy</topic><topic>Wound Infection - metabolism</topic><topic>Wound Infection - microbiology</topic><topic>Wound Infection - physiopathology</topic><topic>Wounds and Injuries - drug therapy</topic><topic>Wounds and Injuries - metabolism</topic><topic>Wounds and Injuries - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Percival, Steven L.</creatorcontrib><creatorcontrib>McCarty, Sara</creatorcontrib><creatorcontrib>Hunt, John A.</creatorcontrib><creatorcontrib>Woods, Emma J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Wound repair and regeneration</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Percival, Steven L.</au><au>McCarty, Sara</au><au>Hunt, John A.</au><au>Woods, Emma J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of pH on wound healing, biofilms, and antimicrobial efficacy</atitle><jtitle>Wound repair and regeneration</jtitle><addtitle>Wound Repair Regen</addtitle><date>2014-03</date><risdate>2014</risdate><volume>22</volume><issue>2</issue><spage>174</spage><epage>186</epage><pages>174-186</pages><issn>1067-1927</issn><eissn>1524-475X</eissn><abstract>It is known that pH has a role to play in wound healing. 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subjects | Anti-Infective Agents - administration & dosage Biofilms - drug effects Biofilms - growth & development Cell Proliferation Fibroblasts Humans Hydrogen-Ion Concentration Lymphocytes Macrophages Matrix Metalloproteinases - metabolism Tissue Inhibitor of Metalloproteinase-1 - metabolism Wound Healing - drug effects Wound Infection - drug therapy Wound Infection - metabolism Wound Infection - microbiology Wound Infection - physiopathology Wounds and Injuries - drug therapy Wounds and Injuries - metabolism Wounds and Injuries - physiopathology |
title | The effects of pH on wound healing, biofilms, and antimicrobial efficacy |
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