The effects of pH on wound healing, biofilms, and antimicrobial efficacy

It is known that pH has a role to play in wound healing. In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses i...

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Veröffentlicht in:Wound repair and regeneration 2014-03, Vol.22 (2), p.174-186
Hauptverfasser: Percival, Steven L., McCarty, Sara, Hunt, John A., Woods, Emma J.
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container_end_page 186
container_issue 2
container_start_page 174
container_title Wound repair and regeneration
container_volume 22
creator Percival, Steven L.
McCarty, Sara
Hunt, John A.
Woods, Emma J.
description It is known that pH has a role to play in wound healing. In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses in a wound; the patient's defense mechanisms change the local pH of a wound to effect microorganism invasion and proliferation; this pH change has been found to affect the performance of antimicrobials, and therefore the efficacy in biological environments directly relevant to wound healing. Based on the available body of scientific evidence to date, it is clear that pH has a role to play in both the healing of and treatment of chronic and acute wounds. It is the purpose of this review to evaluate the published knowledge base that concerns the effect of pH changes, the role it plays in wound healing and biofilm formation, and how it can affect treatment efficacy and wound management strategies.
doi_str_mv 10.1111/wrr.12125
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subjects Anti-Infective Agents - administration & dosage
Biofilms - drug effects
Biofilms - growth & development
Cell Proliferation
Fibroblasts
Humans
Hydrogen-Ion Concentration
Lymphocytes
Macrophages
Matrix Metalloproteinases - metabolism
Tissue Inhibitor of Metalloproteinase-1 - metabolism
Wound Healing - drug effects
Wound Infection - drug therapy
Wound Infection - metabolism
Wound Infection - microbiology
Wound Infection - physiopathology
Wounds and Injuries - drug therapy
Wounds and Injuries - metabolism
Wounds and Injuries - physiopathology
title The effects of pH on wound healing, biofilms, and antimicrobial efficacy
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