Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients
Current evidence suggests that regenerative v. degenerative endothelial responses can be integrated in a clinical endothelial phenotype, reflecting the net result between damage from risk factors and endogenous repair capacity. We have previously shown that a cocoa flavanol (CF) intervention can imp...
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| Veröffentlicht in: | British journal of nutrition 2014-04, Vol.111 (7), p.1245-1252 |
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| creator | Horn, Patrick Amabile, Nicolas Angeli, Franca S. Sansone, Roberto Stegemann, Berthold Kelm, Malte Springer, Matthew L. Yeghiazarians, Yerem Schroeter, Hagen Heiss, Christian |
| description | Current evidence suggests that regenerative v. degenerative endothelial responses can be integrated in a clinical endothelial phenotype, reflecting the net result between damage from risk factors and endogenous repair capacity. We have previously shown that a cocoa flavanol (CF) intervention can improve endothelial function and increase the regenerative capacity of the endothelium by mobilising circulating angiogenic cells in patients with coronary artery disease (CAD). The aim of the present study was to investigate whether CF can lower the levels of circulating endothelial microparticles (EMP), markers of endothelial integrity, along with improvements in endothelial function. The levels of EMP in the frozen plasma samples of CAD patients were measured along with endothelial function (flow-mediated vasodilation, FMD); n 16, FMD data published previously), and these data were compared with those of young (n 12) and age-matched (n 12) healthy control subjects. The CAD patients exhibited significantly increased levels of EMP along with impaired FMD when compared with the healthy control subjects. The levels of CD144+ and CD31+/41− EMP were inversely correlated with FMD (r − 0·67, P= 0·01 and r − 0·59, P= 0·01, respectively). In these CAD patients, the levels of EMP were measured after they had consumed a drink containing 375 mg of CF (high-CF intervention, HiFI) or 9 mg of CF (macro- and micronutrient-matched low-CF control, LoFl) twice daily over a 30-d period in a randomised, double-blind, cross-over study. After 1 month of HiFI, the levels of CD31+/41− and CD144+ EMP decreased ( − 25 and − 23 %, respectively), but not after LoFl. Our data show that flavanols lower the levels of EMP along with higher endothelial function, lending evidence to the novel concept that flavanols may improve endothelial integrity. |
| doi_str_mv | 10.1017/S0007114513003693 |
| format | Article |
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We have previously shown that a cocoa flavanol (CF) intervention can improve endothelial function and increase the regenerative capacity of the endothelium by mobilising circulating angiogenic cells in patients with coronary artery disease (CAD). The aim of the present study was to investigate whether CF can lower the levels of circulating endothelial microparticles (EMP), markers of endothelial integrity, along with improvements in endothelial function. The levels of EMP in the frozen plasma samples of CAD patients were measured along with endothelial function (flow-mediated vasodilation, FMD); n 16, FMD data published previously), and these data were compared with those of young (n 12) and age-matched (n 12) healthy control subjects. The CAD patients exhibited significantly increased levels of EMP along with impaired FMD when compared with the healthy control subjects. The levels of CD144+ and CD31+/41− EMP were inversely correlated with FMD (r − 0·67, P= 0·01 and r − 0·59, P= 0·01, respectively). In these CAD patients, the levels of EMP were measured after they had consumed a drink containing 375 mg of CF (high-CF intervention, HiFI) or 9 mg of CF (macro- and micronutrient-matched low-CF control, LoFl) twice daily over a 30-d period in a randomised, double-blind, cross-over study. After 1 month of HiFI, the levels of CD31+/41− and CD144+ EMP decreased ( − 25 and − 23 %, respectively), but not after LoFl. Our data show that flavanols lower the levels of EMP along with higher endothelial function, lending evidence to the novel concept that flavanols may improve endothelial integrity.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114513003693</identifier><identifier>PMID: 24286443</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Antigens, CD - blood ; Biological and medical sciences ; Biomarkers - blood ; Brachial Artery - diagnostic imaging ; Cacao - chemistry ; Cadherins - blood ; Cardiology. Vascular system ; Cardiovascular disease ; Cell-Derived Microparticles - metabolism ; Cell-Derived Microparticles - pathology ; Coronary Artery Disease - blood ; Coronary Artery Disease - diet therapy ; Coronary Artery Disease - pathology ; Coronary Artery Disease - physiopathology ; Coronary heart disease ; Cross-Over Studies ; Cross-Sectional Studies ; Diet ; Dietary Supplements ; Double-Blind Method ; Endothelium, Vascular - diagnostic imaging ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Feeding. Feeding behavior ; Female ; Flavonols - therapeutic use ; Fruit - chemistry ; Fundamental and applied biological sciences. Psychology ; Heart ; Human and Clinical Nutrition ; Humans ; Intervention ; Male ; Medical sciences ; Middle Aged ; Phytochemicals ; Platelet Endothelial Cell Adhesion Molecule-1 - blood ; Reference Values ; Risk factors ; Ultrasonography ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Young Adult</subject><ispartof>British journal of nutrition, 2014-04, Vol.111 (7), p.1245-1252</ispartof><rights>Copyright © The Authors 2013</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-b37decd599ce976050cea56da237d89355acf82715edfccd1d5fe12393f4da333</citedby><cites>FETCH-LOGICAL-c516t-b37decd599ce976050cea56da237d89355acf82715edfccd1d5fe12393f4da333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114513003693/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28313035$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24286443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horn, Patrick</creatorcontrib><creatorcontrib>Amabile, Nicolas</creatorcontrib><creatorcontrib>Angeli, Franca S.</creatorcontrib><creatorcontrib>Sansone, Roberto</creatorcontrib><creatorcontrib>Stegemann, Berthold</creatorcontrib><creatorcontrib>Kelm, Malte</creatorcontrib><creatorcontrib>Springer, Matthew L.</creatorcontrib><creatorcontrib>Yeghiazarians, Yerem</creatorcontrib><creatorcontrib>Schroeter, Hagen</creatorcontrib><creatorcontrib>Heiss, Christian</creatorcontrib><title>Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Current evidence suggests that regenerative v. degenerative endothelial responses can be integrated in a clinical endothelial phenotype, reflecting the net result between damage from risk factors and endogenous repair capacity. We have previously shown that a cocoa flavanol (CF) intervention can improve endothelial function and increase the regenerative capacity of the endothelium by mobilising circulating angiogenic cells in patients with coronary artery disease (CAD). The aim of the present study was to investigate whether CF can lower the levels of circulating endothelial microparticles (EMP), markers of endothelial integrity, along with improvements in endothelial function. The levels of EMP in the frozen plasma samples of CAD patients were measured along with endothelial function (flow-mediated vasodilation, FMD); n 16, FMD data published previously), and these data were compared with those of young (n 12) and age-matched (n 12) healthy control subjects. The CAD patients exhibited significantly increased levels of EMP along with impaired FMD when compared with the healthy control subjects. The levels of CD144+ and CD31+/41− EMP were inversely correlated with FMD (r − 0·67, P= 0·01 and r − 0·59, P= 0·01, respectively). In these CAD patients, the levels of EMP were measured after they had consumed a drink containing 375 mg of CF (high-CF intervention, HiFI) or 9 mg of CF (macro- and micronutrient-matched low-CF control, LoFl) twice daily over a 30-d period in a randomised, double-blind, cross-over study. After 1 month of HiFI, the levels of CD31+/41− and CD144+ EMP decreased ( − 25 and − 23 %, respectively), but not after LoFl. Our data show that flavanols lower the levels of EMP along with higher endothelial function, lending evidence to the novel concept that flavanols may improve endothelial integrity.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, CD - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Cacao - chemistry</subject><subject>Cadherins - blood</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Cell-Derived Microparticles - pathology</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diet therapy</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Cross-Over Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Endothelium, Vascular - diagnostic imaging</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Feeding. 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We have previously shown that a cocoa flavanol (CF) intervention can improve endothelial function and increase the regenerative capacity of the endothelium by mobilising circulating angiogenic cells in patients with coronary artery disease (CAD). The aim of the present study was to investigate whether CF can lower the levels of circulating endothelial microparticles (EMP), markers of endothelial integrity, along with improvements in endothelial function. The levels of EMP in the frozen plasma samples of CAD patients were measured along with endothelial function (flow-mediated vasodilation, FMD); n 16, FMD data published previously), and these data were compared with those of young (n 12) and age-matched (n 12) healthy control subjects. The CAD patients exhibited significantly increased levels of EMP along with impaired FMD when compared with the healthy control subjects. The levels of CD144+ and CD31+/41− EMP were inversely correlated with FMD (r − 0·67, P= 0·01 and r − 0·59, P= 0·01, respectively). In these CAD patients, the levels of EMP were measured after they had consumed a drink containing 375 mg of CF (high-CF intervention, HiFI) or 9 mg of CF (macro- and micronutrient-matched low-CF control, LoFl) twice daily over a 30-d period in a randomised, double-blind, cross-over study. After 1 month of HiFI, the levels of CD31+/41− and CD144+ EMP decreased ( − 25 and − 23 %, respectively), but not after LoFl. Our data show that flavanols lower the levels of EMP along with higher endothelial function, lending evidence to the novel concept that flavanols may improve endothelial integrity.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>24286443</pmid><doi>10.1017/S0007114513003693</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antigens, CD - blood Biological and medical sciences Biomarkers - blood Brachial Artery - diagnostic imaging Cacao - chemistry Cadherins - blood Cardiology. Vascular system Cardiovascular disease Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - pathology Coronary Artery Disease - blood Coronary Artery Disease - diet therapy Coronary Artery Disease - pathology Coronary Artery Disease - physiopathology Coronary heart disease Cross-Over Studies Cross-Sectional Studies Diet Dietary Supplements Double-Blind Method Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Feeding. Feeding behavior Female Flavonols - therapeutic use Fruit - chemistry Fundamental and applied biological sciences. Psychology Heart Human and Clinical Nutrition Humans Intervention Male Medical sciences Middle Aged Phytochemicals Platelet Endothelial Cell Adhesion Molecule-1 - blood Reference Values Risk factors Ultrasonography Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult |
| title | Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients |
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