Impact of CYP2C19 Polymorphism and Proton Pump Inhibitors on Platelet Reactivity to Clopidogrel and Clinical Outcomes Following Stent Implantation

Abstract Background The response to clopidogrel, and some kind of the drug interaction are multifactorial. Methods and Results We enrolled 174 consecutive patients and determined CYP2C19 genotypes, measured platelet aggregation, and assessed the relationship between CYP2C19 genotype and platelet rea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Thrombosis research 2014-04, Vol.133 (4), p.599-605
Hauptverfasser:	Hokimoto, Seiji, Mizobe, Michio, Akasaka, Tomonori, Arima, Yuichiro, Kaikita, Koichi, Nakagawa, Kazuko, Ogawa, Hisao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood Platelets - drug effects Blood Platelets - enzymology Cardiovascular Diseases - blood Cardiovascular Diseases - enzymology Cardiovascular Diseases - etiology Cardiovascular Diseases - genetics Cytochrome P-450 CYP2C19 - administration & dosage Drug Interactions Female Genotype Hematology, Oncology and Palliative Medicine Humans Male Middle Aged Percutaneous Coronary Intervention - methods Platelet Aggregation - drug effects Platelet Aggregation - genetics Polymorphism, Genetic Rabeprazole - administration & dosage Stents Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!