Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B

Abstract Background Mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) signaling pathways are pleiotropic regulator of many genes involved in lipopolysaccharide (LPS)-induced acute lung injury (ALI). The present study aimed to reveal the protective effect of isotetrandrine...

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Veröffentlicht in:	The Journal of surgical research 2014-04, Vol.187 (2), p.596-604
Hauptverfasser:	Liang, Xian-ming, PhD, Guo, Gui-fang, MD, Huang, Xian-hui, PhD, Duan, Wen-long, PhD, Zeng, Zhen-ling, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Acute Lung Injury - metabolism ALI Animals Benzylisoquinolines - chemistry Benzylisoquinolines - pharmacology Bronchoalveolar Lavage Fluid Cell Line Disease Models, Animal Dose-Response Relationship, Drug Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology Inflammation Interleukin-1beta - metabolism Interleukin-6 - metabolism Isotetrandrine (ITD) Lipopolysaccharides - pharmacology LPS Male Mice Mice, Inbred BALB C Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism Peroxidase - metabolism Pulmonary Edema - chemically induced Pulmonary Edema - drug therapy Pulmonary Edema - metabolism Surgery
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