Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery

Objective Recently, the role of β-blockers (BBs) in reducing perioperative mortality has been challenged. The conflicting results might have resulted from the extent of BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. The purpose of the present study was to assess the association between th...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2014-04, Vol.147 (4), p.1368-1375.e3
Hauptverfasser:	Kertai, Miklos D., MD, PhD, Esper, Stephen A., MD, MBA, Akushevich, Igor, PhD, Voora, Deepak, MD, Ginsburg, Geoffrey S., MD, PhD, Stafford-Smith, Mark, MD, Grichnik, Katherine, MD, Newman, Mark F., MD, Fontes, Manuel L., MD, Smith, Peter, MD, Podgoreanu, Mihai V., MD, Mathew, Joseph P., MD, MHSc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - metabolism Aged Aged, 80 and over Cardiothoracic Surgery Coronary Artery Bypass - mortality Cytochrome P-450 CYP2D6 - physiology Female Humans Male Middle Aged Preoperative Care Retrospective Studies
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