Role of human papillomavirus infection and other factors in patients with head and neck squamous cell carcinoma
Objective To analyse the association between high‐risk human papillomavirus (HR‐HPV) and other risk factors in the aetiology of head and neck squamous cell carcinoma (HNSCC) in an Asian population. Study Design This study is a cross‐sectional analysis of 80 patients who were diagnosed with HNSCC. Pa...
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| Veröffentlicht in: | Oral diseases 2014-04, Vol.20 (3), p.288-293 |
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| creator | Iqbal, A Warraich, R Udeabor, SE Rana, M Eckardt, AM Gellrich, N-C Rana, M |
| description | Objective
To analyse the association between high‐risk human papillomavirus (HR‐HPV) and other risk factors in the aetiology of head and neck squamous cell carcinoma (HNSCC) in an Asian population.
Study Design
This study is a cross‐sectional analysis of 80 patients who were diagnosed with HNSCC. Patients' demographics, dietary habit, medical and social history were obtained. Surgical specimens from these patients were then histologically analysed using H&E stain and immunohistochemistry (IHC) for the presence of HR‐HPV primary antibody.
Results
High‐risk human papillomavirus was detected in 41 patients, representing 51.3% of the 80 paraffin‐embedded tissues of HNSCC; 27.5% of these were weak positive, 10.0% medium positive and 13.8% were strongly positive for the HR‐HPV on IHC. The tongue lesions had the highest HR‐HPV infection of 72.2%. No association existed between HR‐HPV and patient's demographics, dietary habit and other predisposing factors.
Conclusion
The place of HR‐HPV as a possible aetiological factor for HNSCC has further been established from this study. |
| doi_str_mv | 10.1111/odi.12110 |
| format | Article |
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To analyse the association between high‐risk human papillomavirus (HR‐HPV) and other risk factors in the aetiology of head and neck squamous cell carcinoma (HNSCC) in an Asian population.
Study Design
This study is a cross‐sectional analysis of 80 patients who were diagnosed with HNSCC. Patients' demographics, dietary habit, medical and social history were obtained. Surgical specimens from these patients were then histologically analysed using H&E stain and immunohistochemistry (IHC) for the presence of HR‐HPV primary antibody.
Results
High‐risk human papillomavirus was detected in 41 patients, representing 51.3% of the 80 paraffin‐embedded tissues of HNSCC; 27.5% of these were weak positive, 10.0% medium positive and 13.8% were strongly positive for the HR‐HPV on IHC. The tongue lesions had the highest HR‐HPV infection of 72.2%. No association existed between HR‐HPV and patient's demographics, dietary habit and other predisposing factors.
Conclusion
The place of HR‐HPV as a possible aetiological factor for HNSCC has further been established from this study.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.12110</identifier><identifier>PMID: 23590799</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Asian Continental Ancestry Group ; Carcinoma, Squamous Cell - virology ; Cross-Sectional Studies ; Dentistry ; Female ; Head & neck cancer ; Head and Neck Neoplasms - virology ; head and neck squamous cell carcinoma ; high-risk human papillomavirus ; Human papillomavirus ; Humans ; immunohistochemistry ; Male ; Middle Aged ; Papillomavirus Infections - complications ; Risk Factors ; Squamous Cell Carcinoma of Head and Neck ; Young Adult</subject><ispartof>Oral diseases, 2014-04, Vol.20 (3), p.288-293</ispartof><rights>2013 John Wiley & Sons A/S</rights><rights>2013 John Wiley & Sons A/S.</rights><rights>Copyright © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3910-5a3cbb09f521104d916f84a13e771329c82c592c9964d3efd2179d4593e3e0bc3</citedby><cites>FETCH-LOGICAL-c3910-5a3cbb09f521104d916f84a13e771329c82c592c9964d3efd2179d4593e3e0bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.12110$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.12110$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23590799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iqbal, A</creatorcontrib><creatorcontrib>Warraich, R</creatorcontrib><creatorcontrib>Udeabor, SE</creatorcontrib><creatorcontrib>Rana, M</creatorcontrib><creatorcontrib>Eckardt, AM</creatorcontrib><creatorcontrib>Gellrich, N-C</creatorcontrib><creatorcontrib>Rana, M</creatorcontrib><title>Role of human papillomavirus infection and other factors in patients with head and neck squamous cell carcinoma</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
To analyse the association between high‐risk human papillomavirus (HR‐HPV) and other risk factors in the aetiology of head and neck squamous cell carcinoma (HNSCC) in an Asian population.
Study Design
This study is a cross‐sectional analysis of 80 patients who were diagnosed with HNSCC. Patients' demographics, dietary habit, medical and social history were obtained. Surgical specimens from these patients were then histologically analysed using H&E stain and immunohistochemistry (IHC) for the presence of HR‐HPV primary antibody.
Results
High‐risk human papillomavirus was detected in 41 patients, representing 51.3% of the 80 paraffin‐embedded tissues of HNSCC; 27.5% of these were weak positive, 10.0% medium positive and 13.8% were strongly positive for the HR‐HPV on IHC. The tongue lesions had the highest HR‐HPV infection of 72.2%. No association existed between HR‐HPV and patient's demographics, dietary habit and other predisposing factors.
Conclusion
The place of HR‐HPV as a possible aetiological factor for HNSCC has further been established from this study.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Cross-Sectional Studies</subject><subject>Dentistry</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms - virology</subject><subject>head and neck squamous cell carcinoma</subject><subject>high-risk human papillomavirus</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Papillomavirus Infections - complications</subject><subject>Risk Factors</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Young Adult</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P5SAUhokZo4668A8YktnoospHactSvY6aGI1fcTIbwqWnuWgLV2jH8d9LverCRBZAwnOevIeD0BYlezStfV_bPcooJUtojRaEZqRi4ke6c5FngvE_q-hnjA-E0FJytoJWGReSlFKuIX_tW8C-wbOh0w7P9dy2re_0PxuGiK1rwPTWO6xdjX0_g4AbbXofxrdE9xZcH_Gz7Wd4Brp-4xyYRxyfBt355DDQttjoYKxL3g203Og2wub7uY7ufh_fHp1m55cnZ0cH55nhkpJMaG6mUyIbMbaV15IWTZVryqEsKWfSVMwIyYyURV5zaGqWWqtzITlwIFPD19HOwjsP_mmA2KvOxjGKdpBSKSpIlbNxS-ivL-iDH4JL6UaqzIuy4kWidheUCT7GAI2aB9vp8KIoUeMUVJqCeptCYrffjcO0g_qT_Pj2BOwvgGfbwsv3JnU5OftQZosKG3v4_1mhw6MqSl4KdX9xoiZXhzc3xeFfNeGv-g-f8g</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Iqbal, A</creator><creator>Warraich, R</creator><creator>Udeabor, SE</creator><creator>Rana, M</creator><creator>Eckardt, AM</creator><creator>Gellrich, N-C</creator><creator>Rana, M</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Role of human papillomavirus infection and other factors in patients with head and neck squamous cell carcinoma</title><author>Iqbal, A ; Warraich, R ; Udeabor, SE ; Rana, M ; Eckardt, AM ; Gellrich, N-C ; Rana, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3910-5a3cbb09f521104d916f84a13e771329c82c592c9964d3efd2179d4593e3e0bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Cross-Sectional Studies</topic><topic>Dentistry</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms - virology</topic><topic>head and neck squamous cell carcinoma</topic><topic>high-risk human papillomavirus</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Papillomavirus Infections - complications</topic><topic>Risk Factors</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iqbal, A</creatorcontrib><creatorcontrib>Warraich, R</creatorcontrib><creatorcontrib>Udeabor, SE</creatorcontrib><creatorcontrib>Rana, M</creatorcontrib><creatorcontrib>Eckardt, AM</creatorcontrib><creatorcontrib>Gellrich, N-C</creatorcontrib><creatorcontrib>Rana, M</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iqbal, A</au><au>Warraich, R</au><au>Udeabor, SE</au><au>Rana, M</au><au>Eckardt, AM</au><au>Gellrich, N-C</au><au>Rana, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of human papillomavirus infection and other factors in patients with head and neck squamous cell carcinoma</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2014-04</date><risdate>2014</risdate><volume>20</volume><issue>3</issue><spage>288</spage><epage>293</epage><pages>288-293</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objective
To analyse the association between high‐risk human papillomavirus (HR‐HPV) and other risk factors in the aetiology of head and neck squamous cell carcinoma (HNSCC) in an Asian population.
Study Design
This study is a cross‐sectional analysis of 80 patients who were diagnosed with HNSCC. Patients' demographics, dietary habit, medical and social history were obtained. Surgical specimens from these patients were then histologically analysed using H&E stain and immunohistochemistry (IHC) for the presence of HR‐HPV primary antibody.
Results
High‐risk human papillomavirus was detected in 41 patients, representing 51.3% of the 80 paraffin‐embedded tissues of HNSCC; 27.5% of these were weak positive, 10.0% medium positive and 13.8% were strongly positive for the HR‐HPV on IHC. The tongue lesions had the highest HR‐HPV infection of 72.2%. No association existed between HR‐HPV and patient's demographics, dietary habit and other predisposing factors.
Conclusion
The place of HR‐HPV as a possible aetiological factor for HNSCC has further been established from this study.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>23590799</pmid><doi>10.1111/odi.12110</doi><tpages>6</tpages></addata></record> |
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| ispartof | Oral diseases, 2014-04, Vol.20 (3), p.288-293 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | Adolescent Adult Aged Asian Continental Ancestry Group Carcinoma, Squamous Cell - virology Cross-Sectional Studies Dentistry Female Head & neck cancer Head and Neck Neoplasms - virology head and neck squamous cell carcinoma high-risk human papillomavirus Human papillomavirus Humans immunohistochemistry Male Middle Aged Papillomavirus Infections - complications Risk Factors Squamous Cell Carcinoma of Head and Neck Young Adult |
| title | Role of human papillomavirus infection and other factors in patients with head and neck squamous cell carcinoma |
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