Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth
Objective This study investigates the expression of transcription factor nuclear factor‐kappa B (NF‐κB) and its relation to various cellular mediators that act in the pathogenesis of phenytoin‐induced gingival overgrowth. Materials and methods Eighteen epileptic patients had phenytoin‐induced gingiv...
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| Veröffentlicht in: | Oral diseases 2014-04, Vol.20 (3), p.294-300 |
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| creator | Arabaci, T Köse, O Kizildağ, A Albayrak, M Çiçek, Y Kara, A |
| description | Objective
This study investigates the expression of transcription factor nuclear factor‐kappa B (NF‐κB) and its relation to various cellular mediators that act in the pathogenesis of phenytoin‐induced gingival overgrowth.
Materials and methods
Eighteen epileptic patients had phenytoin‐induced gingival overgrowth (PHT‐GO), 20 patients with plaque‐induced gingivitis (Gingivitis), and 20 periodontally and systemically healthy individuals (Control) were included in this study. The expression of activated NF‐κB subunits (p50 and p65), IL‐1β, TNF‐α and TGFβ‐1 levels were examined in the gingival sections obtained from each participant.
Results
The results demonstrated a significantly higher expression of p65 in fibroblasts in PHT‐GO group with respect to Gingivitis (P |
| doi_str_mv | 10.1111/odi.12111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1508425045</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1508425045</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4571-bd7d509f8fbe9a63391cd41d58567bea76f26425087b6a4547aafbb8f850c3d33</originalsourceid><addsrcrecordid>eNp1kF9LwzAUxYMo_pk--AWk4Is-VJOmSdpHp24OREWUiS8hbZIZ7ZqatNN9ezM3fRC8cLn34XcOhwPAPoInKMypleYEJeFbA9uIQhTDLCHr4cckjUmCn7bAjvevECKW42QTbCWYEhR2GwzvbaUiq6O6KyslXKRF2VoXvYmmEXE_MnXUvKh63lpTx6aWXalkNDH1xMxEFdmZchNnP9qXXbChReXV3ur2wOPg8uH8Kr6-HY7Oz67jMiUMxYVkksBcZ7pQuaAY56iUKZIkI5QVSjCqE5omBGasoCIlKRNCF0WmMwJLLDHugaOlb-Pse6d8y6fGl6qqRK1s5zkK0oU-JQE9_IO-2s7VId2CYillOMsDdbykSme9d0rzxpmpcHOOIF-0y0O7_LvdwB6sHLtiquQv-VNnAE6XwIep1Px_J357MfqxjJcK41v1-asQ7o2HfIzw8c2Q9-nN3fN4kHGKvwASGJFz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1507467389</pqid></control><display><type>article</type><title>Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Arabaci, T ; Köse, O ; Kizildağ, A ; Albayrak, M ; Çiçek, Y ; Kara, A</creator><creatorcontrib>Arabaci, T ; Köse, O ; Kizildağ, A ; Albayrak, M ; Çiçek, Y ; Kara, A</creatorcontrib><description>Objective
This study investigates the expression of transcription factor nuclear factor‐kappa B (NF‐κB) and its relation to various cellular mediators that act in the pathogenesis of phenytoin‐induced gingival overgrowth.
Materials and methods
Eighteen epileptic patients had phenytoin‐induced gingival overgrowth (PHT‐GO), 20 patients with plaque‐induced gingivitis (Gingivitis), and 20 periodontally and systemically healthy individuals (Control) were included in this study. The expression of activated NF‐κB subunits (p50 and p65), IL‐1β, TNF‐α and TGFβ‐1 levels were examined in the gingival sections obtained from each participant.
Results
The results demonstrated a significantly higher expression of p65 in fibroblasts in PHT‐GO group with respect to Gingivitis (P < 0.05) and control groups (P < 0.01). However, we found no statistically significant differences between PHT‐GO and Gingivitis groups according to the immunohistochemical staining in macrophages (P > 0.05). Immune‐reactive TGFβ‐1 levels in the gingival connective tissue cells were statistically higher in PHT‐GO group with respect to Gingivitis group(P < 0.05). Statistically significant correlations were found between the HI and activated TGFβ‐1 and p65 levels in PHT‐GO group.
Conclusion
The results of this study showed that NF‐κB is activated in PHT‐related gingival overgrowth. This study may provide a basis for future research into specific NF‐κB inhibition for preventing of the side effects of this drug.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.12111</identifier><identifier>PMID: 23651365</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Anticonvulsants - adverse effects ; Dentistry ; Female ; gingival overgrowth ; Gingival Overgrowth - chemically induced ; Gingivitis - chemically induced ; growth factors ; Gum disease ; Humans ; Male ; NF-kappa B - immunology ; NF-kappa B - physiology ; nuclear factor kappa-B ; Pharmacology ; phenytoin ; Phenytoin - adverse effects ; Side effects ; Young Adult</subject><ispartof>Oral diseases, 2014-04, Vol.20 (3), p.294-300</ispartof><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4571-bd7d509f8fbe9a63391cd41d58567bea76f26425087b6a4547aafbb8f850c3d33</citedby><cites>FETCH-LOGICAL-c4571-bd7d509f8fbe9a63391cd41d58567bea76f26425087b6a4547aafbb8f850c3d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.12111$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.12111$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23651365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arabaci, T</creatorcontrib><creatorcontrib>Köse, O</creatorcontrib><creatorcontrib>Kizildağ, A</creatorcontrib><creatorcontrib>Albayrak, M</creatorcontrib><creatorcontrib>Çiçek, Y</creatorcontrib><creatorcontrib>Kara, A</creatorcontrib><title>Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objective
This study investigates the expression of transcription factor nuclear factor‐kappa B (NF‐κB) and its relation to various cellular mediators that act in the pathogenesis of phenytoin‐induced gingival overgrowth.
Materials and methods
Eighteen epileptic patients had phenytoin‐induced gingival overgrowth (PHT‐GO), 20 patients with plaque‐induced gingivitis (Gingivitis), and 20 periodontally and systemically healthy individuals (Control) were included in this study. The expression of activated NF‐κB subunits (p50 and p65), IL‐1β, TNF‐α and TGFβ‐1 levels were examined in the gingival sections obtained from each participant.
Results
The results demonstrated a significantly higher expression of p65 in fibroblasts in PHT‐GO group with respect to Gingivitis (P < 0.05) and control groups (P < 0.01). However, we found no statistically significant differences between PHT‐GO and Gingivitis groups according to the immunohistochemical staining in macrophages (P > 0.05). Immune‐reactive TGFβ‐1 levels in the gingival connective tissue cells were statistically higher in PHT‐GO group with respect to Gingivitis group(P < 0.05). Statistically significant correlations were found between the HI and activated TGFβ‐1 and p65 levels in PHT‐GO group.
Conclusion
The results of this study showed that NF‐κB is activated in PHT‐related gingival overgrowth. This study may provide a basis for future research into specific NF‐κB inhibition for preventing of the side effects of this drug.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anticonvulsants - adverse effects</subject><subject>Dentistry</subject><subject>Female</subject><subject>gingival overgrowth</subject><subject>Gingival Overgrowth - chemically induced</subject><subject>Gingivitis - chemically induced</subject><subject>growth factors</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Male</subject><subject>NF-kappa B - immunology</subject><subject>NF-kappa B - physiology</subject><subject>nuclear factor kappa-B</subject><subject>Pharmacology</subject><subject>phenytoin</subject><subject>Phenytoin - adverse effects</subject><subject>Side effects</subject><subject>Young Adult</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF9LwzAUxYMo_pk--AWk4Is-VJOmSdpHp24OREWUiS8hbZIZ7ZqatNN9ezM3fRC8cLn34XcOhwPAPoInKMypleYEJeFbA9uIQhTDLCHr4cckjUmCn7bAjvevECKW42QTbCWYEhR2GwzvbaUiq6O6KyslXKRF2VoXvYmmEXE_MnXUvKh63lpTx6aWXalkNDH1xMxEFdmZchNnP9qXXbChReXV3ur2wOPg8uH8Kr6-HY7Oz67jMiUMxYVkksBcZ7pQuaAY56iUKZIkI5QVSjCqE5omBGasoCIlKRNCF0WmMwJLLDHugaOlb-Pse6d8y6fGl6qqRK1s5zkK0oU-JQE9_IO-2s7VId2CYillOMsDdbykSme9d0rzxpmpcHOOIF-0y0O7_LvdwB6sHLtiquQv-VNnAE6XwIep1Px_J357MfqxjJcK41v1-asQ7o2HfIzw8c2Q9-nN3fN4kHGKvwASGJFz</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Arabaci, T</creator><creator>Köse, O</creator><creator>Kizildağ, A</creator><creator>Albayrak, M</creator><creator>Çiçek, Y</creator><creator>Kara, A</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth</title><author>Arabaci, T ; Köse, O ; Kizildağ, A ; Albayrak, M ; Çiçek, Y ; Kara, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4571-bd7d509f8fbe9a63391cd41d58567bea76f26425087b6a4547aafbb8f850c3d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anticonvulsants - adverse effects</topic><topic>Dentistry</topic><topic>Female</topic><topic>gingival overgrowth</topic><topic>Gingival Overgrowth - chemically induced</topic><topic>Gingivitis - chemically induced</topic><topic>growth factors</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Male</topic><topic>NF-kappa B - immunology</topic><topic>NF-kappa B - physiology</topic><topic>nuclear factor kappa-B</topic><topic>Pharmacology</topic><topic>phenytoin</topic><topic>Phenytoin - adverse effects</topic><topic>Side effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arabaci, T</creatorcontrib><creatorcontrib>Köse, O</creatorcontrib><creatorcontrib>Kizildağ, A</creatorcontrib><creatorcontrib>Albayrak, M</creatorcontrib><creatorcontrib>Çiçek, Y</creatorcontrib><creatorcontrib>Kara, A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arabaci, T</au><au>Köse, O</au><au>Kizildağ, A</au><au>Albayrak, M</au><au>Çiçek, Y</au><au>Kara, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2014-04</date><risdate>2014</risdate><volume>20</volume><issue>3</issue><spage>294</spage><epage>300</epage><pages>294-300</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objective
This study investigates the expression of transcription factor nuclear factor‐kappa B (NF‐κB) and its relation to various cellular mediators that act in the pathogenesis of phenytoin‐induced gingival overgrowth.
Materials and methods
Eighteen epileptic patients had phenytoin‐induced gingival overgrowth (PHT‐GO), 20 patients with plaque‐induced gingivitis (Gingivitis), and 20 periodontally and systemically healthy individuals (Control) were included in this study. The expression of activated NF‐κB subunits (p50 and p65), IL‐1β, TNF‐α and TGFβ‐1 levels were examined in the gingival sections obtained from each participant.
Results
The results demonstrated a significantly higher expression of p65 in fibroblasts in PHT‐GO group with respect to Gingivitis (P < 0.05) and control groups (P < 0.01). However, we found no statistically significant differences between PHT‐GO and Gingivitis groups according to the immunohistochemical staining in macrophages (P > 0.05). Immune‐reactive TGFβ‐1 levels in the gingival connective tissue cells were statistically higher in PHT‐GO group with respect to Gingivitis group(P < 0.05). Statistically significant correlations were found between the HI and activated TGFβ‐1 and p65 levels in PHT‐GO group.
Conclusion
The results of this study showed that NF‐κB is activated in PHT‐related gingival overgrowth. This study may provide a basis for future research into specific NF‐κB inhibition for preventing of the side effects of this drug.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>23651365</pmid><doi>10.1111/odi.12111</doi><tpages>7</tpages></addata></record> |
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| ispartof | Oral diseases, 2014-04, Vol.20 (3), p.294-300 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Anticonvulsants - adverse effects Dentistry Female gingival overgrowth Gingival Overgrowth - chemically induced Gingivitis - chemically induced growth factors Gum disease Humans Male NF-kappa B - immunology NF-kappa B - physiology nuclear factor kappa-B Pharmacology phenytoin Phenytoin - adverse effects Side effects Young Adult |
| title | Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth |
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