Autologous muscle-derived cells for the treatment of female stress urinary incontinence: A 2-year follow-up of a polish investigation
Aims We evaluated the safety, feasibility and initial effects of therapy with muscle‐derived cells (MDCs) for women with stress urinary incontinence (SUI). Methods MDCs were isolated from an upper‐arm muscle biopsy from 16 women with SUI. Cells were isolated by enzymatic digestion and expanded in vi...
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| Veröffentlicht in: | Neurourology and urodynamics 2014-03, Vol.33 (3), p.324-330 |
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| creator | Stangel-Wojcikiewicz, Klaudia Jarocha, Danuta Piwowar, Monika Jach, Robert Uhl, Tadeusz Basta, Antoni Majka, Marcin |
| description | Aims
We evaluated the safety, feasibility and initial effects of therapy with muscle‐derived cells (MDCs) for women with stress urinary incontinence (SUI).
Methods
MDCs were isolated from an upper‐arm muscle biopsy from 16 women with SUI. Cells were isolated by enzymatic digestion and expanded in vitro for 8–10 weeks. A quantity of 0.6–25 × 106 of the obtained cells were injected transurethrally into the urethral rhabdosphincter of women under local anesthesia. The cells were placed circumferentially at the 9, 12, and 3 O'clock positions with endoscopic guidance.
Results
The initial results of the treatment of SUI with adult muscle‐derived stem cells demonstrate the safety and feasibility of using these cells. The 2‐year follow‐up revealed a 75% success rate, with some patients achieving complete improvement (50%) and some patients achieving partial improvement (25%), suggesting that the prospects for this method are encouraging.
Conclusions
Stem cell therapy promises to become a minimally invasive method for the regeneration of the urethral rhabdosphincter muscle. Injecting a small number of cells does not preclude obtaining the desired therapeutic result. Neurourol. Urodynam. 33:324–330, 2014. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/nau.22404 |
| format | Article |
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We evaluated the safety, feasibility and initial effects of therapy with muscle‐derived cells (MDCs) for women with stress urinary incontinence (SUI).
Methods
MDCs were isolated from an upper‐arm muscle biopsy from 16 women with SUI. Cells were isolated by enzymatic digestion and expanded in vitro for 8–10 weeks. A quantity of 0.6–25 × 106 of the obtained cells were injected transurethrally into the urethral rhabdosphincter of women under local anesthesia. The cells were placed circumferentially at the 9, 12, and 3 O'clock positions with endoscopic guidance.
Results
The initial results of the treatment of SUI with adult muscle‐derived stem cells demonstrate the safety and feasibility of using these cells. The 2‐year follow‐up revealed a 75% success rate, with some patients achieving complete improvement (50%) and some patients achieving partial improvement (25%), suggesting that the prospects for this method are encouraging.
Conclusions
Stem cell therapy promises to become a minimally invasive method for the regeneration of the urethral rhabdosphincter muscle. Injecting a small number of cells does not preclude obtaining the desired therapeutic result. Neurourol. Urodynam. 33:324–330, 2014. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0733-2467</identifier><identifier>EISSN: 1520-6777</identifier><identifier>DOI: 10.1002/nau.22404</identifier><identifier>PMID: 23606303</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Autografts ; Cells, Cultured ; Endoscopy ; Feasibility Studies ; Female ; Humans ; Middle Aged ; Muscle, Skeletal - cytology ; Muscle, Skeletal - transplantation ; muscle-derived cells ; Poland ; Recovery of Function ; Regeneration ; Stem Cell Transplantation - adverse effects ; Stem Cell Transplantation - methods ; stress urinary incontinence ; therapy ; Time Factors ; Treatment Outcome ; Upper Extremity ; Urethra - physiopathology ; Urinary Bladder - physiopathology ; Urinary Incontinence, Stress - diagnosis ; Urinary Incontinence, Stress - physiopathology ; Urinary Incontinence, Stress - therapy ; Urodynamics</subject><ispartof>Neurourology and urodynamics, 2014-03, Vol.33 (3), p.324-330</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4574-21383ca8521608d9a838111aba02006a7f3b25ff3407704e66f999a04eb5de1b3</citedby><cites>FETCH-LOGICAL-c4574-21383ca8521608d9a838111aba02006a7f3b25ff3407704e66f999a04eb5de1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fnau.22404$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fnau.22404$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23606303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stangel-Wojcikiewicz, Klaudia</creatorcontrib><creatorcontrib>Jarocha, Danuta</creatorcontrib><creatorcontrib>Piwowar, Monika</creatorcontrib><creatorcontrib>Jach, Robert</creatorcontrib><creatorcontrib>Uhl, Tadeusz</creatorcontrib><creatorcontrib>Basta, Antoni</creatorcontrib><creatorcontrib>Majka, Marcin</creatorcontrib><title>Autologous muscle-derived cells for the treatment of female stress urinary incontinence: A 2-year follow-up of a polish investigation</title><title>Neurourology and urodynamics</title><addtitle>Neurourol. Urodynam</addtitle><description>Aims
We evaluated the safety, feasibility and initial effects of therapy with muscle‐derived cells (MDCs) for women with stress urinary incontinence (SUI).
Methods
MDCs were isolated from an upper‐arm muscle biopsy from 16 women with SUI. Cells were isolated by enzymatic digestion and expanded in vitro for 8–10 weeks. A quantity of 0.6–25 × 106 of the obtained cells were injected transurethrally into the urethral rhabdosphincter of women under local anesthesia. The cells were placed circumferentially at the 9, 12, and 3 O'clock positions with endoscopic guidance.
Results
The initial results of the treatment of SUI with adult muscle‐derived stem cells demonstrate the safety and feasibility of using these cells. The 2‐year follow‐up revealed a 75% success rate, with some patients achieving complete improvement (50%) and some patients achieving partial improvement (25%), suggesting that the prospects for this method are encouraging.
Conclusions
Stem cell therapy promises to become a minimally invasive method for the regeneration of the urethral rhabdosphincter muscle. Injecting a small number of cells does not preclude obtaining the desired therapeutic result. Neurourol. Urodynam. 33:324–330, 2014. © 2013 Wiley Periodicals, Inc.</description><subject>Autografts</subject><subject>Cells, Cultured</subject><subject>Endoscopy</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - transplantation</subject><subject>muscle-derived cells</subject><subject>Poland</subject><subject>Recovery of Function</subject><subject>Regeneration</subject><subject>Stem Cell Transplantation - adverse effects</subject><subject>Stem Cell Transplantation - methods</subject><subject>stress urinary incontinence</subject><subject>therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Upper Extremity</subject><subject>Urethra - physiopathology</subject><subject>Urinary Bladder - physiopathology</subject><subject>Urinary Incontinence, Stress - diagnosis</subject><subject>Urinary Incontinence, Stress - physiopathology</subject><subject>Urinary Incontinence, Stress - therapy</subject><subject>Urodynamics</subject><issn>0733-2467</issn><issn>1520-6777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS0EosPAghdAltjAIq3_nbAbVXRAlGFD1aXlJDeti2MPdtIyD8B742HaLpBY-cr6zrn2OQi9puSYEsJOgp2PGRNEPEELKhmplNb6KVoQzXnFhNJH6EXON4SQmovmOTpiXBHFCV-g36t5ij5exTnjcc6dh6qH5G6hxx14n_EQE56uAU8J7DRCmHAc8ACj9YBzucwZz8kFm3bYhS6GyQUIHXzAK8yqHdhUHLyPd9W83Sst3kbv8nWBbyFP7spOLoaX6NlgfYZX9-cSXZx9_H76qTr_tv58ujqvOiG1qBjlNe9sLRlVpO4bW_OaUmpbSxghyuqBt0wOAxdEayJAqaFpGlumVvZAW75E7w6-2xR_zmW_GV3e_9MGKAkYKkktmKhLNEv09h_0Js4plNftKS2FVIoX6v2B6lLMOcFgtsmNJQxDidl3Y0o35m83hX1z7zi3I_SP5EMZBTg5AHfOw-7_TmazuniwrA4Klyf49aiw6YdRmmtpLjdrc3a5aeSafzFf-R8JTKem</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Stangel-Wojcikiewicz, Klaudia</creator><creator>Jarocha, Danuta</creator><creator>Piwowar, Monika</creator><creator>Jach, Robert</creator><creator>Uhl, Tadeusz</creator><creator>Basta, Antoni</creator><creator>Majka, Marcin</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Autologous muscle-derived cells for the treatment of female stress urinary incontinence: A 2-year follow-up of a polish investigation</title><author>Stangel-Wojcikiewicz, Klaudia ; Jarocha, Danuta ; Piwowar, Monika ; Jach, Robert ; Uhl, Tadeusz ; Basta, Antoni ; Majka, Marcin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4574-21383ca8521608d9a838111aba02006a7f3b25ff3407704e66f999a04eb5de1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Autografts</topic><topic>Cells, Cultured</topic><topic>Endoscopy</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - transplantation</topic><topic>muscle-derived cells</topic><topic>Poland</topic><topic>Recovery of Function</topic><topic>Regeneration</topic><topic>Stem Cell Transplantation - adverse effects</topic><topic>Stem Cell Transplantation - methods</topic><topic>stress urinary incontinence</topic><topic>therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Upper Extremity</topic><topic>Urethra - physiopathology</topic><topic>Urinary Bladder - physiopathology</topic><topic>Urinary Incontinence, Stress - diagnosis</topic><topic>Urinary Incontinence, Stress - physiopathology</topic><topic>Urinary Incontinence, Stress - therapy</topic><topic>Urodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stangel-Wojcikiewicz, Klaudia</creatorcontrib><creatorcontrib>Jarocha, Danuta</creatorcontrib><creatorcontrib>Piwowar, Monika</creatorcontrib><creatorcontrib>Jach, Robert</creatorcontrib><creatorcontrib>Uhl, Tadeusz</creatorcontrib><creatorcontrib>Basta, Antoni</creatorcontrib><creatorcontrib>Majka, Marcin</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurourology and urodynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stangel-Wojcikiewicz, Klaudia</au><au>Jarocha, Danuta</au><au>Piwowar, Monika</au><au>Jach, Robert</au><au>Uhl, Tadeusz</au><au>Basta, Antoni</au><au>Majka, Marcin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autologous muscle-derived cells for the treatment of female stress urinary incontinence: A 2-year follow-up of a polish investigation</atitle><jtitle>Neurourology and urodynamics</jtitle><addtitle>Neurourol. Urodynam</addtitle><date>2014-03</date><risdate>2014</risdate><volume>33</volume><issue>3</issue><spage>324</spage><epage>330</epage><pages>324-330</pages><issn>0733-2467</issn><eissn>1520-6777</eissn><abstract>Aims
We evaluated the safety, feasibility and initial effects of therapy with muscle‐derived cells (MDCs) for women with stress urinary incontinence (SUI).
Methods
MDCs were isolated from an upper‐arm muscle biopsy from 16 women with SUI. Cells were isolated by enzymatic digestion and expanded in vitro for 8–10 weeks. A quantity of 0.6–25 × 106 of the obtained cells were injected transurethrally into the urethral rhabdosphincter of women under local anesthesia. The cells were placed circumferentially at the 9, 12, and 3 O'clock positions with endoscopic guidance.
Results
The initial results of the treatment of SUI with adult muscle‐derived stem cells demonstrate the safety and feasibility of using these cells. The 2‐year follow‐up revealed a 75% success rate, with some patients achieving complete improvement (50%) and some patients achieving partial improvement (25%), suggesting that the prospects for this method are encouraging.
Conclusions
Stem cell therapy promises to become a minimally invasive method for the regeneration of the urethral rhabdosphincter muscle. Injecting a small number of cells does not preclude obtaining the desired therapeutic result. Neurourol. Urodynam. 33:324–330, 2014. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23606303</pmid><doi>10.1002/nau.22404</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neurourology and urodynamics, 2014-03, Vol.33 (3), p.324-330 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Autografts Cells, Cultured Endoscopy Feasibility Studies Female Humans Middle Aged Muscle, Skeletal - cytology Muscle, Skeletal - transplantation muscle-derived cells Poland Recovery of Function Regeneration Stem Cell Transplantation - adverse effects Stem Cell Transplantation - methods stress urinary incontinence therapy Time Factors Treatment Outcome Upper Extremity Urethra - physiopathology Urinary Bladder - physiopathology Urinary Incontinence, Stress - diagnosis Urinary Incontinence, Stress - physiopathology Urinary Incontinence, Stress - therapy Urodynamics |
| title | Autologous muscle-derived cells for the treatment of female stress urinary incontinence: A 2-year follow-up of a polish investigation |
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