Increased Risk for Respiratory Syncytial Virus-associated, Community-acquired Alveolar Pneumonia in Infants Born at 31–36 Weeks of Gestation
BACKGROUND:We compared hospitalization and pediatric intensive care unit (PICU) admission rates for community-acquired alveolar pneumonia (CAAP) and respiratory syncytial virus (RSV)-associated CAAP (RSV-CAAP) in non-RSV–immunized children 36 weeks GA). METHODS:Nasopharyngeal samples for RSV were ob...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2014-04, Vol.33 (4), p.381-386 |
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| creator | Greenberg, David Dagan, Ron Shany, Eilon Bar-Ziv, Jacob Givon-Lavi, Noga |
| description | BACKGROUND:We compared hospitalization and pediatric intensive care unit (PICU) admission rates for community-acquired alveolar pneumonia (CAAP) and respiratory syncytial virus (RSV)-associated CAAP (RSV-CAAP) in non-RSV–immunized children 36 weeks GA).
METHODS:Nasopharyngeal samples for RSV were obtained prospectively (2004–2011) during RSV season, from hospitalized children with radiographic-diagnosed CAAP. Soroka University Medical Center is the only hospital in the region, enabling population-based rate calculation. Relative risks (RR) and 95% confidence intervals (95% CI) were calculated comparing RSV-CAAP incidence in 31–36 weeks GA with >36 weeks GA children.
RESULTS:CAAP hospitalization incidences (per 1000 population) were 23.6 and 9.4 (RR2.52; 95% CI2.13–2.68), respectively; the respective incidences of PICU admission for overall CAAP were 1.8 and 0.2 (RR7.88; 95% CI4.59–11.83). The RRs (and 95% CI) for RSV-CAAP hospitalizations and PICU admission rates were (after extrapolation) 15.2 and 5.8 (RR2.79; 95% CI2.31–3.06) and 1.1 and 0.1 (RR9.14; 95% CI4.93–16.96), respectively. In a multiregression analysis in patients with RSV-CAAP versus CAAP, 31–36 weeks GA was an independent risk factor for hospitalization (RR1.485; 95% CI1.03–2.14).
CONCLUSIONS:Children 36 weeks GA. Moreover, in late premature children, RSV represented a 50% increased risk for CAAP compared with infants born at term. |
| doi_str_mv | 10.1097/INF.0000000000000130 |
| format | Article |
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METHODS:Nasopharyngeal samples for RSV were obtained prospectively (2004–2011) during RSV season, from hospitalized children with radiographic-diagnosed CAAP. Soroka University Medical Center is the only hospital in the region, enabling population-based rate calculation. Relative risks (RR) and 95% confidence intervals (95% CI) were calculated comparing RSV-CAAP incidence in 31–36 weeks GA with >36 weeks GA children.
RESULTS:CAAP hospitalization incidences (per 1000 population) were 23.6 and 9.4 (RR2.52; 95% CI2.13–2.68), respectively; the respective incidences of PICU admission for overall CAAP were 1.8 and 0.2 (RR7.88; 95% CI4.59–11.83). The RRs (and 95% CI) for RSV-CAAP hospitalizations and PICU admission rates were (after extrapolation) 15.2 and 5.8 (RR2.79; 95% CI2.31–3.06) and 1.1 and 0.1 (RR9.14; 95% CI4.93–16.96), respectively. In a multiregression analysis in patients with RSV-CAAP versus CAAP, 31–36 weeks GA was an independent risk factor for hospitalization (RR1.485; 95% CI1.03–2.14).
CONCLUSIONS:Children <24-month-old born at 31–36 weeks GA are at increased risk for hospitalization and PICU admission for both overall CAAP and RSV-associated CAAP compared with those born at >36 weeks GA. Moreover, in late premature children, RSV represented a 50% increased risk for CAAP compared with infants born at term.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/INF.0000000000000130</identifier><identifier>PMID: 24145171</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Hagerstown, MD: by Lippincott Williams & Wilkins, Inc</publisher><subject>Arabs - statistics & numerical data ; Biological and medical sciences ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - ethnology ; Diseases of mother, fetus and pregnancy ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Hospitalization ; Human viral diseases ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases - epidemiology ; Infant, Newborn, Diseases - ethnology ; Infant, Premature ; Infectious diseases ; Israel - epidemiology ; Jews - statistics & numerical data ; Male ; Medical sciences ; Pneumology ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - ethnology ; Pregnancy. Fetus. Placenta ; Prospective Studies ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - ethnology ; Respiratory system : syndromes and miscellaneous diseases ; Risk Factors ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases</subject><ispartof>The Pediatric infectious disease journal, 2014-04, Vol.33 (4), p.381-386</ispartof><rights>2014 by Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3860-122de3c6393ca5a3adc36d039697924e0631adf48bb125adb6e3236ac05b4ab93</citedby><cites>FETCH-LOGICAL-c3860-122de3c6393ca5a3adc36d039697924e0631adf48bb125adb6e3236ac05b4ab93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28403463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24145171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greenberg, David</creatorcontrib><creatorcontrib>Dagan, Ron</creatorcontrib><creatorcontrib>Shany, Eilon</creatorcontrib><creatorcontrib>Bar-Ziv, Jacob</creatorcontrib><creatorcontrib>Givon-Lavi, Noga</creatorcontrib><title>Increased Risk for Respiratory Syncytial Virus-associated, Community-acquired Alveolar Pneumonia in Infants Born at 31–36 Weeks of Gestation</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND:We compared hospitalization and pediatric intensive care unit (PICU) admission rates for community-acquired alveolar pneumonia (CAAP) and respiratory syncytial virus (RSV)-associated CAAP (RSV-CAAP) in non-RSV–immunized children <24-month-old born at 31–36 weeks gestational age (GA) versus those born at term (>36 weeks GA).
METHODS:Nasopharyngeal samples for RSV were obtained prospectively (2004–2011) during RSV season, from hospitalized children with radiographic-diagnosed CAAP. Soroka University Medical Center is the only hospital in the region, enabling population-based rate calculation. Relative risks (RR) and 95% confidence intervals (95% CI) were calculated comparing RSV-CAAP incidence in 31–36 weeks GA with >36 weeks GA children.
RESULTS:CAAP hospitalization incidences (per 1000 population) were 23.6 and 9.4 (RR2.52; 95% CI2.13–2.68), respectively; the respective incidences of PICU admission for overall CAAP were 1.8 and 0.2 (RR7.88; 95% CI4.59–11.83). The RRs (and 95% CI) for RSV-CAAP hospitalizations and PICU admission rates were (after extrapolation) 15.2 and 5.8 (RR2.79; 95% CI2.31–3.06) and 1.1 and 0.1 (RR9.14; 95% CI4.93–16.96), respectively. In a multiregression analysis in patients with RSV-CAAP versus CAAP, 31–36 weeks GA was an independent risk factor for hospitalization (RR1.485; 95% CI1.03–2.14).
CONCLUSIONS:Children <24-month-old born at 31–36 weeks GA are at increased risk for hospitalization and PICU admission for both overall CAAP and RSV-associated CAAP compared with those born at >36 weeks GA. Moreover, in late premature children, RSV represented a 50% increased risk for CAAP compared with infants born at term.</description><subject>Arabs - statistics & numerical data</subject><subject>Biological and medical sciences</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - ethnology</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hospitalization</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases - epidemiology</subject><subject>Infant, Newborn, Diseases - ethnology</subject><subject>Infant, Premature</subject><subject>Infectious diseases</subject><subject>Israel - epidemiology</subject><subject>Jews - statistics & numerical data</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - ethnology</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prospective Studies</subject><subject>Respiratory Syncytial Virus Infections - epidemiology</subject><subject>Respiratory Syncytial Virus Infections - ethnology</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Risk Factors</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhDRDyBokFKXbsOMmyjGgZqQJU_pbRjXOjmnHsqe1QZccTsOENeRKMZvgRC-7mbr5zztU9hDzk7ISztn62eXV2wv4eLtgtsuKVKAvWNvVtsmJNywuhVHNE7sX4KTNCcnaXHJWSy4rXfEW-bpwOCBEHemnilo4-0EuMOxMg-bDQt4vTSzJg6QcT5lhAjF4bSDg8pWs_TbMzaSlAX88mZI9T-xm9hUDfOJwn7wxQ4-jGjeBSpM99cBQSFfz7l29C0Y-I20j9SM8xJkjGu_vkzgg24oPDPibvz168W78sLl6fb9anF4UWjWIFL8sBhVaiFRoqEDBooQYmWtXWbSmRKcFhGGXT97ysYOgVilIo0KzqJfStOCZP9r674K_nnN5NJmq0Fhz6OXa8Yo0sZV2yjMo9qoOPMeDY7YKZICwdZ93PJrrcRPdvE1n26JAw9xMOv0W_Xp-BxwcAogY7BnDaxD9cI3NbSmSu2XM33iYMcWvnGwzdFYJNV_-_4QfD7aOA</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Greenberg, David</creator><creator>Dagan, Ron</creator><creator>Shany, Eilon</creator><creator>Bar-Ziv, Jacob</creator><creator>Givon-Lavi, Noga</creator><general>by Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Increased Risk for Respiratory Syncytial Virus-associated, Community-acquired Alveolar Pneumonia in Infants Born at 31–36 Weeks of Gestation</title><author>Greenberg, David ; Dagan, Ron ; Shany, Eilon ; Bar-Ziv, Jacob ; Givon-Lavi, Noga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3860-122de3c6393ca5a3adc36d039697924e0631adf48bb125adb6e3236ac05b4ab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Arabs - statistics & numerical data</topic><topic>Biological and medical sciences</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Community-Acquired Infections - ethnology</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hospitalization</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases - epidemiology</topic><topic>Infant, Newborn, Diseases - ethnology</topic><topic>Infant, Premature</topic><topic>Infectious diseases</topic><topic>Israel - epidemiology</topic><topic>Jews - statistics & numerical data</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Pneumonia, Viral - ethnology</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prospective Studies</topic><topic>Respiratory Syncytial Virus Infections - epidemiology</topic><topic>Respiratory Syncytial Virus Infections - ethnology</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Risk Factors</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenberg, David</creatorcontrib><creatorcontrib>Dagan, Ron</creatorcontrib><creatorcontrib>Shany, Eilon</creatorcontrib><creatorcontrib>Bar-Ziv, Jacob</creatorcontrib><creatorcontrib>Givon-Lavi, Noga</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenberg, David</au><au>Dagan, Ron</au><au>Shany, Eilon</au><au>Bar-Ziv, Jacob</au><au>Givon-Lavi, Noga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Risk for Respiratory Syncytial Virus-associated, Community-acquired Alveolar Pneumonia in Infants Born at 31–36 Weeks of Gestation</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2014-04</date><risdate>2014</risdate><volume>33</volume><issue>4</issue><spage>381</spage><epage>386</epage><pages>381-386</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>BACKGROUND:We compared hospitalization and pediatric intensive care unit (PICU) admission rates for community-acquired alveolar pneumonia (CAAP) and respiratory syncytial virus (RSV)-associated CAAP (RSV-CAAP) in non-RSV–immunized children <24-month-old born at 31–36 weeks gestational age (GA) versus those born at term (>36 weeks GA).
METHODS:Nasopharyngeal samples for RSV were obtained prospectively (2004–2011) during RSV season, from hospitalized children with radiographic-diagnosed CAAP. Soroka University Medical Center is the only hospital in the region, enabling population-based rate calculation. Relative risks (RR) and 95% confidence intervals (95% CI) were calculated comparing RSV-CAAP incidence in 31–36 weeks GA with >36 weeks GA children.
RESULTS:CAAP hospitalization incidences (per 1000 population) were 23.6 and 9.4 (RR2.52; 95% CI2.13–2.68), respectively; the respective incidences of PICU admission for overall CAAP were 1.8 and 0.2 (RR7.88; 95% CI4.59–11.83). The RRs (and 95% CI) for RSV-CAAP hospitalizations and PICU admission rates were (after extrapolation) 15.2 and 5.8 (RR2.79; 95% CI2.31–3.06) and 1.1 and 0.1 (RR9.14; 95% CI4.93–16.96), respectively. In a multiregression analysis in patients with RSV-CAAP versus CAAP, 31–36 weeks GA was an independent risk factor for hospitalization (RR1.485; 95% CI1.03–2.14).
CONCLUSIONS:Children <24-month-old born at 31–36 weeks GA are at increased risk for hospitalization and PICU admission for both overall CAAP and RSV-associated CAAP compared with those born at >36 weeks GA. Moreover, in late premature children, RSV represented a 50% increased risk for CAAP compared with infants born at term.</abstract><cop>Hagerstown, MD</cop><pub>by Lippincott Williams & Wilkins, Inc</pub><pmid>24145171</pmid><doi>10.1097/INF.0000000000000130</doi><tpages>6</tpages></addata></record> |
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| subjects | Arabs - statistics & numerical data Biological and medical sciences Community-Acquired Infections - epidemiology Community-Acquired Infections - ethnology Diseases of mother, fetus and pregnancy Female Gestational Age Gynecology. Andrology. Obstetrics Hospitalization Human viral diseases Humans Incidence Infant Infant, Newborn Infant, Newborn, Diseases - epidemiology Infant, Newborn, Diseases - ethnology Infant, Premature Infectious diseases Israel - epidemiology Jews - statistics & numerical data Male Medical sciences Pneumology Pneumonia, Viral - epidemiology Pneumonia, Viral - ethnology Pregnancy. Fetus. Placenta Prospective Studies Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - ethnology Respiratory system : syndromes and miscellaneous diseases Risk Factors Viral diseases Viral diseases of the respiratory system and ent viral diseases |
| title | Increased Risk for Respiratory Syncytial Virus-associated, Community-acquired Alveolar Pneumonia in Infants Born at 31–36 Weeks of Gestation |
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