Efficacy and safety of repeated dosing of netupitant, a neurokinin-1 receptor antagonist, in treating overactive bladder

Aim NK‐1 receptors in sensory nerves, the spinal cord and bladder smooth muscle participate in complex sensory mechanisms that regulate bladder activity. This study was designed to assess the efficacy and safety of a new NK‐1 receptor antagonist, netupitant, in patients with OAB. Methods This was a...

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Veröffentlicht in:	Neurourology and urodynamics 2014-03, Vol.33 (3), p.335-340
Hauptverfasser:	Haab, F., Braticevici, B., Krivoborodov, G., Palmas, M., Zufferli Russo, M., Pietra, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Double-Blind Method Drug Administration Schedule Europe Female Humans Male Middle Aged netupitant Neurokinin-1 Receptor Antagonists - administration & dosage Neurokinin-1 Receptor Antagonists - adverse effects Neurokinin-1 Receptor Antagonists - pharmacokinetics neurokinin-1 receptors overactive bladder Pyridines - administration & dosage Pyridines - adverse effects Pyridines - pharmacokinetics Receptors, Neurokinin-1 - drug effects Receptors, Neurokinin-1 - metabolism Time Factors Treatment Outcome Urinary Bladder - drug effects Urinary Bladder - metabolism Urinary Bladder - physiopathology Urinary Bladder, Overactive - diagnosis Urinary Bladder, Overactive - drug therapy Urinary Bladder, Overactive - metabolism Urinary Bladder, Overactive - physiopathology Urinary Incontinence, Urge - diagnosis Urinary Incontinence, Urge - drug therapy Urinary Incontinence, Urge - metabolism Urinary Incontinence, Urge - physiopathology Urodynamics - drug effects Urological Agents - administration & dosage Urological Agents - adverse effects Young Adult
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