mGlu(2) receptor-mediated modulation of conditioned avoidance behavior in rats

Inhibition of conditioned avoidance behavior in rats is generally considered predictive for antipsychotic activity in man. The present study investigated the mGlu2-mediated modulation of conditioned avoidance and compared mGlu2 agonists with available antipsychotics for their relative effects on con...

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Veröffentlicht in:	European journal of pharmacology 2014-03, Vol.727, p.130-139
Hauptverfasser:	Megens, Anton A H P, Hendrickx, Herman M R, Hens, Koen A, Talloen, Willem J-P E, Lavreysen, Hilde
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology Avoidance Learning - drug effects Behavior, Animal - drug effects Brain - drug effects Brain - metabolism Conditioning (Psychology) - drug effects Dopamine D2 Receptor Antagonists - pharmacology Dose-Response Relationship, Drug Escape Reaction - drug effects Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glutamic Acid - metabolism Male Motor Activity - drug effects Rats, Wistar Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - metabolism Reflex, Startle - drug effects
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