miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2

•Expression of miR-625 in EC specimens was significantly lower than in corresponding adjacent tissues.•Low expression of miR-625 positively correlated with the proliferation and invasion of EC cell lines in vitro.•Direct binding of miR-625 to the Sox2 3′ UTR was demonstrated.•miR-625 overexpression...

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Veröffentlicht in:	FEBS letters 2014-03, Vol.588 (6), p.915-921
Hauptverfasser:	Wang, Zhiqiang, Qiao, Qiao, Chen, Min, Li, Xianhua, Wang, Zhenjun, Liu, Chuanxin, Xie, Zongtao
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - secondary Aged Apoptosis Base Sequence Binding Sites Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - secondary Cell Line, Tumor Cell Movement Cell Proliferation Down-Regulation Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Female Gene Expression Regulation, Neoplastic Humans Invasion Male MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-625 Neoplasm Invasiveness Proliferation RNA Interference Sox2 SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism
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