Effects of maternal care on the development of midbrain dopamine pathways and reward-directed behavior in female offspring

Variation within mesolimbic dopamine (DA) pathways has significant implications for behavioral responses to rewards, and previous studies have indicated long‐term programming effects of early life stress on these pathways. In the current study, we examined the impact of natural variations in materna...

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Veröffentlicht in:	The European journal of neuroscience 2014-03, Vol.39 (6), p.946-956
Hauptverfasser:	Peña, Catherine Jensen, Neugut, Yael D., Calarco, Cali A., Champagne, Frances A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Biological and medical sciences Brain Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism conditioned place preference Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Dopamine Dopaminergic Neurons - metabolism Epigenetics Female Fundamental and applied biological sciences. Psychology Gene regulation Grooming Haloperidol High fat diet Hydroxylase Immunoreactivity Juveniles LIM-Homeodomain Proteins - genetics LIM-Homeodomain Proteins - metabolism Long Evans rats Maternal Behavior Mesencephalon Mesencephalon - growth & development Mesencephalon - metabolism Mesencephalon - physiology mesolimbic Mesolimbic system mother-infant Neurotrophic factors Nucleus accumbens Offspring Place preference conditioning Preferences Rats Rats, Long-Evans Receptors, Dopamine - genetics Receptors, Dopamine - metabolism Reinforcement Reward RNA, Messenger - genetics RNA, Messenger - metabolism Social interactions Transcription activation Transcription Factors - genetics Transcription Factors - metabolism Tyrosine 3-monooxygenase Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism tyrosine hydroxylase ventral tegmental area Ventral tegmentum Vertebrates: nervous system and sense organs Weaning
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