Postresuscitation Administration of Doxycycline Preserves Cardiac Contractile Function in Hypoxia-Reoxygenation Injury of Newborn Piglets

OBJECTIVE:Cardiac injury is common in asphyxiated neonates and is associated with matrix metalloproteinase-2 activation. Although studies have demonstrated the cardioprotective effects of matrix metalloproteinase inhibition, this has not been tested in clinically translatable models of hypoxia-reoxy...

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Veröffentlicht in:	Critical care medicine 2014-04, Vol.42 (4), p.e260-e269
Hauptverfasser:	LaBossiere, Joseph R, Pelletier, Jean-Sebastian, Ali, Mohammad A, Thiesen, Aducio, Schulz, Richard, Bigam, David L, Cheung, Po-Yin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - physiopathology Animals Animals, Newborn Cardiac Output Dose-Response Relationship, Drug Doxycycline - administration & dosage Hemodynamics Hypotension - physiopathology Matrix Metalloproteinase 2 Matrix Metalloproteinase Inhibitors - administration & dosage Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Oxidative Stress - physiology Random Allocation Resuscitation - methods Shock, Cardiogenic - physiopathology Swine Troponin I - metabolism
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