Comparison of behaviors for detection of heritable mutations
Groups of five male HA (ICR) mice were injected intraperitoneally with 60, 150, 300, or 600 mg/kg body weight of ethyl methanesulfonate (EMS) or with saline vehicle. Each male was mated to two untreated females at 2 and 5 weeks after treatment. The two successive matings utilized sperm derived from...
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| Veröffentlicht in: | Teratogenesis, carcinogenesis, and mutagenesis carcinogenesis, and mutagenesis, 1988, Vol.8 (3), p.153-160 |
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| container_title | Teratogenesis, carcinogenesis, and mutagenesis |
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| creator | Ficsor, Gyula Goldner, Lee Panda, Brahma B. |
| description | Groups of five male HA (ICR) mice were injected intraperitoneally with 60, 150, 300, or 600 mg/kg body weight of ethyl methanesulfonate (EMS) or with saline vehicle. Each male was mated to two untreated females at 2 and 5 weeks after treatment. The two successive matings utilized sperm derived from post‐ and premeiotic germ cells, respectively. Progeny were evaluated for litter size, body weight, negative geotactic response, swimming patterns, limb use while swimming, water escape time, and open‐field motor coordination activity. Body weight, geotactic response, limb use, and open‐field behavior test results demonstrated that EMS causes heritable behavior mutations in both post‐ and pre‐meiotic germ cells. Among the tests that showed inherited differences between control and treated groups, the computer‐monitored open‐field behavior test was the most definitive. |
| doi_str_mv | 10.1002/tcm.1770080304 |
| format | Article |
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Each male was mated to two untreated females at 2 and 5 weeks after treatment. The two successive matings utilized sperm derived from post‐ and premeiotic germ cells, respectively. Progeny were evaluated for litter size, body weight, negative geotactic response, swimming patterns, limb use while swimming, water escape time, and open‐field motor coordination activity. Body weight, geotactic response, limb use, and open‐field behavior test results demonstrated that EMS causes heritable behavior mutations in both post‐ and pre‐meiotic germ cells. 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Carcinog. Mutagen</addtitle><description>Groups of five male HA (ICR) mice were injected intraperitoneally with 60, 150, 300, or 600 mg/kg body weight of ethyl methanesulfonate (EMS) or with saline vehicle. Each male was mated to two untreated females at 2 and 5 weeks after treatment. The two successive matings utilized sperm derived from post‐ and premeiotic germ cells, respectively. Progeny were evaluated for litter size, body weight, negative geotactic response, swimming patterns, limb use while swimming, water escape time, and open‐field motor coordination activity. Body weight, geotactic response, limb use, and open‐field behavior test results demonstrated that EMS causes heritable behavior mutations in both post‐ and pre‐meiotic germ cells. Among the tests that showed inherited differences between control and treated groups, the computer‐monitored open‐field behavior test was the most definitive.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Chemical mutagenesis</subject><subject>ethyl methanesulfonate</subject><subject>Ethyl Methanesulfonate - toxicity</subject><subject>Female</subject><subject>General aspects. 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Methods</topic><topic>genotoxic agent</topic><topic>geotactic response</topic><topic>germ cells</topic><topic>Litter Size - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Motor Activity - drug effects</topic><topic>Mutation</topic><topic>open-field behavior test</topic><topic>Pregnancy</topic><topic>Reference Values</topic><topic>Toxicology</topic><toplevel>online_resources</toplevel><creatorcontrib>Ficsor, Gyula</creatorcontrib><creatorcontrib>Goldner, Lee</creatorcontrib><creatorcontrib>Panda, Brahma B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Teratogenesis, carcinogenesis, and mutagenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ficsor, Gyula</au><au>Goldner, Lee</au><au>Panda, Brahma B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of behaviors for detection of heritable mutations</atitle><jtitle>Teratogenesis, carcinogenesis, and mutagenesis</jtitle><addtitle>Teratog. Carcinog. Mutagen</addtitle><date>1988</date><risdate>1988</risdate><volume>8</volume><issue>3</issue><spage>153</spage><epage>160</epage><pages>153-160</pages><issn>0270-3211</issn><eissn>1520-6866</eissn><coden>TCMUD8</coden><abstract>Groups of five male HA (ICR) mice were injected intraperitoneally with 60, 150, 300, or 600 mg/kg body weight of ethyl methanesulfonate (EMS) or with saline vehicle. Each male was mated to two untreated females at 2 and 5 weeks after treatment. The two successive matings utilized sperm derived from post‐ and premeiotic germ cells, respectively. Progeny were evaluated for litter size, body weight, negative geotactic response, swimming patterns, limb use while swimming, water escape time, and open‐field motor coordination activity. Body weight, geotactic response, limb use, and open‐field behavior test results demonstrated that EMS causes heritable behavior mutations in both post‐ and pre‐meiotic germ cells. 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| ispartof | Teratogenesis, carcinogenesis, and mutagenesis, 1988, Vol.8 (3), p.153-160 |
| issn | 0270-3211 1520-6866 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Behavior, Animal - drug effects Biological and medical sciences Body Weight - drug effects Chemical mutagenesis ethyl methanesulfonate Ethyl Methanesulfonate - toxicity Female General aspects. Methods genotoxic agent geotactic response germ cells Litter Size - drug effects Male Medical sciences Mice Mice, Inbred ICR Motor Activity - drug effects Mutation open-field behavior test Pregnancy Reference Values Toxicology |
| title | Comparison of behaviors for detection of heritable mutations |
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