Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats
Buspirone, gepirone and ipsaperone administered intraperitoneally (40 mg/kg) to naive rats were found to be proconvulsive for strychnine-induced seizures. The dose of strychnine required to induce seizures in 50% of test animals (CD 50) was 2.18 mg/kg in naive rats, while CD 50s for rats treated wit...
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| Veröffentlicht in: | European journal of pharmacology 1988-10, Vol.155 (3), p.279-283 |
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| creator | Anderson, Melissa C. Chung, Eunyong Van Woert, Melvin H. |
| description | Buspirone, gepirone and ipsaperone administered intraperitoneally (40 mg/kg) to naive rats were found to be proconvulsive for strychnine-induced seizures. The dose of strychnine required to induce seizures in 50% of test animals (CD
50) was 2.18 mg/kg in naive rats, while CD
50s for rats treated with the azaspirodecanediones ipsaperone, gepirone and buspirone were 1.65, 0.97 and 0.70 mg/kg respectively. Azaspirodecanediones have high affinity for the 5-HT
1A serotonin receptor, however, the specific 5-HT
1A agonist, 8-hydroxy-2-(di-n-propyl-amino)-tetralin (8-OH-DPAT) had no effect on strychnine seizure in naive rats (CD
50 = 2.0 mg/kg). The strychnine specific proconvulsive effects of inferior olive lesions and buspirone were additive, resulting in a CD
50 of 0.1 mg/kg. This observation indicates that the buspirone-induced decrease in strychnine seizure threshold does not require intact inferior olive-climbing fiber pathways. Cerebellar sites for possible azaspirodecanedione action are discussed. |
| doi_str_mv | 10.1016/0014-2999(88)90514-6 |
| format | Article |
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50) was 2.18 mg/kg in naive rats, while CD
50s for rats treated with the azaspirodecanediones ipsaperone, gepirone and buspirone were 1.65, 0.97 and 0.70 mg/kg respectively. Azaspirodecanediones have high affinity for the 5-HT
1A serotonin receptor, however, the specific 5-HT
1A agonist, 8-hydroxy-2-(di-n-propyl-amino)-tetralin (8-OH-DPAT) had no effect on strychnine seizure in naive rats (CD
50 = 2.0 mg/kg). The strychnine specific proconvulsive effects of inferior olive lesions and buspirone were additive, resulting in a CD
50 of 0.1 mg/kg. This observation indicates that the buspirone-induced decrease in strychnine seizure threshold does not require intact inferior olive-climbing fiber pathways. Cerebellar sites for possible azaspirodecanedione action are discussed.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(88)90514-6</identifier><identifier>PMID: 2906877</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>5-HT 1A receptors ; Animals ; Anti-Anxiety Agents - toxicity ; Biological and medical sciences ; Buspirone ; Buspirone - toxicity ; Drug Synergism ; Gepirone ; Inferior olive ; Ipsaperone ; Male ; Medical sciences ; Neuropharmacology ; Olivary Nucleus - drug effects ; Pharmacology. Drug treatments ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Pyridines - toxicity ; Pyrimidines - toxicity ; Rats ; Rats, Inbred Strains ; Receptors, Serotonin - drug effects ; Seizures - chemically induced ; Strychnine ; Strychnine seizures ; Syndrome</subject><ispartof>European journal of pharmacology, 1988-10, Vol.155 (3), p.279-283</ispartof><rights>1988</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-8c81e8dee29c55218be035f7c7f02735f0f3d8c28720bf03fb19a88c0fd34e873</citedby><cites>FETCH-LOGICAL-c417t-8c81e8dee29c55218be035f7c7f02735f0f3d8c28720bf03fb19a88c0fd34e873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(88)90514-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6625160$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2906877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Melissa C.</creatorcontrib><creatorcontrib>Chung, Eunyong</creatorcontrib><creatorcontrib>Van Woert, Melvin H.</creatorcontrib><title>Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Buspirone, gepirone and ipsaperone administered intraperitoneally (40 mg/kg) to naive rats were found to be proconvulsive for strychnine-induced seizures. The dose of strychnine required to induce seizures in 50% of test animals (CD
50) was 2.18 mg/kg in naive rats, while CD
50s for rats treated with the azaspirodecanediones ipsaperone, gepirone and buspirone were 1.65, 0.97 and 0.70 mg/kg respectively. Azaspirodecanediones have high affinity for the 5-HT
1A serotonin receptor, however, the specific 5-HT
1A agonist, 8-hydroxy-2-(di-n-propyl-amino)-tetralin (8-OH-DPAT) had no effect on strychnine seizure in naive rats (CD
50 = 2.0 mg/kg). The strychnine specific proconvulsive effects of inferior olive lesions and buspirone were additive, resulting in a CD
50 of 0.1 mg/kg. This observation indicates that the buspirone-induced decrease in strychnine seizure threshold does not require intact inferior olive-climbing fiber pathways. Cerebellar sites for possible azaspirodecanedione action are discussed.</description><subject>5-HT 1A receptors</subject><subject>Animals</subject><subject>Anti-Anxiety Agents - toxicity</subject><subject>Biological and medical sciences</subject><subject>Buspirone</subject><subject>Buspirone - toxicity</subject><subject>Drug Synergism</subject><subject>Gepirone</subject><subject>Inferior olive</subject><subject>Ipsaperone</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Olivary Nucleus - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Pyridines - toxicity</subject><subject>Pyrimidines - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Seizures - chemically induced</subject><subject>Strychnine</subject><subject>Strychnine seizures</subject><subject>Syndrome</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrGzEQgEVpcZw0_6CBPZSQHDYdaVcr6RIIIY-GQA9tzkKrHVGFtdaR5FL711eujY85zeubYfgI-ULhigLtvgHQtmZKqQspLxXwUnUfyJxKoWoQlH0k8wNyRI5TegUArhifkRlT0Ekh5uTpZ45r-zv4gFVCv1lFrJZTxpC9yX4KVb-uzMakpY_TgNYEHEoXKxP--mlcZ29T5UMVTU6fySdnxoSn-3hCXu7vft0-1s8_Hr7f3jzXtqUi19JKinJAZMpyzqjsERruhBUOmCgZuGaQlknBoHfQuJ4qI6UFNzQtStGckPPd3WWc3laYsl74ZHEcy3PTKmnKQbIWeAHbHWjjlFJEp5fRL0xcawp6q1Bv_eitHy2l_q9Qd2XtbH9_1S9wOCztnZX51_3cJGtGF02wPh2wrmOcdlCw6x2GxcUfj1En6zHYIjCizXqY_Pt__AN2w431</recordid><startdate>19881018</startdate><enddate>19881018</enddate><creator>Anderson, Melissa C.</creator><creator>Chung, Eunyong</creator><creator>Van Woert, Melvin H.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19881018</creationdate><title>Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats</title><author>Anderson, Melissa C. ; Chung, Eunyong ; Van Woert, Melvin H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8c81e8dee29c55218be035f7c7f02735f0f3d8c28720bf03fb19a88c0fd34e873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>5-HT 1A receptors</topic><topic>Animals</topic><topic>Anti-Anxiety Agents - toxicity</topic><topic>Biological and medical sciences</topic><topic>Buspirone</topic><topic>Buspirone - toxicity</topic><topic>Drug Synergism</topic><topic>Gepirone</topic><topic>Inferior olive</topic><topic>Ipsaperone</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Olivary Nucleus - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Pyridines - toxicity</topic><topic>Pyrimidines - toxicity</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Seizures - chemically induced</topic><topic>Strychnine</topic><topic>Strychnine seizures</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Melissa C.</creatorcontrib><creatorcontrib>Chung, Eunyong</creatorcontrib><creatorcontrib>Van Woert, Melvin H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Melissa C.</au><au>Chung, Eunyong</au><au>Van Woert, Melvin H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1988-10-18</date><risdate>1988</risdate><volume>155</volume><issue>3</issue><spage>279</spage><epage>283</epage><pages>279-283</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Buspirone, gepirone and ipsaperone administered intraperitoneally (40 mg/kg) to naive rats were found to be proconvulsive for strychnine-induced seizures. The dose of strychnine required to induce seizures in 50% of test animals (CD
50) was 2.18 mg/kg in naive rats, while CD
50s for rats treated with the azaspirodecanediones ipsaperone, gepirone and buspirone were 1.65, 0.97 and 0.70 mg/kg respectively. Azaspirodecanediones have high affinity for the 5-HT
1A serotonin receptor, however, the specific 5-HT
1A agonist, 8-hydroxy-2-(di-n-propyl-amino)-tetralin (8-OH-DPAT) had no effect on strychnine seizure in naive rats (CD
50 = 2.0 mg/kg). The strychnine specific proconvulsive effects of inferior olive lesions and buspirone were additive, resulting in a CD
50 of 0.1 mg/kg. This observation indicates that the buspirone-induced decrease in strychnine seizure threshold does not require intact inferior olive-climbing fiber pathways. Cerebellar sites for possible azaspirodecanedione action are discussed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2906877</pmid><doi>10.1016/0014-2999(88)90514-6</doi><tpages>5</tpages></addata></record> |
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| subjects | 5-HT 1A receptors Animals Anti-Anxiety Agents - toxicity Biological and medical sciences Buspirone Buspirone - toxicity Drug Synergism Gepirone Inferior olive Ipsaperone Male Medical sciences Neuropharmacology Olivary Nucleus - drug effects Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyridines - toxicity Pyrimidines - toxicity Rats Rats, Inbred Strains Receptors, Serotonin - drug effects Seizures - chemically induced Strychnine Strychnine seizures Syndrome |
| title | Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats |
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