Discovery of Hepatitis C Virus NS3-4A Protease Inhibitors with Improved Barrier to Resistance and Favorable Liver Distribution

Given the emergence of resistance observed for the current clinical-stage hepatitis C virus (HCV) NS3 protease inhibitors, there is a need for new inhibitors with a higher barrier to resistance. We recently reported our rational approach to the discovery of macrocyclic acylsulfonamides as HCV protea...

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Veröffentlicht in:	Journal of medicinal chemistry 2014-03, Vol.57 (5), p.1770-1776
Hauptverfasser:	Moreau, Benoît, O’Meara, Jeff A., Bordeleau, Josée, Garneau, Michel, Godbout, Cedrickx, Gorys, Vida, Leblanc, Mélissa, Villemure, Elisia, White, Peter W., Llinàs-Brunet, Montse
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Humans Liver - metabolism Magnetic Resonance Spectroscopy Protease Inhibitors - chemistry Protease Inhibitors - pharmacokinetics Protease Inhibitors - pharmacology Spectrometry, Mass, Electrospray Ionization Viral Nonstructural Proteins - antagonists & inhibitors
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