Organocatalytic [4 + 2] cyclocondensation of α,β-unsaturated acyl chlorides with imines: highly enantioselective synthesis of dihydropyridinone and piperidine derivatives

The cinchona alkaloid-catalyzed [4 + 2] cyclocondensation of α,β-unsaturated acyl chlorides with imines is developed to give the corresponding substituted dihydropyridinones in good yields with high to excellent enantioselectivities. Reduction of the dihydropyridinones gave highly optically active s...

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Veröffentlicht in:	Organic & biomolecular chemistry 2014-04, Vol.12 (14), p.2167-2171
Hauptverfasser:	Jia, Wen-Qiang, Chen, Xiang-Yu, Sun, Li-Hui, Ye, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Cinchona Alkaloids - chemistry Cyclization Dihydropyridines - chemical synthesis Dihydropyridines - chemistry Hydrocarbons, Chlorinated - chemistry Imines - chemistry Molecular Structure Piperidines - chemical synthesis Piperidines - chemistry Pyridones - chemical synthesis Pyridones - chemistry Stereoisomerism
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