Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel 18F-Folate Radiotracer

Folate receptor β (FR-β) is overexpressed on activated, but not resting, macrophages involved in a variety of inflammatory and autoimmune diseases. A pivotal step in atherogenesis is the subendothelial accumulation of macrophages. In nascent lesions, they coordinate the scavenging of lipids and cell...

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Veröffentlicht in:	Molecular imaging 2014, Vol.13 (2), p.1-11
Hauptverfasser:	Müller, Adrienne, Beck, Katharina, Rancic, Zoran, Müller, Cristina, Fischer, Cindy R., Betzel, Thomas, Kaufmann, Philipp A., Schibli, Roger, Kramer, Stefanie D., Ametamey, Simon M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Arteries - chemistry Arteries - metabolism Female Fluorodeoxyglucose F18 - chemistry Fluorodeoxyglucose F18 - pharmacokinetics Folate Receptor 2 - analysis Folate Receptor 2 - chemistry Folate Receptor 2 - genetics Folate Receptor 2 - metabolism Humans Immunohistochemistry Inflammation - metabolism Male Mice Middle Aged Models, Biological Molecular Imaging - methods Plaque, Atherosclerotic - chemistry Plaque, Atherosclerotic - metabolism
Online-Zugang:	Volltext
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