Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena
J. E. Eriksson, J. A. O. Meriluoto, H. P. Kujari, K. Österlund K. Fagerlund and L. Hällbom. Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena. Toxicon 26, 161 – 166, 1988. — A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high pe...
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| Veröffentlicht in: | Toxicon (Oxford) 1988, Vol.26 (2), p.161-166 |
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| container_title | Toxicon (Oxford) |
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| creator | Eriksson, J.E. Meriluoto, J.A.O. Kujari, H.P. Österlund, K. Fagerlund, K. HÄllbom, L. |
| description | J. E.
Eriksson, J. A. O.
Meriluoto, H. P.
Kujari, K.
Österlund K.
Fagerlund and L.
Hällbom. Preliminary characterization of a toxin isolated from the cyanobacterium
Nodularia spumigena.
Toxicon
26, 161 – 166, 1988. — A peptide toxin was isolated from the cyanobacterium
Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p.
ld
50 of the toxin was 50 μg/kg mouse with death within 1 – 3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, β-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium
Microcystis aeruginosa. |
| doi_str_mv | 10.1016/0041-0101(88)90168-7 |
| format | Article |
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Eriksson, J. A. O.
Meriluoto, H. P.
Kujari, K.
Österlund K.
Fagerlund and L.
Hällbom. Preliminary characterization of a toxin isolated from the cyanobacterium
Nodularia spumigena.
Toxicon
26, 161 – 166, 1988. — A peptide toxin was isolated from the cyanobacterium
Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p.
ld
50 of the toxin was 50 μg/kg mouse with death within 1 – 3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, β-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium
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Eriksson, J. A. O.
Meriluoto, H. P.
Kujari, K.
Österlund K.
Fagerlund and L.
Hällbom. Preliminary characterization of a toxin isolated from the cyanobacterium
Nodularia spumigena.
Toxicon
26, 161 – 166, 1988. — A peptide toxin was isolated from the cyanobacterium
Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p.
ld
50 of the toxin was 50 μg/kg mouse with death within 1 – 3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, β-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium
Microcystis aeruginosa.</description><subject>Amino Acids - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brackish</subject><subject>characterization</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cyanobacteria</subject><subject>Cyanobacteria - analysis</subject><subject>Freshwater</subject><subject>hemorrhage</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Marine</subject><subject>Marine Toxins - isolation & purification</subject><subject>Marine Toxins - toxicity</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Microcystis aeruginosa</subject><subject>Nodularia spumigena</subject><subject>Plant poisons toxicology</subject><subject>poisoning</subject><subject>Spectrophotometry, Infrared</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Toxicology</subject><subject>toxins</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1EVbaFfwDCB1TBIeCvxM4Fqar4kipAgt6QrIkzbo2SeGsnVcuvx0tWe-Tkkd9nRjMPIc85e8sZb94xpnjFSvnamDdt-TGVfkQ23Oi2krxmj8nmgDwhJzn_ZoxJ0zbH5Fhy0RpRb8iv7wmHMIYJ0gN1N5DAzZjCH5hDnGj0FOgc78NEQ44DzNhTn-JI5xuk7gGm2K38MtKvsV8GSAFo3i5juMYJnpIjD0PGZ_v3lFx9_PDz4nN1-e3Tl4vzy8opxefKCVDY9sJo9MqBYLVUyBteSq5042TdtZ51Xtaiw5L1jMuW9Y1C5lzHQZ6Ss3XuNsXbBfNsx5AdDgNMGJdsiwwtlWIFVCvoUsw5obfbFMZyuuXM7qTanTG7M2aNsf-kWl3aXuznL92I_aFpb7Hkr_Y5ZAeDTzC5kA-YNrxpa1WwlyvmIVq4TgW5-iHKMUwwXSstCvF-JbDYuguYbHYBJ4d9SOhm28fw_03_AmBLnOw</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Eriksson, J.E.</creator><creator>Meriluoto, J.A.O.</creator><creator>Kujari, H.P.</creator><creator>Österlund, K.</creator><creator>Fagerlund, K.</creator><creator>HÄllbom, L.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope></search><sort><creationdate>1988</creationdate><title>Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena</title><author>Eriksson, J.E. ; Meriluoto, J.A.O. ; Kujari, H.P. ; Österlund, K. ; Fagerlund, K. ; HÄllbom, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-c2a4e9d287ef4ca20534e161ca21476c35b9f0bf352be534d01390d64e0ccb1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acids - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brackish</topic><topic>characterization</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cyanobacteria</topic><topic>Cyanobacteria - analysis</topic><topic>Freshwater</topic><topic>hemorrhage</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>Marine</topic><topic>Marine Toxins - isolation & purification</topic><topic>Marine Toxins - toxicity</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Microcystis aeruginosa</topic><topic>Nodularia spumigena</topic><topic>Plant poisons toxicology</topic><topic>poisoning</topic><topic>Spectrophotometry, Infrared</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Toxicology</topic><topic>toxins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eriksson, J.E.</creatorcontrib><creatorcontrib>Meriluoto, J.A.O.</creatorcontrib><creatorcontrib>Kujari, H.P.</creatorcontrib><creatorcontrib>Österlund, K.</creatorcontrib><creatorcontrib>Fagerlund, K.</creatorcontrib><creatorcontrib>HÄllbom, L.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eriksson, J.E.</au><au>Meriluoto, J.A.O.</au><au>Kujari, H.P.</au><au>Österlund, K.</au><au>Fagerlund, K.</au><au>HÄllbom, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1988</date><risdate>1988</risdate><volume>26</volume><issue>2</issue><spage>161</spage><epage>166</epage><pages>161-166</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>J. E.
Eriksson, J. A. O.
Meriluoto, H. P.
Kujari, K.
Österlund K.
Fagerlund and L.
Hällbom. Preliminary characterization of a toxin isolated from the cyanobacterium
Nodularia spumigena.
Toxicon
26, 161 – 166, 1988. — A peptide toxin was isolated from the cyanobacterium
Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p.
ld
50 of the toxin was 50 μg/kg mouse with death within 1 – 3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, β-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium
Microcystis aeruginosa.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3129825</pmid><doi>10.1016/0041-0101(88)90168-7</doi><tpages>6</tpages></addata></record> |
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| ispartof | Toxicon (Oxford), 1988, Vol.26 (2), p.161-166 |
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| subjects | Amino Acids - analysis Animals Biological and medical sciences Brackish characterization Chromatography, High Pressure Liquid Cyanobacteria Cyanobacteria - analysis Freshwater hemorrhage Lethal Dose 50 Male Marine Marine Toxins - isolation & purification Marine Toxins - toxicity Medical sciences Mice Mice, Inbred Strains Microcystis aeruginosa Nodularia spumigena Plant poisons toxicology poisoning Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Toxicology toxins |
| title | Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena |
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