Development of a theory for generating regional cardiac perfusion images during coronary angiography in the coronary angiography lab
The purpose of this study was to develop a novel theory and method for generating regional myocardial perfusion images using fluoroscopy in the coronary angiography lab. We modified the Kety model to introduce the Patlak plot method for two-dimensional fluoroperfusion (FP) imaging. For evaluation, s...
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| Veröffentlicht in: | The International Journal of Cardiovascular Imaging 2014-01, Vol.30 (1), p.9-19 |
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| creator | Sakaguchi, Takuya Ichihara, Takashi Trost, Jeffrey C. Yousuf, Omair Lima, Joao A. C. Yao, Jingwu George, Richard T. |
| description | The purpose of this study was to develop a novel theory and method for generating regional myocardial perfusion images using fluoroscopy in the coronary angiography lab. We modified the Kety model to introduce the Patlak plot method for two-dimensional fluoroperfusion (FP) imaging. For evaluation, seven porcine models of myocardial ischemia with stenosis in the left coronary artery were prepared. Rest and stress FP imaging were performed using cardiovascular X-ray imaging equipment during the injection of iopamidol via the left main coronary artery. Images were acquired and retrospectively ECG gated at 80 % of the R–R interval. FP myocardial blood flow (MBF) was obtained using the Patlak plot method applied to time-intensity curve data of the proximal artery and myocardium. The results were compared to microsphere MBF measurements. Time-intensity curves were also used to generate color-coded FP maps. There was a moderate linear correlation between the calculated FP MBF and the microsphere MBF (y = 0.9758x + 0.5368, R
2
= 0.61). The color-coded FP maps were moderately correlated with the regional distribution of flow. This novel method of first-pass contrast-enhanced two-dimensional fluoroscopic imaging can quantify MBF and provide color coded FP maps representing regional myocardial perfusion. |
| doi_str_mv | 10.1007/s10554-013-0304-9 |
| format | Article |
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2
= 0.61). The color-coded FP maps were moderately correlated with the regional distribution of flow. This novel method of first-pass contrast-enhanced two-dimensional fluoroscopic imaging can quantify MBF and provide color coded FP maps representing regional myocardial perfusion.</description><identifier>ISSN: 1569-5794</identifier><identifier>EISSN: 1573-0743</identifier><identifier>EISSN: 1875-8312</identifier><identifier>DOI: 10.1007/s10554-013-0304-9</identifier><identifier>PMID: 24122453</identifier><identifier>CODEN: IJCIBI</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Animals ; Cardiac Imaging ; Cardiac-Gated Imaging Techniques ; Cardiology ; Contrast Media ; Coronary Angiography ; Coronary Circulation ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - physiopathology ; Coronary Vessels - diagnostic imaging ; Coronary Vessels - physiopathology ; Disease Models, Animal ; Electrocardiography ; Fluoroscopy ; Imaging ; Iopamidol ; Linear Models ; Medicine ; Medicine & Public Health ; Models, Cardiovascular ; Myocardial Perfusion Imaging - methods ; Original Paper ; Predictive Value of Tests ; Radiographic Image Interpretation, Computer-Assisted ; Radiology ; Swine ; Time Factors</subject><ispartof>The International Journal of Cardiovascular Imaging, 2014-01, Vol.30 (1), p.9-19</ispartof><rights>Springer Science+Business Media Dordrecht 2013</rights><rights>Springer Science+Business Media Dordrecht 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-a832206e691947be0010a1c22f63b8b63bee5d824e720e811eca1d751bb3fdab3</citedby><cites>FETCH-LOGICAL-c438t-a832206e691947be0010a1c22f63b8b63bee5d824e720e811eca1d751bb3fdab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10554-013-0304-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10554-013-0304-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24122453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakaguchi, Takuya</creatorcontrib><creatorcontrib>Ichihara, Takashi</creatorcontrib><creatorcontrib>Trost, Jeffrey C.</creatorcontrib><creatorcontrib>Yousuf, Omair</creatorcontrib><creatorcontrib>Lima, Joao A. C.</creatorcontrib><creatorcontrib>Yao, Jingwu</creatorcontrib><creatorcontrib>George, Richard T.</creatorcontrib><title>Development of a theory for generating regional cardiac perfusion images during coronary angiography in the coronary angiography lab</title><title>The International Journal of Cardiovascular Imaging</title><addtitle>Int J Cardiovasc Imaging</addtitle><addtitle>Int J Cardiovasc Imaging</addtitle><description>The purpose of this study was to develop a novel theory and method for generating regional myocardial perfusion images using fluoroscopy in the coronary angiography lab. We modified the Kety model to introduce the Patlak plot method for two-dimensional fluoroperfusion (FP) imaging. For evaluation, seven porcine models of myocardial ischemia with stenosis in the left coronary artery were prepared. Rest and stress FP imaging were performed using cardiovascular X-ray imaging equipment during the injection of iopamidol via the left main coronary artery. Images were acquired and retrospectively ECG gated at 80 % of the R–R interval. FP myocardial blood flow (MBF) was obtained using the Patlak plot method applied to time-intensity curve data of the proximal artery and myocardium. The results were compared to microsphere MBF measurements. Time-intensity curves were also used to generate color-coded FP maps. There was a moderate linear correlation between the calculated FP MBF and the microsphere MBF (y = 0.9758x + 0.5368, R
2
= 0.61). The color-coded FP maps were moderately correlated with the regional distribution of flow. This novel method of first-pass contrast-enhanced two-dimensional fluoroscopic imaging can quantify MBF and provide color coded FP maps representing regional myocardial perfusion.</description><subject>Animals</subject><subject>Cardiac Imaging</subject><subject>Cardiac-Gated Imaging Techniques</subject><subject>Cardiology</subject><subject>Contrast Media</subject><subject>Coronary Angiography</subject><subject>Coronary Circulation</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - physiopathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Coronary Vessels - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Electrocardiography</subject><subject>Fluoroscopy</subject><subject>Imaging</subject><subject>Iopamidol</subject><subject>Linear Models</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Models, Cardiovascular</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Original Paper</subject><subject>Predictive Value of Tests</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Radiology</subject><subject>Swine</subject><subject>Time Factors</subject><issn>1569-5794</issn><issn>1573-0743</issn><issn>1875-8312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kctKxTAQhoMoXo4-gBsJuHFTnUnS21K8g-BG1yFtp7XS09SkFc7eBzflqIjoJskk33yB-Rk7RDhFgPTMI8SxigBlBBJUlG-wXYzTUKVKbs7nJI_iNFc7bM_7FwAQIOQ22xEKhVCx3GXvl_RGnR2W1I_c1tzw8ZmsW_HaOt5QT86Mbd9wR01re9Px0riqNSUfyNWTD3e8XZqGPK8mN4OldYELAtOHjsaZ4XnF237W_v3WmWKfbdWm83TwuS_Y0_XV48VtdP9wc3dxfh-VSmZjZDIpBCSU5JirtCAABIOlEHUii6wIC1FcZUJRKoAyRCoNVmmMRSHryhRywU7W3sHZ14n8qJetL6nrTE928hpjSDHLgjegx7_QFzu5MIBAqVwIlCJJAoVrqnTWe0e1HlwYh1tpBD1HpNcR6WDUc0Q6Dz1Hn-apWFL13fGVSQDEGvDDPFFyP77-1_oBJtadwQ</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Sakaguchi, Takuya</creator><creator>Ichihara, Takashi</creator><creator>Trost, Jeffrey C.</creator><creator>Yousuf, Omair</creator><creator>Lima, Joao A. 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C. ; Yao, Jingwu ; George, Richard T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-a832206e691947be0010a1c22f63b8b63bee5d824e720e811eca1d751bb3fdab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Cardiac Imaging</topic><topic>Cardiac-Gated Imaging Techniques</topic><topic>Cardiology</topic><topic>Contrast Media</topic><topic>Coronary Angiography</topic><topic>Coronary Circulation</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Coronary Stenosis - physiopathology</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Coronary Vessels - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Electrocardiography</topic><topic>Fluoroscopy</topic><topic>Imaging</topic><topic>Iopamidol</topic><topic>Linear Models</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Models, Cardiovascular</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>Original Paper</topic><topic>Predictive Value of Tests</topic><topic>Radiographic Image Interpretation, Computer-Assisted</topic><topic>Radiology</topic><topic>Swine</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakaguchi, Takuya</creatorcontrib><creatorcontrib>Ichihara, Takashi</creatorcontrib><creatorcontrib>Trost, Jeffrey C.</creatorcontrib><creatorcontrib>Yousuf, Omair</creatorcontrib><creatorcontrib>Lima, Joao A. C.</creatorcontrib><creatorcontrib>Yao, Jingwu</creatorcontrib><creatorcontrib>George, Richard T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The International Journal of Cardiovascular Imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakaguchi, Takuya</au><au>Ichihara, Takashi</au><au>Trost, Jeffrey C.</au><au>Yousuf, Omair</au><au>Lima, Joao A. C.</au><au>Yao, Jingwu</au><au>George, Richard T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a theory for generating regional cardiac perfusion images during coronary angiography in the coronary angiography lab</atitle><jtitle>The International Journal of Cardiovascular Imaging</jtitle><stitle>Int J Cardiovasc Imaging</stitle><addtitle>Int J Cardiovasc Imaging</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>30</volume><issue>1</issue><spage>9</spage><epage>19</epage><pages>9-19</pages><issn>1569-5794</issn><eissn>1573-0743</eissn><eissn>1875-8312</eissn><coden>IJCIBI</coden><abstract>The purpose of this study was to develop a novel theory and method for generating regional myocardial perfusion images using fluoroscopy in the coronary angiography lab. We modified the Kety model to introduce the Patlak plot method for two-dimensional fluoroperfusion (FP) imaging. For evaluation, seven porcine models of myocardial ischemia with stenosis in the left coronary artery were prepared. Rest and stress FP imaging were performed using cardiovascular X-ray imaging equipment during the injection of iopamidol via the left main coronary artery. Images were acquired and retrospectively ECG gated at 80 % of the R–R interval. FP myocardial blood flow (MBF) was obtained using the Patlak plot method applied to time-intensity curve data of the proximal artery and myocardium. The results were compared to microsphere MBF measurements. Time-intensity curves were also used to generate color-coded FP maps. There was a moderate linear correlation between the calculated FP MBF and the microsphere MBF (y = 0.9758x + 0.5368, R
2
= 0.61). The color-coded FP maps were moderately correlated with the regional distribution of flow. This novel method of first-pass contrast-enhanced two-dimensional fluoroscopic imaging can quantify MBF and provide color coded FP maps representing regional myocardial perfusion.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24122453</pmid><doi>10.1007/s10554-013-0304-9</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Cardiac Imaging Cardiac-Gated Imaging Techniques Cardiology Contrast Media Coronary Angiography Coronary Circulation Coronary Stenosis - diagnostic imaging Coronary Stenosis - physiopathology Coronary Vessels - diagnostic imaging Coronary Vessels - physiopathology Disease Models, Animal Electrocardiography Fluoroscopy Imaging Iopamidol Linear Models Medicine Medicine & Public Health Models, Cardiovascular Myocardial Perfusion Imaging - methods Original Paper Predictive Value of Tests Radiographic Image Interpretation, Computer-Assisted Radiology Swine Time Factors |
| title | Development of a theory for generating regional cardiac perfusion images during coronary angiography in the coronary angiography lab |
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