Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence

The earliest HSCs are derived from haemogenic endothelium via endothelial-to-haematopoietic transition during vertebrate embryogenesis; however, the underlying mechanism is largely unclear. Here we show that interplay of Smad1/5 and ERK signalling is essential for haemogenic endothelium-based HSC em...

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Veröffentlicht in:	Nature communications 2014-03, Vol.5 (1), p.3431-3431, Article 3431
Hauptverfasser:	Zhang, Chunxia, Lv, Junhua, He, Qiuping, Wang, Sifeng, Gao, Ya, Meng, Anming, Yang, Xiao, Liu, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	38 631/136/532/1542 631/80/86 Animals Animals, Genetically Modified Blotting, Western Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Endothelial Cells - metabolism Endothelial Cells - ultrastructure Endothelium, Vascular - cytology Endothelium, Vascular - embryology Endothelium, Vascular - metabolism Gene Expression Regulation, Developmental Gene Knockdown Techniques Hematopoiesis - genetics Hematopoietic Stem Cells - metabolism Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Humanities and Social Sciences In Situ Hybridization Luminescent Proteins - genetics Luminescent Proteins - metabolism MAP Kinase Signaling System - genetics Microscopy, Confocal Microscopy, Electron, Transmission Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism multidisciplinary Reverse Transcriptase Polymerase Chain Reaction Science Science (multidisciplinary) Smad1 Protein - genetics Smad1 Protein - metabolism Smad5 Protein - genetics Smad5 Protein - metabolism Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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