Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice
This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of...
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| Veröffentlicht in: | Journal of Nippon Medical School 2014, Vol.81(1), pp.53-56 |
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| container_title | Journal of Nippon Medical School |
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| creator | Ise, Yuya Mori, Tomohisa Katayama, Shirou Suzuki, Tsutomu Wang, Tzu-Chueh |
| description | This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background. |
| doi_str_mv | 10.1272/jnms.81.53 |
| format | Article |
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Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.</description><identifier>ISSN: 1345-4676</identifier><identifier>EISSN: 1347-3409</identifier><identifier>DOI: 10.1272/jnms.81.53</identifier><identifier>PMID: 24614397</identifier><language>eng</language><publisher>Japan: The Medical Association of Nippon Medical School</publisher><subject>Animals ; Behavior, Animal - drug effects ; conditioned place preference paradigm ; Conditioning (Psychology) - drug effects ; genetic difference ; Male ; mecamylamine ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mice, Inbred Strains - genetics ; nicotine ; Nicotine - pharmacology ; Tobacco Use Disorder - genetics</subject><ispartof>Journal of Nippon Medical School, 2014, Vol.81(1), pp.53-56</ispartof><rights>2014 by the Medical Association of Nippon Medical School</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c673t-7b3a3b90ca052e9b46577030e6fb9ce86aef4517bcdb2d3fc11e0e1236ccf2063</citedby><cites>FETCH-LOGICAL-c673t-7b3a3b90ca052e9b46577030e6fb9ce86aef4517bcdb2d3fc11e0e1236ccf2063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24614397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ise, Yuya</creatorcontrib><creatorcontrib>Mori, Tomohisa</creatorcontrib><creatorcontrib>Katayama, Shirou</creatorcontrib><creatorcontrib>Suzuki, Tsutomu</creatorcontrib><creatorcontrib>Wang, Tzu-Chueh</creatorcontrib><creatorcontrib>Chia Nan University of Pharmacy and Science</creatorcontrib><creatorcontrib>Department of Toxicology</creatorcontrib><creatorcontrib>Section of Pharmaceutical Services</creatorcontrib><creatorcontrib>Hoshi University</creatorcontrib><creatorcontrib>Department of Pharmacy</creatorcontrib><creatorcontrib>Nippon Medical School Hospital</creatorcontrib><creatorcontrib>School of Pharmacy and Pharmaceutical Science</creatorcontrib><title>Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice</title><title>Journal of Nippon Medical School</title><addtitle>J Nippon Med Sch</addtitle><description>This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>conditioned place preference paradigm</subject><subject>Conditioning (Psychology) - drug effects</subject><subject>genetic difference</subject><subject>Male</subject><subject>mecamylamine</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Mice, Inbred Strains - genetics</subject><subject>nicotine</subject><subject>Nicotine - pharmacology</subject><subject>Tobacco Use Disorder - genetics</subject><issn>1345-4676</issn><issn>1347-3409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUFv1DAQhSMEoqVw4QegHBFSlrEd28mBQ1nBUqlAD3C2nMmkOGTtYicg_j0Oafdij8af3pt5LoqXDHaMa_529Me0a9hOikfFORO1rkQN7eP_taxqpdVZ8SylEUAIKdXT4ozXitWi1efFcCBPs8PyvcWftzEsvi-v_DAt5JFS-cVhmJ2nyvl-QerLffC9m13wub6ZLFJ5E2mguOKl9Q_Ny98UU6ZK58vPDul58WSwU6IX9_dF8f3jh2_7T9X118PV_vK6QqXFXOlOWNG1gBYkp7arldQaBJAauhapUZaGWjLdYd_xXgzIGAExLhTiwEGJi-L1pnsXw6-F0myOLiFNk_UUlmSYBKWbttY8o282FGNIKS9h7qI72vjXMDBrrmbN1TTMSJHhV_e6S3ek_oQ-BJmBwwbkV4d2Cn7KsZkxLNHnhQ3-YWNY9Tiw2gA0DJiB7AQgxXooznnTqtXq3aY0ptne0snKxvxNE52mYttopz7-sNGQF_8AHE-hig</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Ise, Yuya</creator><creator>Mori, Tomohisa</creator><creator>Katayama, Shirou</creator><creator>Suzuki, Tsutomu</creator><creator>Wang, Tzu-Chueh</creator><general>The Medical Association of Nippon Medical School</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice</title><author>Ise, Yuya ; Mori, Tomohisa ; Katayama, Shirou ; Suzuki, Tsutomu ; Wang, Tzu-Chueh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c673t-7b3a3b90ca052e9b46577030e6fb9ce86aef4517bcdb2d3fc11e0e1236ccf2063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>conditioned place preference paradigm</topic><topic>Conditioning (Psychology) - drug effects</topic><topic>genetic difference</topic><topic>Male</topic><topic>mecamylamine</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Mice, Inbred Strains - genetics</topic><topic>nicotine</topic><topic>Nicotine - pharmacology</topic><topic>Tobacco Use Disorder - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ise, Yuya</creatorcontrib><creatorcontrib>Mori, Tomohisa</creatorcontrib><creatorcontrib>Katayama, Shirou</creatorcontrib><creatorcontrib>Suzuki, Tsutomu</creatorcontrib><creatorcontrib>Wang, Tzu-Chueh</creatorcontrib><creatorcontrib>Chia Nan University of Pharmacy and Science</creatorcontrib><creatorcontrib>Department of Toxicology</creatorcontrib><creatorcontrib>Section of Pharmaceutical Services</creatorcontrib><creatorcontrib>Hoshi University</creatorcontrib><creatorcontrib>Department of Pharmacy</creatorcontrib><creatorcontrib>Nippon Medical School Hospital</creatorcontrib><creatorcontrib>School of Pharmacy and Pharmaceutical Science</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Nippon Medical School</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ise, Yuya</au><au>Mori, Tomohisa</au><au>Katayama, Shirou</au><au>Suzuki, Tsutomu</au><au>Wang, Tzu-Chueh</au><aucorp>Chia Nan University of Pharmacy and Science</aucorp><aucorp>Department of Toxicology</aucorp><aucorp>Section of Pharmaceutical Services</aucorp><aucorp>Hoshi University</aucorp><aucorp>Department of Pharmacy</aucorp><aucorp>Nippon Medical School Hospital</aucorp><aucorp>School of Pharmacy and Pharmaceutical Science</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice</atitle><jtitle>Journal of Nippon Medical School</jtitle><addtitle>J Nippon Med Sch</addtitle><date>2014</date><risdate>2014</risdate><volume>81</volume><issue>1</issue><spage>53</spage><epage>56</epage><pages>53-56</pages><issn>1345-4676</issn><eissn>1347-3409</eissn><abstract>This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). 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| ispartof | Journal of Nippon Medical School, 2014, Vol.81(1), pp.53-56 |
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| subjects | Animals Behavior, Animal - drug effects conditioned place preference paradigm Conditioning (Psychology) - drug effects genetic difference Male mecamylamine Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Mice, Inbred Strains - genetics nicotine Nicotine - pharmacology Tobacco Use Disorder - genetics |
| title | Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice |
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