Recombinant Tumor Necrosis Factor Increases Pulmonary Vascular Permeability Independent of Neutrophils

We studied the effects of intravenous infusion of recombinant human tumor necrosis factor type α (rTNF-α ; 12 μ g/kg) on lung fluid balance in sheep prepared with chronic lung lymph fistulas. The role of neutrophils was examined in sheep made neutropenic with hydroxyurea (200 mg/kg for 4 or 5 days)...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1988-12, Vol.85 (23), p.9219-9223
Hauptverfasser:	Horvath, Christopher J., Ferro, Thomas J., Jesmok, Gary, Malik, Asrar B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Blood plasma Body Temperature - drug effects Capillary Permeability - drug effects Carbon Dioxide - blood Cardiology. Vascular system Cell physiology Chronic cor pulmonale Endothelial cells Endotoxins Fibrin Fibrinogen Degradation Products - analysis Fibrinogen - metabolism Fundamental and applied biological sciences. Psychology Heart Hematocrit Hydroxyurea - pharmacology Leukocyte Count Leukocytes Lungs Lymph Male Medical sciences Molecular and cellular biology Neutropenia Neutrophils Neutrophils - physiology Oxygen - blood Pneumology Pulmonary artery Pulmonary Circulation - drug effects Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Recombinant Proteins - pharmacology Reference Values Responses to growth factors, tumor promotors, other factors Sheep Tumor Necrosis Factor-alpha - pharmacology
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