Protease-activated receptors expression in gingiva in periodontal health and disease
Abstract Objective Protease-activated receptors (PARs) are a unique class of receptors which are implicated in mediating inflammation, pain and other functions. The aim of this study was to elucidate the role of PARs in the pathogenesis of chronic periodontitis by differential expression analysis of...
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| Veröffentlicht in: | Archives of oral biology 2014-04, Vol.59 (4), p.393-399 |
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| creator | Zhang, Diya Li, Shenglai Hu, Lingjing Sheng, Lieping Cao, Zheng Wu, Yanmin Chen, Lili |
| description | Abstract Objective Protease-activated receptors (PARs) are a unique class of receptors which are implicated in mediating inflammation, pain and other functions. The aim of this study was to elucidate the role of PARs in the pathogenesis of chronic periodontitis by differential expression analysis of PARs in the gingival tissues of chronic periodontitis patients compared with those of healthy control individuals. Design Gingival tissue specimens were collected from chronic periodontitis patients ( n = 20) and control individuals ( n = 20). The expression of PAR-1, -2, -3 and -4 was determined in these tissues by immunohistochemistry and differential expression between the two groups was investigated by quantitative real-time reverse transcription-polymerase chain reaction analysis. Results PAR-1, -2, -3 and -4 were expressed in all gingival tissues. A significant overexpression of PAR-3 was detected in chronic periodontitis-affected tissues compared to healthy gingival tissues. However, expression of PAR-2 was decreased in periodontal lesions. Conclusions Our study shows that PAR-1, -2, -3 and -4 are expressed in both healthy and inflamed gingival tissues. Furthermore, PAR-2 and PAR-3 may contribute to the inflammatory responses associated with chronic periodontitis. |
| doi_str_mv | 10.1016/j.archoralbio.2014.01.006 |
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The aim of this study was to elucidate the role of PARs in the pathogenesis of chronic periodontitis by differential expression analysis of PARs in the gingival tissues of chronic periodontitis patients compared with those of healthy control individuals. Design Gingival tissue specimens were collected from chronic periodontitis patients ( n = 20) and control individuals ( n = 20). The expression of PAR-1, -2, -3 and -4 was determined in these tissues by immunohistochemistry and differential expression between the two groups was investigated by quantitative real-time reverse transcription-polymerase chain reaction analysis. Results PAR-1, -2, -3 and -4 were expressed in all gingival tissues. A significant overexpression of PAR-3 was detected in chronic periodontitis-affected tissues compared to healthy gingival tissues. However, expression of PAR-2 was decreased in periodontal lesions. Conclusions Our study shows that PAR-1, -2, -3 and -4 are expressed in both healthy and inflamed gingival tissues. Furthermore, PAR-2 and PAR-3 may contribute to the inflammatory responses associated with chronic periodontitis.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2014.01.006</identifier><identifier>PMID: 24509446</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Advanced Basic Science ; Aged ; Case-Control Studies ; Chronic periodontitis ; Chronic Periodontitis - metabolism ; Dentistry ; Female ; Gingiva ; Gingiva - metabolism ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Protease-activated receptor ; Receptors, Proteinase-Activated - metabolism ; Reverse Transcriptase Polymerase Chain Reaction</subject><ispartof>Archives of oral biology, 2014-04, Vol.59 (4), p.393-399</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-7c2accc1165500ab77d1843ed0ba8421fffe3717d7820711fe295b595ff984f63</citedby><cites>FETCH-LOGICAL-c432t-7c2accc1165500ab77d1843ed0ba8421fffe3717d7820711fe295b595ff984f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2014.01.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24509446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Diya</creatorcontrib><creatorcontrib>Li, Shenglai</creatorcontrib><creatorcontrib>Hu, Lingjing</creatorcontrib><creatorcontrib>Sheng, Lieping</creatorcontrib><creatorcontrib>Cao, Zheng</creatorcontrib><creatorcontrib>Wu, Yanmin</creatorcontrib><creatorcontrib>Chen, Lili</creatorcontrib><title>Protease-activated receptors expression in gingiva in periodontal health and disease</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Abstract Objective Protease-activated receptors (PARs) are a unique class of receptors which are implicated in mediating inflammation, pain and other functions. The aim of this study was to elucidate the role of PARs in the pathogenesis of chronic periodontitis by differential expression analysis of PARs in the gingival tissues of chronic periodontitis patients compared with those of healthy control individuals. Design Gingival tissue specimens were collected from chronic periodontitis patients ( n = 20) and control individuals ( n = 20). The expression of PAR-1, -2, -3 and -4 was determined in these tissues by immunohistochemistry and differential expression between the two groups was investigated by quantitative real-time reverse transcription-polymerase chain reaction analysis. Results PAR-1, -2, -3 and -4 were expressed in all gingival tissues. A significant overexpression of PAR-3 was detected in chronic periodontitis-affected tissues compared to healthy gingival tissues. However, expression of PAR-2 was decreased in periodontal lesions. Conclusions Our study shows that PAR-1, -2, -3 and -4 are expressed in both healthy and inflamed gingival tissues. Furthermore, PAR-2 and PAR-3 may contribute to the inflammatory responses associated with chronic periodontitis.</description><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Chronic periodontitis</subject><subject>Chronic Periodontitis - metabolism</subject><subject>Dentistry</subject><subject>Female</subject><subject>Gingiva</subject><subject>Gingiva - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Protease-activated receptor</subject><subject>Receptors, Proteinase-Activated - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi1ERZfCX0DhxiVhJnHi-IKEVuVDqlSklrPl2JOul2wcbG9F_z2OtiDEqSePpWfe0TzD2FuECgG79_tKB7PzQU-D81UNyCvACqB7xjbYC1liC91ztgGAppSyk-fsZYz7_G27Dl-w85q3IDnvNuz2W_CJdKRSm-TudSJbBDK0JB9iQb-WQDE6PxduLu7cfJeRtVwoOG_9nPRU7EhPaVfo2RbWxTXrFTsb9RTp9eN7wb5_urzdfimvrj9_3X68Kg1v6lQKU2tjDGLXtgB6EMJizxuyMOie1ziOIzUChRV9DQJxpFq2QyvbcZQ9H7vmgr075S7B_zxSTOrgoqFp0jP5Y1SrBo6il5hReUJN8DEGGtUS3EGHB4WgVqlqr_6RqlapClBlqbn3zeOY43Ag-7fzj8UMbE8A5WXvHQUVjaPZkHXZZVLWuyeN-fBfipnc7IyeftADxb0_hjnbVKhirUDdrNddj4s8VyBE8xtOD6P_</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Zhang, Diya</creator><creator>Li, Shenglai</creator><creator>Hu, Lingjing</creator><creator>Sheng, Lieping</creator><creator>Cao, Zheng</creator><creator>Wu, Yanmin</creator><creator>Chen, Lili</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Protease-activated receptors expression in gingiva in periodontal health and disease</title><author>Zhang, Diya ; Li, Shenglai ; Hu, Lingjing ; Sheng, Lieping ; Cao, Zheng ; Wu, Yanmin ; Chen, Lili</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-7c2accc1165500ab77d1843ed0ba8421fffe3717d7820711fe295b595ff984f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Chronic periodontitis</topic><topic>Chronic Periodontitis - metabolism</topic><topic>Dentistry</topic><topic>Female</topic><topic>Gingiva</topic><topic>Gingiva - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Protease-activated receptor</topic><topic>Receptors, Proteinase-Activated - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Diya</creatorcontrib><creatorcontrib>Li, Shenglai</creatorcontrib><creatorcontrib>Hu, Lingjing</creatorcontrib><creatorcontrib>Sheng, Lieping</creatorcontrib><creatorcontrib>Cao, Zheng</creatorcontrib><creatorcontrib>Wu, Yanmin</creatorcontrib><creatorcontrib>Chen, Lili</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Diya</au><au>Li, Shenglai</au><au>Hu, Lingjing</au><au>Sheng, Lieping</au><au>Cao, Zheng</au><au>Wu, Yanmin</au><au>Chen, Lili</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protease-activated receptors expression in gingiva in periodontal health and disease</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>59</volume><issue>4</issue><spage>393</spage><epage>399</epage><pages>393-399</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Abstract Objective Protease-activated receptors (PARs) are a unique class of receptors which are implicated in mediating inflammation, pain and other functions. The aim of this study was to elucidate the role of PARs in the pathogenesis of chronic periodontitis by differential expression analysis of PARs in the gingival tissues of chronic periodontitis patients compared with those of healthy control individuals. Design Gingival tissue specimens were collected from chronic periodontitis patients ( n = 20) and control individuals ( n = 20). The expression of PAR-1, -2, -3 and -4 was determined in these tissues by immunohistochemistry and differential expression between the two groups was investigated by quantitative real-time reverse transcription-polymerase chain reaction analysis. Results PAR-1, -2, -3 and -4 were expressed in all gingival tissues. A significant overexpression of PAR-3 was detected in chronic periodontitis-affected tissues compared to healthy gingival tissues. However, expression of PAR-2 was decreased in periodontal lesions. Conclusions Our study shows that PAR-1, -2, -3 and -4 are expressed in both healthy and inflamed gingival tissues. Furthermore, PAR-2 and PAR-3 may contribute to the inflammatory responses associated with chronic periodontitis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24509446</pmid><doi>10.1016/j.archoralbio.2014.01.006</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Advanced Basic Science Aged Case-Control Studies Chronic periodontitis Chronic Periodontitis - metabolism Dentistry Female Gingiva Gingiva - metabolism Humans Immunohistochemistry Male Middle Aged Protease-activated receptor Receptors, Proteinase-Activated - metabolism Reverse Transcriptase Polymerase Chain Reaction |
| title | Protease-activated receptors expression in gingiva in periodontal health and disease |
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