Lack of an effect of 6-hydroxydopamine lesions of the nucleus accumbens on intravenous morphine self-administration

The neurotoxin, 6-hydroxydopamine (6-OHDA), has been used to selectively destroy dopamine containing neurons in discrete brain regions. Lesions of the nucleus accumbens with this neurotoxin decrease or eliminate cocaine and amphetamine self-administration and either increase or do not affect opiate...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1988-08, Vol.30 (4), p.1051-1057
Hauptverfasser:	Dworkin, Steven I., Guerin, Glenn F., Co, Conchita, Goeders, Nick E., Smith, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine lesions Analgesics Animals Biogenic Amines - metabolism Biological and medical sciences Brain - drug effects Brain - metabolism Conditioning, Operant - drug effects Dopamine Food reinforcement Hydroxydopamines - pharmacology Intravenous morphine self-administration Male Medical sciences Morphine - administration & dosage Neuropharmacology Neurotoxin lesions Neurotransmitter content Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Nucleus Accumbens - physiopathology Opiate reinforcement Oxidopamine Pharmacology. Drug treatments Rats Rats, Inbred F344 Reinforcement (Psychology) Self Administration Septal Nuclei - physiopathology Water reinforcement
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