Wnt Signaling through the Ror Receptor in the Nervous System
The receptor tyrosine kinase-like orphan receptor (Ror) proteins are conserved tyrosine kinase receptors that play roles in a variety of cellular processes that pattern tissues and organs during vertebrate and invertebrate development. Ror signaling is required for skeleton and neuronal development...
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Veröffentlicht in: | Molecular neurobiology 2014-02, Vol.49 (1), p.303-315 |
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creator | Petrova, Iveta M. Malessy, Martijn J. Verhaagen, Joost Fradkin, Lee G. Noordermeer, Jasprina N. |
description | The receptor tyrosine kinase-like orphan receptor (Ror) proteins are conserved tyrosine kinase receptors that play roles in a variety of cellular processes that pattern tissues and organs during vertebrate and invertebrate development. Ror signaling is required for skeleton and neuronal development and modulates cell migration, cell polarity, and convergent extension.
Ror
has also been implicated in two human skeletal disorders, brachydactyly type B and Robinow syndrome.
Rors
are widely expressed during metazoan development including domains in the nervous system. Here, we review recent progress in understanding the roles of the Ror receptors in neuronal migration, axonal pruning, axon guidance, and synaptic plasticity. The processes by which Ror signaling execute these diverse roles are still largely unknown, but they likely converge on cytoskeletal remodeling. In multiple species, Rors have been shown to act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated in some tissues by the adapter protein disheveled and the non-receptor tyrosine kinase Src. Rors can either activate or repress Wnt target expression depending on the cellular context and can also modulate signal transduction by sequestering Wnt ligands away from their signaling receptors. Future challenges include the identification of signaling components of the Ror pathways and bettering our understanding of the roles of these pleiotropic receptors in patterning the nervous system. |
doi_str_mv | 10.1007/s12035-013-8520-9 |
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Ror
has also been implicated in two human skeletal disorders, brachydactyly type B and Robinow syndrome.
Rors
are widely expressed during metazoan development including domains in the nervous system. Here, we review recent progress in understanding the roles of the Ror receptors in neuronal migration, axonal pruning, axon guidance, and synaptic plasticity. The processes by which Ror signaling execute these diverse roles are still largely unknown, but they likely converge on cytoskeletal remodeling. In multiple species, Rors have been shown to act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated in some tissues by the adapter protein disheveled and the non-receptor tyrosine kinase Src. Rors can either activate or repress Wnt target expression depending on the cellular context and can also modulate signal transduction by sequestering Wnt ligands away from their signaling receptors. Future challenges include the identification of signaling components of the Ror pathways and bettering our understanding of the roles of these pleiotropic receptors in patterning the nervous system.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-013-8520-9</identifier><identifier>PMID: 23990374</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell Movement - physiology ; Humans ; Kinases ; Metazoa ; Nervous system ; Nervous System - cytology ; Nervous System - metabolism ; Neurobiology ; Neurology ; Neurons ; Neurosciences ; Receptor Tyrosine Kinase-like Orphan Receptors - physiology ; Signal Transduction - physiology ; Wnt Signaling Pathway - physiology</subject><ispartof>Molecular neurobiology, 2014-02, Vol.49 (1), p.303-315</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-23107046aa250ede1b63b7d209270ca7d7ccd74c726c3ed54887b65c4c0e22153</citedby><cites>FETCH-LOGICAL-c471t-23107046aa250ede1b63b7d209270ca7d7ccd74c726c3ed54887b65c4c0e22153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-013-8520-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-013-8520-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23990374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrova, Iveta M.</creatorcontrib><creatorcontrib>Malessy, Martijn J.</creatorcontrib><creatorcontrib>Verhaagen, Joost</creatorcontrib><creatorcontrib>Fradkin, Lee G.</creatorcontrib><creatorcontrib>Noordermeer, Jasprina N.</creatorcontrib><title>Wnt Signaling through the Ror Receptor in the Nervous System</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>The receptor tyrosine kinase-like orphan receptor (Ror) proteins are conserved tyrosine kinase receptors that play roles in a variety of cellular processes that pattern tissues and organs during vertebrate and invertebrate development. Ror signaling is required for skeleton and neuronal development and modulates cell migration, cell polarity, and convergent extension.
Ror
has also been implicated in two human skeletal disorders, brachydactyly type B and Robinow syndrome.
Rors
are widely expressed during metazoan development including domains in the nervous system. Here, we review recent progress in understanding the roles of the Ror receptors in neuronal migration, axonal pruning, axon guidance, and synaptic plasticity. The processes by which Ror signaling execute these diverse roles are still largely unknown, but they likely converge on cytoskeletal remodeling. In multiple species, Rors have been shown to act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated in some tissues by the adapter protein disheveled and the non-receptor tyrosine kinase Src. Rors can either activate or repress Wnt target expression depending on the cellular context and can also modulate signal transduction by sequestering Wnt ligands away from their signaling receptors. Future challenges include the identification of signaling components of the Ror pathways and bettering our understanding of the roles of these pleiotropic receptors in patterning the nervous system.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell Movement - physiology</subject><subject>Humans</subject><subject>Kinases</subject><subject>Metazoa</subject><subject>Nervous system</subject><subject>Nervous System - cytology</subject><subject>Nervous System - metabolism</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurosciences</subject><subject>Receptor Tyrosine Kinase-like Orphan Receptors - physiology</subject><subject>Signal Transduction - physiology</subject><subject>Wnt Signaling Pathway - physiology</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1LAzEQhoMotlZ_gBdZ8OIlOkk2mw14keIXFIVW8Rh2s-l2y37UZFfovzftVhFB8DTDzDPvDPMidErgkgCIK0coMI6BMBxzCljuoSHhXGJCYrqPhhBLhkUUxgN05NwSgFIC4hANKJMSmAiH6PqtboNZkddJWdR50C5s0-ULH00wbWwwNdqsWp8U9bb2ZOxH07lgtnatqY7RwTwpnTnZxRF6vbt9GT_gyfP94_hmgnUoSIsp81shjJKEcjCZIWnEUpFRkFSATkQmtM5EqAWNNDMZD-NYpBHXoQbjL-ZshC563ZVt3jvjWlUVTpuyTGrjr1GEA2ccmPwHGkpJmGBMevT8F7psOusfsaUiYDTy6AiRntK2cc6auVrZokrsWhFQGxdU74LyLqiNC2qjfLZT7tLKZN8TX2_3AO0B51t1buyP1X-qfgKcxI8E</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Petrova, Iveta M.</creator><creator>Malessy, Martijn J.</creator><creator>Verhaagen, Joost</creator><creator>Fradkin, Lee G.</creator><creator>Noordermeer, Jasprina N.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140201</creationdate><title>Wnt Signaling through the Ror Receptor in the Nervous System</title><author>Petrova, Iveta M. ; Malessy, Martijn J. ; Verhaagen, Joost ; Fradkin, Lee G. ; Noordermeer, Jasprina N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-23107046aa250ede1b63b7d209270ca7d7ccd74c726c3ed54887b65c4c0e22153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cell Movement - physiology</topic><topic>Humans</topic><topic>Kinases</topic><topic>Metazoa</topic><topic>Nervous system</topic><topic>Nervous System - cytology</topic><topic>Nervous System - metabolism</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurosciences</topic><topic>Receptor Tyrosine Kinase-like Orphan Receptors - physiology</topic><topic>Signal Transduction - physiology</topic><topic>Wnt Signaling Pathway - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrova, Iveta M.</creatorcontrib><creatorcontrib>Malessy, Martijn J.</creatorcontrib><creatorcontrib>Verhaagen, Joost</creatorcontrib><creatorcontrib>Fradkin, Lee G.</creatorcontrib><creatorcontrib>Noordermeer, Jasprina N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrova, Iveta M.</au><au>Malessy, Martijn J.</au><au>Verhaagen, Joost</au><au>Fradkin, Lee G.</au><au>Noordermeer, Jasprina N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wnt Signaling through the Ror Receptor in the Nervous System</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>49</volume><issue>1</issue><spage>303</spage><epage>315</epage><pages>303-315</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>The receptor tyrosine kinase-like orphan receptor (Ror) proteins are conserved tyrosine kinase receptors that play roles in a variety of cellular processes that pattern tissues and organs during vertebrate and invertebrate development. Ror signaling is required for skeleton and neuronal development and modulates cell migration, cell polarity, and convergent extension.
Ror
has also been implicated in two human skeletal disorders, brachydactyly type B and Robinow syndrome.
Rors
are widely expressed during metazoan development including domains in the nervous system. Here, we review recent progress in understanding the roles of the Ror receptors in neuronal migration, axonal pruning, axon guidance, and synaptic plasticity. The processes by which Ror signaling execute these diverse roles are still largely unknown, but they likely converge on cytoskeletal remodeling. In multiple species, Rors have been shown to act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated in some tissues by the adapter protein disheveled and the non-receptor tyrosine kinase Src. Rors can either activate or repress Wnt target expression depending on the cellular context and can also modulate signal transduction by sequestering Wnt ligands away from their signaling receptors. Future challenges include the identification of signaling components of the Ror pathways and bettering our understanding of the roles of these pleiotropic receptors in patterning the nervous system.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23990374</pmid><doi>10.1007/s12035-013-8520-9</doi><tpages>13</tpages></addata></record> |
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subjects | Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Movement - physiology Humans Kinases Metazoa Nervous system Nervous System - cytology Nervous System - metabolism Neurobiology Neurology Neurons Neurosciences Receptor Tyrosine Kinase-like Orphan Receptors - physiology Signal Transduction - physiology Wnt Signaling Pathway - physiology |
title | Wnt Signaling through the Ror Receptor in the Nervous System |
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