Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis
Our investigation explores the immuno-efficiency of sulphated polysaccharides enriched Porphyra vietnamenis. Isolated polysaccharide fraction (17.1–25.8%) was characterized by FTIR and NMR spectroscopy which showed the presence of typical linear backbone structure called as porphyran. Oral administr...
Gespeichert in:
| Veröffentlicht in: | International journal of biological macromolecules 2013-06, Vol.57, p.50-56 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 56 |
|---|---|
| container_issue | |
| container_start_page | 50 |
| container_title | International journal of biological macromolecules |
| container_volume | 57 |
| creator | Bhatia, Saurabh Rathee, Permender Sharma, Kiran Chaugule, B.B. Kar, Nabanita Bera, Tanmoy |
| description | Our investigation explores the immuno-efficiency of sulphated polysaccharides enriched Porphyra vietnamenis. Isolated polysaccharide fraction (17.1–25.8%) was characterized by FTIR and NMR spectroscopy which showed the presence of typical linear backbone structure called as porphyran. Oral administration of porphyran (200–500mg/kg) evoked a significant (P≤0.05) increase in weight of the thymus, spleen and lymphoid organ cellularity. The total leucocyte and lymphocyte count was increased significantly (P |
| doi_str_mv | 10.1016/j.ijbiomac.2013.03.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1505350192</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0141813013000950</els_id><sourcerecordid>1345512627</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-299707b8c7b29c3b6548f1276e325c3beee02bc945abb995c3872d0c400507ae3</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhi0EotvCK5QcyyHLjB0n8Q1UAa1UCSToiYPlOBPWqzgOdoK0b49Xu-VaaaTRjL6Zsf-fsWuELQLWH_Zbt-9c8MZuOaDYQg7kL9gG20aVACBesg1ghWWLAi7YZUr73K0ltq_ZBRcSoBK4Yb_uvV-nUPrQr6NZXJgKGgaySxGGIq3jvDML9cUcxkMy1u5MdD0VN3OI8-4QzfS-GGLwxfdzXfx1tEzG05RcesNeDWZM9Pacr9jjl88_b-_Kh29f728_PZS24nIpuVINNF1rm44rK7paVu2AvKlJcJlrIgLeWVVJ03VK5Vbb8B5sBSChMSSu2M1p7xzDn5XSor1LlsbRTBTWpFGCzB9GxZ9HRSUl8po3Ga1PqI0hpUiDnqPzJh40gj56oPf6yQN99EBDDjzeuD7fWDtP_f-xJ9Ez8O4EDCZo8zu6pB9_5A11NkgqXkEmPp4IyrJlSaNO1tFkqXcxe6P74J57xT9BaaSX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1345512627</pqid></control><display><type>article</type><title>Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Bhatia, Saurabh ; Rathee, Permender ; Sharma, Kiran ; Chaugule, B.B. ; Kar, Nabanita ; Bera, Tanmoy</creator><creatorcontrib>Bhatia, Saurabh ; Rathee, Permender ; Sharma, Kiran ; Chaugule, B.B. ; Kar, Nabanita ; Bera, Tanmoy</creatorcontrib><description>Our investigation explores the immuno-efficiency of sulphated polysaccharides enriched Porphyra vietnamenis. Isolated polysaccharide fraction (17.1–25.8%) was characterized by FTIR and NMR spectroscopy which showed the presence of typical linear backbone structure called as porphyran. Oral administration of porphyran (200–500mg/kg) evoked a significant (P≤0.05) increase in weight of the thymus, spleen and lymphoid organ cellularity. The total leucocyte and lymphocyte count was increased significantly (P<0.005). The increase in the percent neutrophil adhesion to nylon fibres as well as a dose-dependent increase in antibody titre values was observed. A decreased response to DTH reaction induced by SRBC was recorded. A potential phagocytic response was seen and significant changes were observed in the formation of formazone crystals. It also prevented myelosuppression in cyclophosphamide drug treated rats. The results indicated that P. vietnamenis possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2013.03.012</identifier><identifier>PMID: 23500431</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>adhesion ; Administration, Oral ; Algae ; Animals ; antibodies ; Antibody Formation - drug effects ; Antibody Formation - immunology ; autoimmune diseases ; Autoimmune Diseases - drug therapy ; Autoimmune Diseases - immunology ; Autoimmune Diseases - metabolism ; Cell Adhesion - drug effects ; Cell Adhesion - immunology ; crystals ; cyclophosphamide ; dose response ; Fourier transform infrared spectroscopy ; Immunologic Factors - chemistry ; Immunologic Factors - pharmacology ; immunomodulation ; Immunomodulatory ; Lymphocyte Count ; Mice ; neutrophils ; Neutrophils - immunology ; Neutrophils - metabolism ; nuclear magnetic resonance spectroscopy ; nylon ; oral administration ; Polysaccharides ; Porphyra ; Porphyra - chemistry ; Porphyra vietnamensis ; Porphyran ; Rats ; Rats, Wistar ; Sepharose - analogs & derivatives ; Sepharose - chemistry ; Sepharose - pharmacology ; spleen ; thymus gland</subject><ispartof>International journal of biological macromolecules, 2013-06, Vol.57, p.50-56</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-299707b8c7b29c3b6548f1276e325c3beee02bc945abb995c3872d0c400507ae3</citedby><cites>FETCH-LOGICAL-c425t-299707b8c7b29c3b6548f1276e325c3beee02bc945abb995c3872d0c400507ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2013.03.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23500431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhatia, Saurabh</creatorcontrib><creatorcontrib>Rathee, Permender</creatorcontrib><creatorcontrib>Sharma, Kiran</creatorcontrib><creatorcontrib>Chaugule, B.B.</creatorcontrib><creatorcontrib>Kar, Nabanita</creatorcontrib><creatorcontrib>Bera, Tanmoy</creatorcontrib><title>Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Our investigation explores the immuno-efficiency of sulphated polysaccharides enriched Porphyra vietnamenis. Isolated polysaccharide fraction (17.1–25.8%) was characterized by FTIR and NMR spectroscopy which showed the presence of typical linear backbone structure called as porphyran. Oral administration of porphyran (200–500mg/kg) evoked a significant (P≤0.05) increase in weight of the thymus, spleen and lymphoid organ cellularity. The total leucocyte and lymphocyte count was increased significantly (P<0.005). The increase in the percent neutrophil adhesion to nylon fibres as well as a dose-dependent increase in antibody titre values was observed. A decreased response to DTH reaction induced by SRBC was recorded. A potential phagocytic response was seen and significant changes were observed in the formation of formazone crystals. It also prevented myelosuppression in cyclophosphamide drug treated rats. The results indicated that P. vietnamenis possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases.</description><subject>adhesion</subject><subject>Administration, Oral</subject><subject>Algae</subject><subject>Animals</subject><subject>antibodies</subject><subject>Antibody Formation - drug effects</subject><subject>Antibody Formation - immunology</subject><subject>autoimmune diseases</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - metabolism</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Adhesion - immunology</subject><subject>crystals</subject><subject>cyclophosphamide</subject><subject>dose response</subject><subject>Fourier transform infrared spectroscopy</subject><subject>Immunologic Factors - chemistry</subject><subject>Immunologic Factors - pharmacology</subject><subject>immunomodulation</subject><subject>Immunomodulatory</subject><subject>Lymphocyte Count</subject><subject>Mice</subject><subject>neutrophils</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>nylon</subject><subject>oral administration</subject><subject>Polysaccharides</subject><subject>Porphyra</subject><subject>Porphyra - chemistry</subject><subject>Porphyra vietnamensis</subject><subject>Porphyran</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sepharose - analogs & derivatives</subject><subject>Sepharose - chemistry</subject><subject>Sepharose - pharmacology</subject><subject>spleen</subject><subject>thymus gland</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EotvCK5QcyyHLjB0n8Q1UAa1UCSToiYPlOBPWqzgOdoK0b49Xu-VaaaTRjL6Zsf-fsWuELQLWH_Zbt-9c8MZuOaDYQg7kL9gG20aVACBesg1ghWWLAi7YZUr73K0ltq_ZBRcSoBK4Yb_uvV-nUPrQr6NZXJgKGgaySxGGIq3jvDML9cUcxkMy1u5MdD0VN3OI8-4QzfS-GGLwxfdzXfx1tEzG05RcesNeDWZM9Pacr9jjl88_b-_Kh29f728_PZS24nIpuVINNF1rm44rK7paVu2AvKlJcJlrIgLeWVVJ03VK5Vbb8B5sBSChMSSu2M1p7xzDn5XSor1LlsbRTBTWpFGCzB9GxZ9HRSUl8po3Ga1PqI0hpUiDnqPzJh40gj56oPf6yQN99EBDDjzeuD7fWDtP_f-xJ9Ez8O4EDCZo8zu6pB9_5A11NkgqXkEmPp4IyrJlSaNO1tFkqXcxe6P74J57xT9BaaSX</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Bhatia, Saurabh</creator><creator>Rathee, Permender</creator><creator>Sharma, Kiran</creator><creator>Chaugule, B.B.</creator><creator>Kar, Nabanita</creator><creator>Bera, Tanmoy</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>M7N</scope></search><sort><creationdate>20130601</creationdate><title>Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis</title><author>Bhatia, Saurabh ; Rathee, Permender ; Sharma, Kiran ; Chaugule, B.B. ; Kar, Nabanita ; Bera, Tanmoy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-299707b8c7b29c3b6548f1276e325c3beee02bc945abb995c3872d0c400507ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>adhesion</topic><topic>Administration, Oral</topic><topic>Algae</topic><topic>Animals</topic><topic>antibodies</topic><topic>Antibody Formation - drug effects</topic><topic>Antibody Formation - immunology</topic><topic>autoimmune diseases</topic><topic>Autoimmune Diseases - drug therapy</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Adhesion - immunology</topic><topic>crystals</topic><topic>cyclophosphamide</topic><topic>dose response</topic><topic>Fourier transform infrared spectroscopy</topic><topic>Immunologic Factors - chemistry</topic><topic>Immunologic Factors - pharmacology</topic><topic>immunomodulation</topic><topic>Immunomodulatory</topic><topic>Lymphocyte Count</topic><topic>Mice</topic><topic>neutrophils</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - metabolism</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>nylon</topic><topic>oral administration</topic><topic>Polysaccharides</topic><topic>Porphyra</topic><topic>Porphyra - chemistry</topic><topic>Porphyra vietnamensis</topic><topic>Porphyran</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sepharose - analogs & derivatives</topic><topic>Sepharose - chemistry</topic><topic>Sepharose - pharmacology</topic><topic>spleen</topic><topic>thymus gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhatia, Saurabh</creatorcontrib><creatorcontrib>Rathee, Permender</creatorcontrib><creatorcontrib>Sharma, Kiran</creatorcontrib><creatorcontrib>Chaugule, B.B.</creatorcontrib><creatorcontrib>Kar, Nabanita</creatorcontrib><creatorcontrib>Bera, Tanmoy</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhatia, Saurabh</au><au>Rathee, Permender</au><au>Sharma, Kiran</au><au>Chaugule, B.B.</au><au>Kar, Nabanita</au><au>Bera, Tanmoy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>57</volume><spage>50</spage><epage>56</epage><pages>50-56</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Our investigation explores the immuno-efficiency of sulphated polysaccharides enriched Porphyra vietnamenis. Isolated polysaccharide fraction (17.1–25.8%) was characterized by FTIR and NMR spectroscopy which showed the presence of typical linear backbone structure called as porphyran. Oral administration of porphyran (200–500mg/kg) evoked a significant (P≤0.05) increase in weight of the thymus, spleen and lymphoid organ cellularity. The total leucocyte and lymphocyte count was increased significantly (P<0.005). The increase in the percent neutrophil adhesion to nylon fibres as well as a dose-dependent increase in antibody titre values was observed. A decreased response to DTH reaction induced by SRBC was recorded. A potential phagocytic response was seen and significant changes were observed in the formation of formazone crystals. It also prevented myelosuppression in cyclophosphamide drug treated rats. The results indicated that P. vietnamenis possesses potential immunomodulatory activity and has therapeutic potential for the prevention of autoimmune diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23500431</pmid><doi>10.1016/j.ijbiomac.2013.03.012</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0141-8130 |
| ispartof | International journal of biological macromolecules, 2013-06, Vol.57, p.50-56 |
| issn | 0141-8130 1879-0003 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1505350192 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | adhesion Administration, Oral Algae Animals antibodies Antibody Formation - drug effects Antibody Formation - immunology autoimmune diseases Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Cell Adhesion - drug effects Cell Adhesion - immunology crystals cyclophosphamide dose response Fourier transform infrared spectroscopy Immunologic Factors - chemistry Immunologic Factors - pharmacology immunomodulation Immunomodulatory Lymphocyte Count Mice neutrophils Neutrophils - immunology Neutrophils - metabolism nuclear magnetic resonance spectroscopy nylon oral administration Polysaccharides Porphyra Porphyra - chemistry Porphyra vietnamensis Porphyran Rats Rats, Wistar Sepharose - analogs & derivatives Sepharose - chemistry Sepharose - pharmacology spleen thymus gland |
| title | Immuno-modulation effect of sulphated polysaccharide (porphyran) from Porphyra vietnamensis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T11%3A33%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immuno-modulation%20effect%20of%20sulphated%20polysaccharide%20(porphyran)%20from%20Porphyra%20vietnamensis&rft.jtitle=International%20journal%20of%20biological%20macromolecules&rft.au=Bhatia,%20Saurabh&rft.date=2013-06-01&rft.volume=57&rft.spage=50&rft.epage=56&rft.pages=50-56&rft.issn=0141-8130&rft.eissn=1879-0003&rft_id=info:doi/10.1016/j.ijbiomac.2013.03.012&rft_dat=%3Cproquest_cross%3E1345512627%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1345512627&rft_id=info:pmid/23500431&rft_els_id=S0141813013000950&rfr_iscdi=true |