Antifungal properties of the anti-hypertensive drug: Aliskiren
Abstract Objectives Aliskiren, the first in a new class of orally active renin inhibitors, is licensed for the treatment of hypertension. It inhibits plasma renin activity directly, thereby reducing generation of angiotensin II. In this study, we have explored the anti- Candida properties of aliskir...
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| Veröffentlicht in: | Archives of oral biology 2013-09, Vol.58 (9), p.1109-1115 |
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| creator | Kathwate, Gunderao Hanumantrao Karuppayil, S. Mohan |
| description | Abstract Objectives Aliskiren, the first in a new class of orally active renin inhibitors, is licensed for the treatment of hypertension. It inhibits plasma renin activity directly, thereby reducing generation of angiotensin II. In this study, we have explored the anti- Candida properties of aliskiren. Methods Candida albicans was cultured in the presence or absence of aliskiren for various time periods. Subsequently, inhibition of growth, germtube formation, adhesion, early/matured biofilm development and secreted aspartic protease (SAP) activity were studied. Results When cultured in the presence of aliskiren, Candida showed significant reduction in the activity of aspartic proteases. Aliskiren impaired in vitro growth of C. albicans . It also affected two other virulence factors, germtube and adhesion. There is reduction in early and matured biofilm when treated with aliskiren. Conclusions Aliskiren could be considered as a candidate for antifungal drug development. |
| doi_str_mv | 10.1016/j.archoralbio.2013.02.006 |
| format | Article |
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Mohan</creator><creatorcontrib>Kathwate, Gunderao Hanumantrao ; Karuppayil, S. Mohan</creatorcontrib><description>Abstract Objectives Aliskiren, the first in a new class of orally active renin inhibitors, is licensed for the treatment of hypertension. It inhibits plasma renin activity directly, thereby reducing generation of angiotensin II. In this study, we have explored the anti- Candida properties of aliskiren. Methods Candida albicans was cultured in the presence or absence of aliskiren for various time periods. Subsequently, inhibition of growth, germtube formation, adhesion, early/matured biofilm development and secreted aspartic protease (SAP) activity were studied. Results When cultured in the presence of aliskiren, Candida showed significant reduction in the activity of aspartic proteases. Aliskiren impaired in vitro growth of C. albicans . It also affected two other virulence factors, germtube and adhesion. There is reduction in early and matured biofilm when treated with aliskiren. Conclusions Aliskiren could be considered as a candidate for antifungal drug development.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2013.02.006</identifier><identifier>PMID: 23722042</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Aliskiren ; Amides - chemistry ; Amides - pharmacology ; Antifungal Agents - pharmacology ; Antihypertensive Agents - pharmacology ; Aspartic Acid Proteases - secretion ; Biofilms - drug effects ; Candida albicans ; Candida albicans - drug effects ; Candida albicans - enzymology ; Candida albicans - growth & development ; Cell Culture Techniques ; Dentistry ; Drug Repositioning ; Fumarates - chemistry ; Fumarates - pharmacology ; HIV protease inhibitors ; Microscopy, Electron, Scanning ; Renin - antagonists & inhibitors ; Secreted aspartic proteases</subject><ispartof>Archives of oral biology, 2013-09, Vol.58 (9), p.1109-1115</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-d2f8c6d9dc5a227d38bec5789a0d71b0e98bd2deeefa966578dc55b04327c79f3</citedby><cites>FETCH-LOGICAL-c465t-d2f8c6d9dc5a227d38bec5789a0d71b0e98bd2deeefa966578dc55b04327c79f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2013.02.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23722042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kathwate, Gunderao Hanumantrao</creatorcontrib><creatorcontrib>Karuppayil, S. Mohan</creatorcontrib><title>Antifungal properties of the anti-hypertensive drug: Aliskiren</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Abstract Objectives Aliskiren, the first in a new class of orally active renin inhibitors, is licensed for the treatment of hypertension. It inhibits plasma renin activity directly, thereby reducing generation of angiotensin II. In this study, we have explored the anti- Candida properties of aliskiren. Methods Candida albicans was cultured in the presence or absence of aliskiren for various time periods. Subsequently, inhibition of growth, germtube formation, adhesion, early/matured biofilm development and secreted aspartic protease (SAP) activity were studied. Results When cultured in the presence of aliskiren, Candida showed significant reduction in the activity of aspartic proteases. Aliskiren impaired in vitro growth of C. albicans . It also affected two other virulence factors, germtube and adhesion. There is reduction in early and matured biofilm when treated with aliskiren. Conclusions Aliskiren could be considered as a candidate for antifungal drug development.</description><subject>Advanced Basic Science</subject><subject>Aliskiren</subject><subject>Amides - chemistry</subject><subject>Amides - pharmacology</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Aspartic Acid Proteases - secretion</subject><subject>Biofilms - drug effects</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - enzymology</subject><subject>Candida albicans - growth & development</subject><subject>Cell Culture Techniques</subject><subject>Dentistry</subject><subject>Drug Repositioning</subject><subject>Fumarates - chemistry</subject><subject>Fumarates - pharmacology</subject><subject>HIV protease inhibitors</subject><subject>Microscopy, Electron, Scanning</subject><subject>Renin - antagonists & inhibitors</subject><subject>Secreted aspartic proteases</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1PxCAQhonRuOvHXzD15qUVaKHFg8lm41di4kE9EwpTl263XaHdZP-9NKvGeNETMPO-M8MzCJ0TnBBM-GWdKKcXnVNNabuEYpImmCYY8z00JUUuYsIw30dTjHEaC8HFBB15X4cn45wcoglNc0pxRqfoetb2thraN9VEa9etwfUWfNRVUb-ASIVkvNiOUWi93UBk3PB2Fc0a65fWQXuCDirVeDj9PI_R6-3Ny_w-fny6e5jPHmOdcdbHhlaF5kYYzRSluUmLEjTLC6GwyUmJQRSloQYAKiU4D5mgZCXOUprrXFTpMbrY1Q0zvg_ge7myXkPTqBa6wcvwYZZmgtHib2lGGBNFwUep2Em167x3UMm1syvltpJgOZKWtfxBWo6kJaYykA7es882Q7kC8-38QhsE850AApeNBSe9ttBqMAGc7qXp7L_aXP-qohvbWq2aJWzB193g2gBeEumDQT6PKx83TtJw42GMD4Ezqjc</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Kathwate, Gunderao Hanumantrao</creator><creator>Karuppayil, S. 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Mohan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-d2f8c6d9dc5a227d38bec5789a0d71b0e98bd2deeefa966578dc55b04327c79f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Advanced Basic Science</topic><topic>Aliskiren</topic><topic>Amides - chemistry</topic><topic>Amides - pharmacology</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Aspartic Acid Proteases - secretion</topic><topic>Biofilms - drug effects</topic><topic>Candida albicans</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - enzymology</topic><topic>Candida albicans - growth & development</topic><topic>Cell Culture Techniques</topic><topic>Dentistry</topic><topic>Drug Repositioning</topic><topic>Fumarates - chemistry</topic><topic>Fumarates - pharmacology</topic><topic>HIV protease inhibitors</topic><topic>Microscopy, Electron, Scanning</topic><topic>Renin - antagonists & inhibitors</topic><topic>Secreted aspartic proteases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kathwate, Gunderao Hanumantrao</creatorcontrib><creatorcontrib>Karuppayil, S. Mohan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kathwate, Gunderao Hanumantrao</au><au>Karuppayil, S. Mohan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antifungal properties of the anti-hypertensive drug: Aliskiren</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>58</volume><issue>9</issue><spage>1109</spage><epage>1115</epage><pages>1109-1115</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Abstract Objectives Aliskiren, the first in a new class of orally active renin inhibitors, is licensed for the treatment of hypertension. It inhibits plasma renin activity directly, thereby reducing generation of angiotensin II. In this study, we have explored the anti- Candida properties of aliskiren. Methods Candida albicans was cultured in the presence or absence of aliskiren for various time periods. Subsequently, inhibition of growth, germtube formation, adhesion, early/matured biofilm development and secreted aspartic protease (SAP) activity were studied. Results When cultured in the presence of aliskiren, Candida showed significant reduction in the activity of aspartic proteases. Aliskiren impaired in vitro growth of C. albicans . It also affected two other virulence factors, germtube and adhesion. There is reduction in early and matured biofilm when treated with aliskiren. Conclusions Aliskiren could be considered as a candidate for antifungal drug development.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23722042</pmid><doi>10.1016/j.archoralbio.2013.02.006</doi><tpages>7</tpages></addata></record> |
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| subjects | Advanced Basic Science Aliskiren Amides - chemistry Amides - pharmacology Antifungal Agents - pharmacology Antihypertensive Agents - pharmacology Aspartic Acid Proteases - secretion Biofilms - drug effects Candida albicans Candida albicans - drug effects Candida albicans - enzymology Candida albicans - growth & development Cell Culture Techniques Dentistry Drug Repositioning Fumarates - chemistry Fumarates - pharmacology HIV protease inhibitors Microscopy, Electron, Scanning Renin - antagonists & inhibitors Secreted aspartic proteases |
| title | Antifungal properties of the anti-hypertensive drug: Aliskiren |
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