Effects of sodium tanshinone IIA sulfonate against Marek's disease virus in experimentally infected chickens
Chickens experimentally infected with Marek's disease virus J-1 strain were used to evaluate the anti-Marek's disease virus (MDV) activity of sodium tanshinone IIA sulfonate (STS) in vivo. Chickens in same group were kept in one pen and control group chickens were housed in negative pressu...
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| Veröffentlicht in: | International journal of biological macromolecules 2013-07, Vol.58, p.258-262 |
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| container_title | International journal of biological macromolecules |
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| creator | Zhang, Jin-qiang Gu, Yao-liang Wu, Cai-hong Ma, Hai-li He, Jun-ping Bai, Yuan-sheng Li, Hong-quan |
| description | Chickens experimentally infected with Marek's disease virus J-1 strain were used to evaluate the anti-Marek's disease virus (MDV) activity of sodium tanshinone IIA sulfonate (STS) in vivo. Chickens in same group were kept in one pen and control group chickens were housed in negative pressure isolator. Chickens were treated with different dose of STS or ABOB for 21 consecutive days. Peripheral T lymphocyte proliferation, expression level of IFN-γ and IL-10 in serum, and MDV load in spleen were determined. The results showed that the treatments with STS and ABOB could significantly increase stimulating index (SI) of peripheral T lymphocytes while the SI is dropping due to the MDV infection, SI of chickens in STS prevention groups were significantly higher than that in STS treatment group and ABOB group (P |
| doi_str_mv | 10.1016/j.ijbiomac.2013.04.029 |
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Chickens in same group were kept in one pen and control group chickens were housed in negative pressure isolator. Chickens were treated with different dose of STS or ABOB for 21 consecutive days. Peripheral T lymphocyte proliferation, expression level of IFN-γ and IL-10 in serum, and MDV load in spleen were determined. The results showed that the treatments with STS and ABOB could significantly increase stimulating index (SI) of peripheral T lymphocytes while the SI is dropping due to the MDV infection, SI of chickens in STS prevention groups were significantly higher than that in STS treatment group and ABOB group (P<0.05 or P<0.01); IFN-γ and IL-10 level of chickens in STS groups were higher than that in other groups (P<0.05 or P<0.01). The results of qPCR demonstrated that STS could inhibit the virus replication in spleen of chickens infected with MDV. These findings indicated that STS can be potentially applied as an anti-MDV drug and set a solid basis for further investigating the antiviral mechanisms of STS.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2013.04.029</identifier><identifier>PMID: 23603081</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antiviral Agents - pharmacology ; Antiviral Agents - therapeutic use ; Avian Proteins - blood ; blood serum ; Cell Proliferation - drug effects ; Chickens ; Drug Evaluation, Preclinical ; drugs ; IFN-γ ; IL-10 ; In vivo ; interferon-gamma ; Interferon-gamma - blood ; interleukin-10 ; Interleukin-10 - blood ; lymphocyte proliferation ; Mardivirus ; Marek Disease - blood ; Marek Disease - drug therapy ; Marek Disease - virology ; Marek's disease herpesvirus ; Marek's disease virus ; Meq ; Phenanthrenes - pharmacology ; Phenanthrenes - therapeutic use ; Poultry Diseases - blood ; Poultry Diseases - drug therapy ; Poultry Diseases - virology ; quantitative polymerase chain reaction ; Sodium tanshinone IIA sulfonate ; spleen ; Spleen - virology ; T-lymphocytes ; T-Lymphocytes - drug effects ; T-Lymphocytes - physiology ; T-Lymphocytes - virology ; Viral Load ; virus replication ; viruses</subject><ispartof>International journal of biological macromolecules, 2013-07, Vol.58, p.258-262</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-3dc3cf843c3c07bdae58f614c1d2fb4a070a9ecfab9a77b19394be8f56df444a3</citedby><cites>FETCH-LOGICAL-c425t-3dc3cf843c3c07bdae58f614c1d2fb4a070a9ecfab9a77b19394be8f56df444a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2013.04.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23603081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jin-qiang</creatorcontrib><creatorcontrib>Gu, Yao-liang</creatorcontrib><creatorcontrib>Wu, Cai-hong</creatorcontrib><creatorcontrib>Ma, Hai-li</creatorcontrib><creatorcontrib>He, Jun-ping</creatorcontrib><creatorcontrib>Bai, Yuan-sheng</creatorcontrib><creatorcontrib>Li, Hong-quan</creatorcontrib><title>Effects of sodium tanshinone IIA sulfonate against Marek's disease virus in experimentally infected chickens</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Chickens experimentally infected with Marek's disease virus J-1 strain were used to evaluate the anti-Marek's disease virus (MDV) activity of sodium tanshinone IIA sulfonate (STS) in vivo. Chickens in same group were kept in one pen and control group chickens were housed in negative pressure isolator. Chickens were treated with different dose of STS or ABOB for 21 consecutive days. Peripheral T lymphocyte proliferation, expression level of IFN-γ and IL-10 in serum, and MDV load in spleen were determined. The results showed that the treatments with STS and ABOB could significantly increase stimulating index (SI) of peripheral T lymphocytes while the SI is dropping due to the MDV infection, SI of chickens in STS prevention groups were significantly higher than that in STS treatment group and ABOB group (P<0.05 or P<0.01); IFN-γ and IL-10 level of chickens in STS groups were higher than that in other groups (P<0.05 or P<0.01). The results of qPCR demonstrated that STS could inhibit the virus replication in spleen of chickens infected with MDV. These findings indicated that STS can be potentially applied as an anti-MDV drug and set a solid basis for further investigating the antiviral mechanisms of STS.</description><subject>Animals</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Avian Proteins - blood</subject><subject>blood serum</subject><subject>Cell Proliferation - drug effects</subject><subject>Chickens</subject><subject>Drug Evaluation, Preclinical</subject><subject>drugs</subject><subject>IFN-γ</subject><subject>IL-10</subject><subject>In vivo</subject><subject>interferon-gamma</subject><subject>Interferon-gamma - blood</subject><subject>interleukin-10</subject><subject>Interleukin-10 - blood</subject><subject>lymphocyte proliferation</subject><subject>Mardivirus</subject><subject>Marek Disease - blood</subject><subject>Marek Disease - drug therapy</subject><subject>Marek Disease - virology</subject><subject>Marek's disease herpesvirus</subject><subject>Marek's disease virus</subject><subject>Meq</subject><subject>Phenanthrenes - pharmacology</subject><subject>Phenanthrenes - therapeutic use</subject><subject>Poultry Diseases - blood</subject><subject>Poultry Diseases - drug therapy</subject><subject>Poultry Diseases - virology</subject><subject>quantitative polymerase chain reaction</subject><subject>Sodium tanshinone IIA sulfonate</subject><subject>spleen</subject><subject>Spleen - virology</subject><subject>T-lymphocytes</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - physiology</subject><subject>T-Lymphocytes - virology</subject><subject>Viral Load</subject><subject>virus replication</subject><subject>viruses</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhLxTf4JIwjp2vG1VVYKUiDtCz5djj1tskXjxJ1f57vNqWa08jjZ557ZmHsTMBpQDRfNmVYTeEOBlbViBkCaqEqn_FNqJr-wIA5Gu2AaFE0QkJJ-wd0S53m1p0b9lJJRuQ0IkNGy-9R7sQj55TdGGd-GJmug1znJFvt-ec1tHH2SzIzY0JMy38p0l494m4C4SGkN-HtBIPM8eHPaYw4byYcXzMnUM0Om5vg73Dmd6zN96MhB-e6im7_nb55-JHcfXr-_bi_KqwqqqXQjorre-UzAXawRmsO98IZYWr_KAMtGB6tN4MvWnbQfSyVwN2vm6cV0oZeco-H3P3Kf5dkRY9BbI4jmbGuJIWNdRS9apuX0Zlo1roFaiMNkfUpkiU0Ot9XtakRy1AH6TonX6Wog9SNCidpeTBs6c31mFC93_s2UIGPh4Bb6I2NymQvv6dE5psrO6rts7E1yOB-Wz3AZMmG3C26ELKN9Yuhpd-8Q_dV6vU</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Zhang, Jin-qiang</creator><creator>Gu, Yao-liang</creator><creator>Wu, Cai-hong</creator><creator>Ma, Hai-li</creator><creator>He, Jun-ping</creator><creator>Bai, Yuan-sheng</creator><creator>Li, Hong-quan</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20130701</creationdate><title>Effects of sodium tanshinone IIA sulfonate against Marek's disease virus in experimentally infected chickens</title><author>Zhang, Jin-qiang ; Gu, Yao-liang ; Wu, Cai-hong ; Ma, Hai-li ; He, Jun-ping ; Bai, Yuan-sheng ; Li, Hong-quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-3dc3cf843c3c07bdae58f614c1d2fb4a070a9ecfab9a77b19394be8f56df444a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antiviral Agents - pharmacology</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Avian Proteins - blood</topic><topic>blood serum</topic><topic>Cell Proliferation - drug effects</topic><topic>Chickens</topic><topic>Drug Evaluation, Preclinical</topic><topic>drugs</topic><topic>IFN-γ</topic><topic>IL-10</topic><topic>In vivo</topic><topic>interferon-gamma</topic><topic>Interferon-gamma - blood</topic><topic>interleukin-10</topic><topic>Interleukin-10 - blood</topic><topic>lymphocyte proliferation</topic><topic>Mardivirus</topic><topic>Marek Disease - blood</topic><topic>Marek Disease - drug therapy</topic><topic>Marek Disease - virology</topic><topic>Marek's disease herpesvirus</topic><topic>Marek's disease virus</topic><topic>Meq</topic><topic>Phenanthrenes - pharmacology</topic><topic>Phenanthrenes - therapeutic use</topic><topic>Poultry Diseases - blood</topic><topic>Poultry Diseases - drug therapy</topic><topic>Poultry Diseases - virology</topic><topic>quantitative polymerase chain reaction</topic><topic>Sodium tanshinone IIA sulfonate</topic><topic>spleen</topic><topic>Spleen - virology</topic><topic>T-lymphocytes</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - physiology</topic><topic>T-Lymphocytes - virology</topic><topic>Viral Load</topic><topic>virus replication</topic><topic>viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jin-qiang</creatorcontrib><creatorcontrib>Gu, Yao-liang</creatorcontrib><creatorcontrib>Wu, Cai-hong</creatorcontrib><creatorcontrib>Ma, Hai-li</creatorcontrib><creatorcontrib>He, Jun-ping</creatorcontrib><creatorcontrib>Bai, Yuan-sheng</creatorcontrib><creatorcontrib>Li, Hong-quan</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jin-qiang</au><au>Gu, Yao-liang</au><au>Wu, Cai-hong</au><au>Ma, Hai-li</au><au>He, Jun-ping</au><au>Bai, Yuan-sheng</au><au>Li, Hong-quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of sodium tanshinone IIA sulfonate against Marek's disease virus in experimentally infected chickens</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>58</volume><spage>258</spage><epage>262</epage><pages>258-262</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Chickens experimentally infected with Marek's disease virus J-1 strain were used to evaluate the anti-Marek's disease virus (MDV) activity of sodium tanshinone IIA sulfonate (STS) in vivo. Chickens in same group were kept in one pen and control group chickens were housed in negative pressure isolator. Chickens were treated with different dose of STS or ABOB for 21 consecutive days. Peripheral T lymphocyte proliferation, expression level of IFN-γ and IL-10 in serum, and MDV load in spleen were determined. The results showed that the treatments with STS and ABOB could significantly increase stimulating index (SI) of peripheral T lymphocytes while the SI is dropping due to the MDV infection, SI of chickens in STS prevention groups were significantly higher than that in STS treatment group and ABOB group (P<0.05 or P<0.01); IFN-γ and IL-10 level of chickens in STS groups were higher than that in other groups (P<0.05 or P<0.01). The results of qPCR demonstrated that STS could inhibit the virus replication in spleen of chickens infected with MDV. These findings indicated that STS can be potentially applied as an anti-MDV drug and set a solid basis for further investigating the antiviral mechanisms of STS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23603081</pmid><doi>10.1016/j.ijbiomac.2013.04.029</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Avian Proteins - blood blood serum Cell Proliferation - drug effects Chickens Drug Evaluation, Preclinical drugs IFN-γ IL-10 In vivo interferon-gamma Interferon-gamma - blood interleukin-10 Interleukin-10 - blood lymphocyte proliferation Mardivirus Marek Disease - blood Marek Disease - drug therapy Marek Disease - virology Marek's disease herpesvirus Marek's disease virus Meq Phenanthrenes - pharmacology Phenanthrenes - therapeutic use Poultry Diseases - blood Poultry Diseases - drug therapy Poultry Diseases - virology quantitative polymerase chain reaction Sodium tanshinone IIA sulfonate spleen Spleen - virology T-lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - physiology T-Lymphocytes - virology Viral Load virus replication viruses |
| title | Effects of sodium tanshinone IIA sulfonate against Marek's disease virus in experimentally infected chickens |
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