Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines
Highlights • Histopathology can be used as a novel parameter of protection in bovine TB. • Multiple cytokine-producing T-cells relate more to an on-going immune response than to protection in bovine TB. • Ad5-85A is a promising BCG-boosting vaccine candidate against tuberculosis in cattle.
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Veröffentlicht in: | Vaccine 2014-03, Vol.32 (11), p.1304-1310 |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Highlights • Histopathology can be used as a novel parameter of protection in bovine TB. • Multiple cytokine-producing T-cells relate more to an on-going immune response than to protection in bovine TB. • Ad5-85A is a promising BCG-boosting vaccine candidate against tuberculosis in cattle. |
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ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2013.11.045 |