Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines

Highlights • Histopathology can be used as a novel parameter of protection in bovine TB. • Multiple cytokine-producing T-cells relate more to an on-going immune response than to protection in bovine TB. • Ad5-85A is a promising BCG-boosting vaccine candidate against tuberculosis in cattle.

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Veröffentlicht in:Vaccine 2014-03, Vol.32 (11), p.1304-1310
Hauptverfasser: Dean, G, Whelan, A, Clifford, D, Salguero, F.J, Xing, Z, Gilbert, S, McShane, H, Hewinson, R.G, Vordermeier, M, Villarreal-Ramos, B
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Sprache:eng
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Zusammenfassung:Highlights • Histopathology can be used as a novel parameter of protection in bovine TB. • Multiple cytokine-producing T-cells relate more to an on-going immune response than to protection in bovine TB. • Ad5-85A is a promising BCG-boosting vaccine candidate against tuberculosis in cattle.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.11.045