Synthesis and Anti-HIV-1 Activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil Derivatives
1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar amounts of 2,4- bis (trimethylsilyloxy)pyrimidine and 1-halo-ω-(phenoxy)alkane or -alkene in order to discover new non-nucleoside inhibitors of HIV-1 reverse transcriptase. Their anti-HIV-1 activity wa...
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| Veröffentlicht in: | Pharmaceutical chemistry journal 2013-12, Vol.47 (9), p.459-463 |
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| container_title | Pharmaceutical chemistry journal |
| container_volume | 47 |
| creator | Paramonova, M. P. Babkov, D. A. Valuev-Elliston, V. T. Ivanov, A. V. Kochetkov, S. N. Pannecouque, C. Ozerov, A. A. Balzarini, J. Novikov, M. S. |
| description | 1-[ω-(Phenoxy)alkyl and -alkenyl]uracil derivatives were synthesized via condensation of equimolar amounts of 2,4-
bis
(trimethylsilyloxy)pyrimidine and 1-halo-ω-(phenoxy)alkane or -alkene in order to discover new non-nucleoside inhibitors of HIV-1 reverse transcriptase. Their anti-HIV-1 activity was studied in CEM-cell culture and against HIV-1 reverse transcriptase. It was found that several compounds exhibited marked activity. |
| doi_str_mv | 10.1007/s11094-013-0980-8 |
| format | Article |
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bis
(trimethylsilyloxy)pyrimidine and 1-halo-ω-(phenoxy)alkane or -alkene in order to discover new non-nucleoside inhibitors of HIV-1 reverse transcriptase. Their anti-HIV-1 activity was studied in CEM-cell culture and against HIV-1 reverse transcriptase. It was found that several compounds exhibited marked activity.</abstract><cop>Boston</cop><pub>Springer US</pub><doi>10.1007/s11094-013-0980-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pharmaceutical chemistry journal, 2013-12, Vol.47 (9), p.459-463 |
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| language | eng |
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| subjects | Antiviral agents DNA polymerases Highly active antiretroviral therapy HIV (Viruses) Human immunodeficiency virus 1 Medicine Olefins Organic Chemistry Pharmacology/Toxicology Pharmacy Pyrimidines Search for New Drugs |
| title | Synthesis and Anti-HIV-1 Activity of 1-[ω-(Phenoxy)Alkyl and -Alkenyl]Uracil Derivatives |
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