A Naturally Occurring Vif Mutant (I107T) Attenuates Anti-APOBEC3G Activity and HIV-1 Replication

The human immunodeficiency virus type 1 (HIV-1) Vif protein counteracts the antiviral activity of the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of proteins by targeting the proteins for degradation through the ubiquitin–proteasome pathway. Previous mutagenic...

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Veröffentlicht in:	Journal of molecular biology 2013-08, Vol.425 (16), p.2840-2852
Hauptverfasser:	Peng, Jinyu, Ao, Zhujun, Matthews, Chris, Wang, Xiaoxia, Ramdahin, Sue, Chen, Xi, Li, Junhua, Chen, Liyu, He, Jianmei, Ball, Blake, Fowke, Keith, Plummer, Frank, Embree, Joanne, Yao, Xiaojian
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids antiviral properties APOBEC-3G Deaminase APOBEC3G apolipoprotein B Cytidine Deaminase - antagonists & inhibitors genes Genetic Variation HIV Infections - immunology HIV Infections - virology HIV Long-Term Survivors HIV-1 HIV-1 - genetics HIV-1 - immunology HIV-1 - isolation & purification HIV-1 - pathogenicity HIV-1 - physiology HIV-1 replication Human immunodeficiency virus 1 Humans Kenya long-term survivors messenger RNA mutagenesis mutagenicity Mutant Proteins - genetics Mutant Proteins - metabolism mutants Mutation, Missense nucleotide sequences proteasome endopeptidase complex Proteolysis sequence analysis T-lymphocytes Vif vif Gene Products, Human Immunodeficiency Virus - genetics vif Gene Products, Human Immunodeficiency Virus - metabolism Virus Replication viruses
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