Links between DNA-repair gene polymorphisms and chromosomal aberrations in lung-cancer patients

This work presents the results of research into the links between DNA-repair gene polymorphisms and chromosomal aberrations in lung-cancer patients. Significant positive links have been found between lung cancer and the hOGG1 G/G and XPD G/G genotypes. A significant negative association has been found between the hOGG1 C/C genotypes and lung cancer. It has been shown that metaphases with chromosomal aberrations were significantly more frequent in lung-cancer patients than in the control group. Levels of chromosomal aberrations in the carriers of all APE1 and XPD genotypes, XRCC1 G/G genotype, ADPRT T/T genotype, and hOGG1 C/C genotypes reliably differed between the study and control groups. Statistically significant differences have been found between the lung-cancer patients carrying the XPD T/T genotype and those with G/G genotype of this gene.