Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons
Summary Computed tomography-based depth-specific image processing is able to precisely identify regional differences between healthy patellae and patellae with osteoarthritis. Introduction This study aims to assess the precision errors and potential differences in regional, depth-specific subchondra...
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| Veröffentlicht in: | Osteoporosis international 2014-03, Vol.25 (3), p.1107-1114 |
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| creator | Burnett, W. D. Kontulainen, S. A. McLennan, C. E. Hunter, D. J. Wilson, D. R. Johnston, J. D. |
| description | Summary
Computed tomography-based depth-specific image processing is able to precisely identify regional differences between healthy patellae and patellae with osteoarthritis.
Introduction
This study aims to assess the precision errors and potential differences in regional, depth-specific subchondral bone mineral density (BMD) in normal and osteoarthritic (OA) human patellae in vivo using CT-based density analyses.
Methods
Fourteen participants (2 men and 12 women; mean age, 51.4; SD, 11.8 years) were scanned using clinical quantitative CT (QCT) three times over 2 days. Participants were categorized as either normal (
n
= 7) or exhibiting radiographic OA (
n
= 7). Average subchondral BMD was assessed at three depths relative to the subchondral surface. Regional BMD analysis included: total lateral facet BMD, total medial facet BMD, and superior/middle/inferior BMD of lateral and medial facets at normalized depths of 0–2.5, 2.5–5, and 5–7.5 mm from the subchondral surface. We assessed precision using root mean square coefficients of variation (CV%). We evaluated differences between OA and normal BMD by (1) calculating percentage differences between the groups (in relation to normal BMD) (2) relating percentage differences to respective CV% errors and (3) determining effect sizes using Cohen’s
d
.
Results
Root mean square CV% precision errors ranged from 1.1 to 5.9 %. Percentage differences between OA and normal BMD varied from −1.6 to −30.1 % (BMD lower in OA patellae). In relation to precision errors, percentage differences were, on average, 5.5× greater than CV% errors. Cohen’s
d
effect sizes ranged from −1.7 to −0.1. Largest differences were noted at depths of 2.5–5 and 5–7.5 mm from the subchondral surface.
Conclusions
Patellar subchondral BMD measures were precise (average CV%, ≤3 %). This region- and depth-specific CT-based imaging tool characterized regional standardized BMD differences between normal and OA patellae in vivo. |
| doi_str_mv | 10.1007/s00198-013-2568-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1505344400</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1499140607</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-7f96781f8febbdfa50c5967331333902325952baeeef65587f37c986e2de3fa33</originalsourceid><addsrcrecordid>eNqFkd9q1UAQxhdR7Gn1AbyRgDfeRPdvNuudFLVCQRAF78Imme3ZkuzGnaTQl_CZndNTRQTxapmd3_fNMB9jzwR_JTi3r5Fz4dqaC1VL07S1fMB2QiuqXGMesh13ytZOi28n7BTxmpPGOfuYnUgtpdBG7tiPz3AVc_JTNcKy7mtcYIghDhVu_bDPaSzU6nMC6ieM6201g8etAFYxVRlXyL6s-xJX0vg0VimXmSSLX2GaPLw5YDfxJldLIWekWXcYVVOcY_LlthryvPgSMSd8wh4FPyE8vX_P2Nf3776cX9SXnz58PH97WQ-am7W2wTW2FaEN0Pdj8IYPhn6UEkopx6WSxhnZewAIjTGtDcoOrm1AjqCCV-qMvTz6LiV_3wDXbo44HDZOkDfshOFGaa05_z-qnROaN9wS-uIv9DpvhY57R1llKClHlDhSQ8mIBUK3lDjTITrBu0Ou3THXjujukGsnSfP83nnrZxh_K34FSYA8AkitdAXlj9H_dP0JvS-v6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1497350139</pqid></control><display><type>article</type><title>Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Burnett, W. D. ; Kontulainen, S. A. ; McLennan, C. E. ; Hunter, D. J. ; Wilson, D. R. ; Johnston, J. D.</creator><creatorcontrib>Burnett, W. D. ; Kontulainen, S. A. ; McLennan, C. E. ; Hunter, D. J. ; Wilson, D. R. ; Johnston, J. D.</creatorcontrib><description>Summary
Computed tomography-based depth-specific image processing is able to precisely identify regional differences between healthy patellae and patellae with osteoarthritis.
Introduction
This study aims to assess the precision errors and potential differences in regional, depth-specific subchondral bone mineral density (BMD) in normal and osteoarthritic (OA) human patellae in vivo using CT-based density analyses.
Methods
Fourteen participants (2 men and 12 women; mean age, 51.4; SD, 11.8 years) were scanned using clinical quantitative CT (QCT) three times over 2 days. Participants were categorized as either normal (
n
= 7) or exhibiting radiographic OA (
n
= 7). Average subchondral BMD was assessed at three depths relative to the subchondral surface. Regional BMD analysis included: total lateral facet BMD, total medial facet BMD, and superior/middle/inferior BMD of lateral and medial facets at normalized depths of 0–2.5, 2.5–5, and 5–7.5 mm from the subchondral surface. We assessed precision using root mean square coefficients of variation (CV%). We evaluated differences between OA and normal BMD by (1) calculating percentage differences between the groups (in relation to normal BMD) (2) relating percentage differences to respective CV% errors and (3) determining effect sizes using Cohen’s
d
.
Results
Root mean square CV% precision errors ranged from 1.1 to 5.9 %. Percentage differences between OA and normal BMD varied from −1.6 to −30.1 % (BMD lower in OA patellae). In relation to precision errors, percentage differences were, on average, 5.5× greater than CV% errors. Cohen’s
d
effect sizes ranged from −1.7 to −0.1. Largest differences were noted at depths of 2.5–5 and 5–7.5 mm from the subchondral surface.
Conclusions
Patellar subchondral BMD measures were precise (average CV%, ≤3 %). This region- and depth-specific CT-based imaging tool characterized regional standardized BMD differences between normal and OA patellae in vivo.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-013-2568-2</identifier><identifier>PMID: 24221452</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adult ; Age ; Aged ; Arthritis ; Bone density ; Bone Density - physiology ; Bones ; Endocrinology ; Female ; Humans ; Knee ; Knee Joint - diagnostic imaging ; Knee Joint - physiopathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Orthopedics ; Osteoarthritis, Knee - diagnostic imaging ; Osteoarthritis, Knee - physiopathology ; Patella - diagnostic imaging ; Patella - physiology ; Patella - physiopathology ; Radiographic Image Interpretation, Computer-Assisted - methods ; Rheumatology ; Tomography ; Tomography, X-Ray Computed - methods ; Young Adult</subject><ispartof>Osteoporosis international, 2014-03, Vol.25 (3), p.1107-1114</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2013</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-7f96781f8febbdfa50c5967331333902325952baeeef65587f37c986e2de3fa33</citedby><cites>FETCH-LOGICAL-c405t-7f96781f8febbdfa50c5967331333902325952baeeef65587f37c986e2de3fa33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-013-2568-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-013-2568-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24221452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burnett, W. D.</creatorcontrib><creatorcontrib>Kontulainen, S. A.</creatorcontrib><creatorcontrib>McLennan, C. E.</creatorcontrib><creatorcontrib>Hunter, D. J.</creatorcontrib><creatorcontrib>Wilson, D. R.</creatorcontrib><creatorcontrib>Johnston, J. D.</creatorcontrib><title>Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
Computed tomography-based depth-specific image processing is able to precisely identify regional differences between healthy patellae and patellae with osteoarthritis.
Introduction
This study aims to assess the precision errors and potential differences in regional, depth-specific subchondral bone mineral density (BMD) in normal and osteoarthritic (OA) human patellae in vivo using CT-based density analyses.
Methods
Fourteen participants (2 men and 12 women; mean age, 51.4; SD, 11.8 years) were scanned using clinical quantitative CT (QCT) three times over 2 days. Participants were categorized as either normal (
n
= 7) or exhibiting radiographic OA (
n
= 7). Average subchondral BMD was assessed at three depths relative to the subchondral surface. Regional BMD analysis included: total lateral facet BMD, total medial facet BMD, and superior/middle/inferior BMD of lateral and medial facets at normalized depths of 0–2.5, 2.5–5, and 5–7.5 mm from the subchondral surface. We assessed precision using root mean square coefficients of variation (CV%). We evaluated differences between OA and normal BMD by (1) calculating percentage differences between the groups (in relation to normal BMD) (2) relating percentage differences to respective CV% errors and (3) determining effect sizes using Cohen’s
d
.
Results
Root mean square CV% precision errors ranged from 1.1 to 5.9 %. Percentage differences between OA and normal BMD varied from −1.6 to −30.1 % (BMD lower in OA patellae). In relation to precision errors, percentage differences were, on average, 5.5× greater than CV% errors. Cohen’s
d
effect sizes ranged from −1.7 to −0.1. Largest differences were noted at depths of 2.5–5 and 5–7.5 mm from the subchondral surface.
Conclusions
Patellar subchondral BMD measures were precise (average CV%, ≤3 %). This region- and depth-specific CT-based imaging tool characterized regional standardized BMD differences between normal and OA patellae in vivo.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Arthritis</subject><subject>Bone density</subject><subject>Bone Density - physiology</subject><subject>Bones</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Knee</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Joint - physiopathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Patella - diagnostic imaging</subject><subject>Patella - physiology</subject><subject>Patella - physiopathology</subject><subject>Radiographic Image Interpretation, Computer-Assisted - methods</subject><subject>Rheumatology</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Young Adult</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkd9q1UAQxhdR7Gn1AbyRgDfeRPdvNuudFLVCQRAF78Imme3ZkuzGnaTQl_CZndNTRQTxapmd3_fNMB9jzwR_JTi3r5Fz4dqaC1VL07S1fMB2QiuqXGMesh13ytZOi28n7BTxmpPGOfuYnUgtpdBG7tiPz3AVc_JTNcKy7mtcYIghDhVu_bDPaSzU6nMC6ieM6201g8etAFYxVRlXyL6s-xJX0vg0VimXmSSLX2GaPLw5YDfxJldLIWekWXcYVVOcY_LlthryvPgSMSd8wh4FPyE8vX_P2Nf3776cX9SXnz58PH97WQ-am7W2wTW2FaEN0Pdj8IYPhn6UEkopx6WSxhnZewAIjTGtDcoOrm1AjqCCV-qMvTz6LiV_3wDXbo44HDZOkDfshOFGaa05_z-qnROaN9wS-uIv9DpvhY57R1llKClHlDhSQ8mIBUK3lDjTITrBu0Ou3THXjujukGsnSfP83nnrZxh_K34FSYA8AkitdAXlj9H_dP0JvS-v6w</recordid><startdate>20140301</startdate><enddate>20140301</enddate><creator>Burnett, W. D.</creator><creator>Kontulainen, S. A.</creator><creator>McLennan, C. E.</creator><creator>Hunter, D. J.</creator><creator>Wilson, D. R.</creator><creator>Johnston, J. D.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140301</creationdate><title>Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons</title><author>Burnett, W. D. ; Kontulainen, S. A. ; McLennan, C. E. ; Hunter, D. J. ; Wilson, D. R. ; Johnston, J. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-7f96781f8febbdfa50c5967331333902325952baeeef65587f37c986e2de3fa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Arthritis</topic><topic>Bone density</topic><topic>Bone Density - physiology</topic><topic>Bones</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Knee</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Knee Joint - physiopathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Patella - diagnostic imaging</topic><topic>Patella - physiology</topic><topic>Patella - physiopathology</topic><topic>Radiographic Image Interpretation, Computer-Assisted - methods</topic><topic>Rheumatology</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burnett, W. D.</creatorcontrib><creatorcontrib>Kontulainen, S. A.</creatorcontrib><creatorcontrib>McLennan, C. E.</creatorcontrib><creatorcontrib>Hunter, D. J.</creatorcontrib><creatorcontrib>Wilson, D. R.</creatorcontrib><creatorcontrib>Johnston, J. D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burnett, W. D.</au><au>Kontulainen, S. A.</au><au>McLennan, C. E.</au><au>Hunter, D. J.</au><au>Wilson, D. R.</au><au>Johnston, J. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2014-03-01</date><risdate>2014</risdate><volume>25</volume><issue>3</issue><spage>1107</spage><epage>1114</epage><pages>1107-1114</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
Computed tomography-based depth-specific image processing is able to precisely identify regional differences between healthy patellae and patellae with osteoarthritis.
Introduction
This study aims to assess the precision errors and potential differences in regional, depth-specific subchondral bone mineral density (BMD) in normal and osteoarthritic (OA) human patellae in vivo using CT-based density analyses.
Methods
Fourteen participants (2 men and 12 women; mean age, 51.4; SD, 11.8 years) were scanned using clinical quantitative CT (QCT) three times over 2 days. Participants were categorized as either normal (
n
= 7) or exhibiting radiographic OA (
n
= 7). Average subchondral BMD was assessed at three depths relative to the subchondral surface. Regional BMD analysis included: total lateral facet BMD, total medial facet BMD, and superior/middle/inferior BMD of lateral and medial facets at normalized depths of 0–2.5, 2.5–5, and 5–7.5 mm from the subchondral surface. We assessed precision using root mean square coefficients of variation (CV%). We evaluated differences between OA and normal BMD by (1) calculating percentage differences between the groups (in relation to normal BMD) (2) relating percentage differences to respective CV% errors and (3) determining effect sizes using Cohen’s
d
.
Results
Root mean square CV% precision errors ranged from 1.1 to 5.9 %. Percentage differences between OA and normal BMD varied from −1.6 to −30.1 % (BMD lower in OA patellae). In relation to precision errors, percentage differences were, on average, 5.5× greater than CV% errors. Cohen’s
d
effect sizes ranged from −1.7 to −0.1. Largest differences were noted at depths of 2.5–5 and 5–7.5 mm from the subchondral surface.
Conclusions
Patellar subchondral BMD measures were precise (average CV%, ≤3 %). This region- and depth-specific CT-based imaging tool characterized regional standardized BMD differences between normal and OA patellae in vivo.</abstract><cop>London</cop><pub>Springer London</pub><pmid>24221452</pmid><doi>10.1007/s00198-013-2568-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-941X |
| ispartof | Osteoporosis international, 2014-03, Vol.25 (3), p.1107-1114 |
| issn | 0937-941X 1433-2965 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Age Aged Arthritis Bone density Bone Density - physiology Bones Endocrinology Female Humans Knee Knee Joint - diagnostic imaging Knee Joint - physiopathology Male Medicine Medicine & Public Health Middle Aged Original Article Orthopedics Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - physiopathology Patella - diagnostic imaging Patella - physiology Patella - physiopathology Radiographic Image Interpretation, Computer-Assisted - methods Rheumatology Tomography Tomography, X-Ray Computed - methods Young Adult |
| title | Regional depth-specific subchondral bone density measures in osteoarthritic and normal patellae: in vivo precision and preliminary comparisons |
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