A Chaperone-Assisted Degradation Pathway Targets Kinetochore Proteins to Ensure Genome Stability: e1004140

Cells are regularly exposed to stress conditions that may lead to protein misfolding. To cope with this challenge, molecular chaperones selectively target structurally perturbed proteins for degradation via the ubiquitin-proteasome pathway. In mammals the co-chaperone BAG-1 plays an important role i...

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Veröffentlicht in:	PLoS genetics 2014-01, Vol.10 (1)
Hauptverfasser:	Kriegenburg, Franziska, Jakopec, Visnja, Poulsen, Esben G, Nielsen, Sofie Vincents, Roguev, Assen, Krogan, Nevan, Gordon, Colin, Fleig, Ursula, Hartmann-Petersen, Rasmus
Format:	Artikel
Sprache:	eng
Schlagworte:	Chaperones Enzymes Genomes Genotype & phenotype Homeostasis Lasers Lectins Mammals Proteins Quality control Schizosaccharomyces pombe Temperature Yeast
Online-Zugang:	Volltext
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