Dietary fish oil reduces systemic inflammation and ameliorates sepsis-induced liver injury by up-regulating the peroxisome proliferator-activated receptor gamma-mediated pathway in septic mice

This study investigated the effect of dietary fish oil on systemic inflammation and hepatic injury in mice with polymicrobial sepsis. Male ICR mice were assigned to a control group (C, n=30) and a fish oil group (FO, n=30). Mice in the C group were fed a semi-purified diet with 10% soybean oil, and...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2014-01, Vol.25 (1), p.19-25
Hauptverfasser:	Li, Cheng-Chung, Yang, Hui-Ting, Hou, Yu-Chen, Chiu, Yen-Shuo, Chiu, Wan-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - blood Fatty Acids, Omega-3 - pharmacology Fish oil Fish Oils - administration & dosage Inducible nitric oxide synthase Inflammation - drug therapy Interleukin-10 - blood Interleukin-6 - blood Liver - drug effects Liver - injuries Liver Diseases - drug therapy Liver Diseases - etiology Male Mice Mice, Inbred ICR NF-kappa B - genetics NF-kappa B - metabolism NF-κB p65 Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Peroxidase - metabolism Peroxisome proliferators-activated receptor gamma PPAR gamma - genetics PPAR gamma - metabolism Sepsis Sepsis - complications Sepsis - drug therapy Tumor Necrosis Factor-alpha - blood Tyrosine - analogs & derivatives Tyrosine - metabolism Up-Regulation
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