Immunomodulatory activities of polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla
•Polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla.•The average molecular weights were analyzed by Sepharose CL-6B column.•Monosaccharide composition of polysaccharide fractions were analyzed by GLC.•Amino acids of polysaccharide fractions were analyzed by amino acid analyser...
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| Veröffentlicht in: | Carbohydrate polymers 2013-11, Vol.98 (2), p.1458-1465 |
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| creator | Zhang, Lin Koyyalamudi, Sundar Rao Jeong, Sang Chul Reddy, Narsimha Bailey, Trevor Longvah, T. |
| description | •Polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla.•The average molecular weights were analyzed by Sepharose CL-6B column.•Monosaccharide composition of polysaccharide fractions were analyzed by GLC.•Amino acids of polysaccharide fractions were analyzed by amino acid analyser.•Immunomodulatory and antioxidant activities of polysaccharides were measured.
Taxillus chinensis and Uncaria rhyncophylla are the herbs used in traditional Chinese anticancer formulations. During the past decade, research on plant polysaccharides has gained importance due to their therapeutic value and minimum side effects. In this study, hot water extraction method was employed to isolate polysaccharides from the stems of T. chinensis and stems with hooks of U. rhyncophylla. Size-exclusion chromatography was then used for further fractionation. Separated fractions from T. chinensis were designated as TCP-1, TCP-2 and TCP-3 and those from U. rhyncophylla were termed UC-1 and UC-2. Their sugar compositions were estimated using gas chromatography that revealed the presence fructose, glucose, xylose, arbinose, and rhamnose. Amino acid analysis of these fractions has indicated that they are protein-bound polysaccharides. The antioxidant activities were investigated using DPPH and yeast assays. The ability of these polysaccharide fractions to stimulate mouse macrophages was measured using Griess reagent and ELISA test. The results revealed that some of the isolated fractions (TCP-2, TCP-3, UC-1 and UC-2) displayed significant antioxidant activities and were also found to be effective immunomodulators in a concentration-dependent manner. Outcomes of this research strongly indicate that U. rhyncophylla and T. chinensis have therapeutic potential to be used for the treatment of cancer. |
| doi_str_mv | 10.1016/j.carbpol.2013.07.060 |
| format | Article |
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Taxillus chinensis and Uncaria rhyncophylla are the herbs used in traditional Chinese anticancer formulations. During the past decade, research on plant polysaccharides has gained importance due to their therapeutic value and minimum side effects. In this study, hot water extraction method was employed to isolate polysaccharides from the stems of T. chinensis and stems with hooks of U. rhyncophylla. Size-exclusion chromatography was then used for further fractionation. Separated fractions from T. chinensis were designated as TCP-1, TCP-2 and TCP-3 and those from U. rhyncophylla were termed UC-1 and UC-2. Their sugar compositions were estimated using gas chromatography that revealed the presence fructose, glucose, xylose, arbinose, and rhamnose. Amino acid analysis of these fractions has indicated that they are protein-bound polysaccharides. The antioxidant activities were investigated using DPPH and yeast assays. The ability of these polysaccharide fractions to stimulate mouse macrophages was measured using Griess reagent and ELISA test. The results revealed that some of the isolated fractions (TCP-2, TCP-3, UC-1 and UC-2) displayed significant antioxidant activities and were also found to be effective immunomodulators in a concentration-dependent manner. Outcomes of this research strongly indicate that U. rhyncophylla and T. chinensis have therapeutic potential to be used for the treatment of cancer.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2013.07.060</identifier><identifier>PMID: 24053827</identifier><identifier>CODEN: CAPOD8</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>adverse effects ; amino acid composition ; Animals ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Antioxidant activities ; antioxidant activity ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Applied sciences ; Biological and medical sciences ; Cell Line ; Cell Line, Tumor ; Chromatography, Gel ; Drugs, Chinese Herbal - chemistry ; enzyme-linked immunosorbent assay ; Exact sciences and technology ; fractionation ; fructose ; gas chromatography ; gel chromatography ; glucose ; herbs ; Hot Temperature ; Immunologic Factors - chemistry ; Immunologic Factors - isolation & purification ; Immunologic Factors - pharmacology ; immunomodulation ; Immunomodulators ; Immunomodulatory effects ; Loranthaceae - chemistry ; Macrophage Activation - drug effects ; macrophages ; Macrophages - cytology ; Macrophages - drug effects ; Medical sciences ; Mice ; Monosaccharides - chemistry ; Natural polymers ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Plant Extracts - chemistry ; Plant Stems - chemistry ; Polysaccharides ; Polysaccharides - chemistry ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; rhamnose ; Solvents ; Starch and polysaccharides ; stems ; T. chinensis ; Taxillus ; U. rhyncophylla ; Uncaria ; Uncaria - chemistry ; Water ; xylose ; yeasts</subject><ispartof>Carbohydrate polymers, 2013-11, Vol.98 (2), p.1458-1465</ispartof><rights>2013 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-c3b22e47cecc9e6d80cfd1db6deb0dbab7c5a603c63d06a67c7926365cbaa1d13</citedby><cites>FETCH-LOGICAL-c452t-c3b22e47cecc9e6d80cfd1db6deb0dbab7c5a603c63d06a67c7926365cbaa1d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2013.07.060$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27798352$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24053827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Koyyalamudi, Sundar Rao</creatorcontrib><creatorcontrib>Jeong, Sang Chul</creatorcontrib><creatorcontrib>Reddy, Narsimha</creatorcontrib><creatorcontrib>Bailey, Trevor</creatorcontrib><creatorcontrib>Longvah, T.</creatorcontrib><title>Immunomodulatory activities of polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>•Polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla.•The average molecular weights were analyzed by Sepharose CL-6B column.•Monosaccharide composition of polysaccharide fractions were analyzed by GLC.•Amino acids of polysaccharide fractions were analyzed by amino acid analyser.•Immunomodulatory and antioxidant activities of polysaccharides were measured.
Taxillus chinensis and Uncaria rhyncophylla are the herbs used in traditional Chinese anticancer formulations. During the past decade, research on plant polysaccharides has gained importance due to their therapeutic value and minimum side effects. In this study, hot water extraction method was employed to isolate polysaccharides from the stems of T. chinensis and stems with hooks of U. rhyncophylla. Size-exclusion chromatography was then used for further fractionation. Separated fractions from T. chinensis were designated as TCP-1, TCP-2 and TCP-3 and those from U. rhyncophylla were termed UC-1 and UC-2. Their sugar compositions were estimated using gas chromatography that revealed the presence fructose, glucose, xylose, arbinose, and rhamnose. Amino acid analysis of these fractions has indicated that they are protein-bound polysaccharides. The antioxidant activities were investigated using DPPH and yeast assays. The ability of these polysaccharide fractions to stimulate mouse macrophages was measured using Griess reagent and ELISA test. The results revealed that some of the isolated fractions (TCP-2, TCP-3, UC-1 and UC-2) displayed significant antioxidant activities and were also found to be effective immunomodulators in a concentration-dependent manner. Outcomes of this research strongly indicate that U. rhyncophylla and T. chinensis have therapeutic potential to be used for the treatment of cancer.</description><subject>adverse effects</subject><subject>amino acid composition</subject><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antioxidant activities</subject><subject>antioxidant activity</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Chromatography, Gel</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>enzyme-linked immunosorbent assay</subject><subject>Exact sciences and technology</subject><subject>fractionation</subject><subject>fructose</subject><subject>gas chromatography</subject><subject>gel chromatography</subject><subject>glucose</subject><subject>herbs</subject><subject>Hot Temperature</subject><subject>Immunologic Factors - chemistry</subject><subject>Immunologic Factors - isolation & purification</subject><subject>Immunologic Factors - pharmacology</subject><subject>immunomodulation</subject><subject>Immunomodulators</subject><subject>Immunomodulatory effects</subject><subject>Loranthaceae - chemistry</subject><subject>Macrophage Activation - drug effects</subject><subject>macrophages</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Monosaccharides - chemistry</subject><subject>Natural polymers</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Stems - chemistry</subject><subject>Polysaccharides</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - isolation & purification</subject><subject>Polysaccharides - pharmacology</subject><subject>rhamnose</subject><subject>Solvents</subject><subject>Starch and polysaccharides</subject><subject>stems</subject><subject>T. chinensis</subject><subject>Taxillus</subject><subject>U. rhyncophylla</subject><subject>Uncaria</subject><subject>Uncaria - chemistry</subject><subject>Water</subject><subject>xylose</subject><subject>yeasts</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhq2Kql0KjwDkgsQlwY4dOzmhqmqhUiUOdM_WZOwQr5J4sZOKvD1edqHH-mLJ-mb-GX-EvGO0YJTJz7sCIbR7PxQlZbygqqCSnpENq1WTMy7EK7KhTIi8lkxdktcx7mg6ktELclkKWvG6VBvS34_jMvnRm2WA2Yc1A5zdk5udjZnvshSwRkDsITiTnlz0ibMm64Ifs0f47YZhiRn2brJTdDGDyWTbKc3mIAv9OqHf9-swwBty3sEQ7dvTfUW2d7ePN9_yh-9f72-uH3IUVTnnyNuytEKhRWysNDXFzjDTSmNbalpoFVYgKUfJDZUgFaqmlFxW2AIww_gV-XTsuw_-12LjrEcX0aYJJuuXqFmVVudNXdKXUcGrWgjZHLpWRxSDjzHYTu-DGyGsmlF98KF3-uRDH3xoqnTykerenyKWdrTmf9U_AQn4eAIgIgxdgAldfOaUampelYn7cOQ68Bp-hsRsf6QkmZxWXPyN-nIkbPrdJ2eDjujshNa4YHHWxrsXhv0DwTa31A</recordid><startdate>20131106</startdate><enddate>20131106</enddate><creator>Zhang, Lin</creator><creator>Koyyalamudi, Sundar Rao</creator><creator>Jeong, Sang Chul</creator><creator>Reddy, Narsimha</creator><creator>Bailey, Trevor</creator><creator>Longvah, T.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20131106</creationdate><title>Immunomodulatory activities of polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla</title><author>Zhang, Lin ; Koyyalamudi, Sundar Rao ; Jeong, Sang Chul ; Reddy, Narsimha ; Bailey, Trevor ; Longvah, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-c3b22e47cecc9e6d80cfd1db6deb0dbab7c5a603c63d06a67c7926365cbaa1d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>adverse effects</topic><topic>amino acid composition</topic><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antioxidant activities</topic><topic>antioxidant activity</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell Line, Tumor</topic><topic>Chromatography, Gel</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>enzyme-linked immunosorbent assay</topic><topic>Exact sciences and technology</topic><topic>fractionation</topic><topic>fructose</topic><topic>gas chromatography</topic><topic>gel chromatography</topic><topic>glucose</topic><topic>herbs</topic><topic>Hot Temperature</topic><topic>Immunologic Factors - chemistry</topic><topic>Immunologic Factors - isolation & purification</topic><topic>Immunologic Factors - pharmacology</topic><topic>immunomodulation</topic><topic>Immunomodulators</topic><topic>Immunomodulatory effects</topic><topic>Loranthaceae - chemistry</topic><topic>Macrophage Activation - drug effects</topic><topic>macrophages</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Monosaccharides - chemistry</topic><topic>Natural polymers</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Stems - chemistry</topic><topic>Polysaccharides</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - isolation & purification</topic><topic>Polysaccharides - pharmacology</topic><topic>rhamnose</topic><topic>Solvents</topic><topic>Starch and polysaccharides</topic><topic>stems</topic><topic>T. chinensis</topic><topic>Taxillus</topic><topic>U. rhyncophylla</topic><topic>Uncaria</topic><topic>Uncaria - chemistry</topic><topic>Water</topic><topic>xylose</topic><topic>yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Lin</creatorcontrib><creatorcontrib>Koyyalamudi, Sundar Rao</creatorcontrib><creatorcontrib>Jeong, Sang Chul</creatorcontrib><creatorcontrib>Reddy, Narsimha</creatorcontrib><creatorcontrib>Bailey, Trevor</creatorcontrib><creatorcontrib>Longvah, T.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Lin</au><au>Koyyalamudi, Sundar Rao</au><au>Jeong, Sang Chul</au><au>Reddy, Narsimha</au><au>Bailey, Trevor</au><au>Longvah, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory activities of polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2013-11-06</date><risdate>2013</risdate><volume>98</volume><issue>2</issue><spage>1458</spage><epage>1465</epage><pages>1458-1465</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>•Polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla.•The average molecular weights were analyzed by Sepharose CL-6B column.•Monosaccharide composition of polysaccharide fractions were analyzed by GLC.•Amino acids of polysaccharide fractions were analyzed by amino acid analyser.•Immunomodulatory and antioxidant activities of polysaccharides were measured.
Taxillus chinensis and Uncaria rhyncophylla are the herbs used in traditional Chinese anticancer formulations. During the past decade, research on plant polysaccharides has gained importance due to their therapeutic value and minimum side effects. In this study, hot water extraction method was employed to isolate polysaccharides from the stems of T. chinensis and stems with hooks of U. rhyncophylla. Size-exclusion chromatography was then used for further fractionation. Separated fractions from T. chinensis were designated as TCP-1, TCP-2 and TCP-3 and those from U. rhyncophylla were termed UC-1 and UC-2. Their sugar compositions were estimated using gas chromatography that revealed the presence fructose, glucose, xylose, arbinose, and rhamnose. Amino acid analysis of these fractions has indicated that they are protein-bound polysaccharides. The antioxidant activities were investigated using DPPH and yeast assays. The ability of these polysaccharide fractions to stimulate mouse macrophages was measured using Griess reagent and ELISA test. The results revealed that some of the isolated fractions (TCP-2, TCP-3, UC-1 and UC-2) displayed significant antioxidant activities and were also found to be effective immunomodulators in a concentration-dependent manner. Outcomes of this research strongly indicate that U. rhyncophylla and T. chinensis have therapeutic potential to be used for the treatment of cancer.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24053827</pmid><doi>10.1016/j.carbpol.2013.07.060</doi><tpages>8</tpages></addata></record> |
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| ispartof | Carbohydrate polymers, 2013-11, Vol.98 (2), p.1458-1465 |
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| subjects | adverse effects amino acid composition Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antioxidant activities antioxidant activity Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Applied sciences Biological and medical sciences Cell Line Cell Line, Tumor Chromatography, Gel Drugs, Chinese Herbal - chemistry enzyme-linked immunosorbent assay Exact sciences and technology fractionation fructose gas chromatography gel chromatography glucose herbs Hot Temperature Immunologic Factors - chemistry Immunologic Factors - isolation & purification Immunologic Factors - pharmacology immunomodulation Immunomodulators Immunomodulatory effects Loranthaceae - chemistry Macrophage Activation - drug effects macrophages Macrophages - cytology Macrophages - drug effects Medical sciences Mice Monosaccharides - chemistry Natural polymers Pharmacology. Drug treatments Physicochemistry of polymers Plant Extracts - chemistry Plant Stems - chemistry Polysaccharides Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology rhamnose Solvents Starch and polysaccharides stems T. chinensis Taxillus U. rhyncophylla Uncaria Uncaria - chemistry Water xylose yeasts |
| title | Immunomodulatory activities of polysaccharides isolated from Taxillus chinensis and Uncaria rhyncophylla |
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