Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans

Secreted aspartyl proteinases inhibition study of pepstatin A analogues modified in the P3, P2, and P2′ positions. The family of secreted aspartic proteinases is known as an important virulence factor of yeast infections by Candida albicans in particular, which is the most common fungal pathogen for...

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Veröffentlicht in:	Biochemical pharmacology 2013-04, Vol.85 (7), p.881-887
Hauptverfasser:	Cadicamo, Cosimo D., Mortier, Jérémie, Wolber, Gerhard, Hell, Marie, Heinrich, Ina E., Michel, Dana, Semlin, Lydia, Berger, Ursula, Korting, Hans C., Höltje, Hans-Dieter, Koksch, Beate, Borelli, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-virulence agent Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - chemistry aspartic proteinases Candida albicans Candida albicans - enzymology Candidapeptidase Drug Design drugs Fungal Proteins - antagonists & inhibitors Fungal Proteins - chemistry humans Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry isozymes Models, Molecular pathogens Pepstatin Pepstatins - chemical synthesis Pepstatins - chemistry Peptidomimetic proteinase inhibitors Secreted aspartic proteinases inhibition Structure-Activity Relationship virulence X-radiation yeasts
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