Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells

Transplantation of neural stem/progenitor cells (NPCs) in the lesioned brain is able to restore morphological and physiological alterations induced by different injuries. The local microenvironment created at the site of grafting and the communication between grafted and host cells are crucial in th...

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Veröffentlicht in:	Glia 2014-04, Vol.62 (4), p.623-638
Hauptverfasser:	Talaverón, Rocío, Matarredona, Esperanza R., de la Cruz, Rosa R., Macías, David, Gálvez, Victoria, Pastor, Angel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Animals, Newborn Antibodies, Monoclonal Antigens - metabolism astrocytes Axotomy Brain damage Brain Injuries - surgery Connexin 43 - metabolism connexin43 Gap Junctions - physiology Gap Junctions - ultrastructure Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism In Vitro Techniques microglia Microscopy, Immunoelectron Nerve Tissue Proteins - metabolism Neural Stem Cells - physiology Neural Stem Cells - transplantation Neuroglia - physiology Neuroglia - ultrastructure Proteoglycans - metabolism Rats Rats, Wistar Rodents subventricular zone Transplants & implants
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