Knockdown of Slingshot 2 (SSH2) serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt–Hogg–Dubé tumour suppressor gene (FLCN)

Birt–Hogg–Dubé (BHD) syndrome, is a dominantly inherited familial cancer syndrome associated with susceptibility to renal cell carcinoma (RCC) caused by inactivating mutations in the folliculin ( FLCN ) gene. The precise functions of the FLCN gene product are still under investigation but RCC from B...

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Veröffentlicht in:	Oncogene 2014-02, Vol.33 (8), p.956-965
Hauptverfasser:	Lu, X, Boora, U, Seabra, L, Rabai, E M, Fenton, J, Reiman, A, Nagy, Z, Maher, E R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1244 692/699/67/589/1588/1351 Actin Apoptosis Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Caspase 3 - metabolism Cell activation Cell Biology Cell cycle Cell death Cell Line, Tumor Cofilin Enzyme Activation Gene Knockdown Techniques Gene therapy Genes, Tumor Suppressor Genetic disorders Human Genetics Humans Internal Medicine Kidney cancer Kidney Neoplasms - enzymology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Medicine Medicine & Public Health Null cells Oncology original-article Pathogenesis Phosphatase Phosphoprotein Phosphatases - genetics Phosphorylation Proto-Oncogene Proteins - genetics Real-Time Polymerase Chain Reaction Renal cell carcinoma Serine Serine phosphatase siRNA Therapeutic targets Thyroid carcinoma Thyroid Neoplasms - enzymology Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Tumor cell lines Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumors
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