Piperonyl Butoxide Increases Oxidative Toxicity of Fenthion in the Brain of Oreochromis niloticus

ABSTRACT The present study was designed to understand the effects of piperonyl butoxide (PBO), modulator of cytochrome P450 (CYP 450), on the neurotoxicity of organophosphate pesticide fenthion in the brain of Oreochromis niloticus used as a model organism. Fish were exposed to one‐fourth of the LC5...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2014-02, Vol.28 (2), p.84-90
Hauptverfasser:	Üner, Nevin, Piner, Petek, Temiz, Özge
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Animals Brain Brain - drug effects Brain - enzymology Brain - metabolism Cichlids - metabolism Fenthion Fenthion - toxicity Fish Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism HSP70 Heat-Shock Proteins - metabolism Lipid Peroxidation - drug effects Oreochromis niloticus Oxidation-Reduction - drug effects Oxidative Stress Piperonyl Butoxide Piperonyl Butoxide - toxicity Thiobarbituric Acid Reactive Substances - metabolism Toxicity
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