Piperonyl Butoxide Increases Oxidative Toxicity of Fenthion in the Brain of Oreochromis niloticus
ABSTRACT The present study was designed to understand the effects of piperonyl butoxide (PBO), modulator of cytochrome P450 (CYP 450), on the neurotoxicity of organophosphate pesticide fenthion in the brain of Oreochromis niloticus used as a model organism. Fish were exposed to one‐fourth of the LC5...
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| Veröffentlicht in: | Journal of biochemical and molecular toxicology 2014-02, Vol.28 (2), p.84-90 |
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| container_title | Journal of biochemical and molecular toxicology |
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| creator | Üner, Nevin Piner, Petek Temiz, Özge |
| description | ABSTRACT
The present study was designed to understand the effects of piperonyl butoxide (PBO), modulator of cytochrome P450 (CYP 450), on the neurotoxicity of organophosphate pesticide fenthion in the brain of Oreochromis niloticus used as a model organism. Fish were exposed to one‐fourth of the LC50 value of fenthion (0.567 mg/L) and 0.5 mg/L PBO concentration for 24 h, 96 h, and 15 days. Glutathione (GSH)‐related antioxidant system, lipid peroxidation, stress proteins, and acetylcholinesterase (AchE) activity were investigated. Our results showed that PBO induced the neurotoxic effect of fenthion with increasing oxidative stress in long‐term exposure. GSH‐related antioxidant system might take a role in protecting the brain from these oxidative effects. PBO possibly inhibited the biotransformation of fenthion by inhibiting CYP 450; thereby preventing the brain from AChE inhibition in short‐term exposure. Changes in parameters indicated that PBO caused biphasic response by affecting CYP 450 in the brain of O. niloticus. |
| doi_str_mv | 10.1002/jbt.21539 |
| format | Article |
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The present study was designed to understand the effects of piperonyl butoxide (PBO), modulator of cytochrome P450 (CYP 450), on the neurotoxicity of organophosphate pesticide fenthion in the brain of Oreochromis niloticus used as a model organism. Fish were exposed to one‐fourth of the LC50 value of fenthion (0.567 mg/L) and 0.5 mg/L PBO concentration for 24 h, 96 h, and 15 days. Glutathione (GSH)‐related antioxidant system, lipid peroxidation, stress proteins, and acetylcholinesterase (AchE) activity were investigated. Our results showed that PBO induced the neurotoxic effect of fenthion with increasing oxidative stress in long‐term exposure. GSH‐related antioxidant system might take a role in protecting the brain from these oxidative effects. PBO possibly inhibited the biotransformation of fenthion by inhibiting CYP 450; thereby preventing the brain from AChE inhibition in short‐term exposure. Changes in parameters indicated that PBO caused biphasic response by affecting CYP 450 in the brain of O. niloticus.</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.21539</identifier><identifier>PMID: 24497177</identifier><identifier>CODEN: JBMTFQ</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Acetylcholinesterase ; Acetylcholinesterase - metabolism ; Animals ; Brain ; Brain - drug effects ; Brain - enzymology ; Brain - metabolism ; Cichlids - metabolism ; Fenthion ; Fenthion - toxicity ; Fish ; Glutathione - metabolism ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; Glutathione Transferase - metabolism ; HSP70 Heat-Shock Proteins - metabolism ; Lipid Peroxidation - drug effects ; Oreochromis niloticus ; Oxidation-Reduction - drug effects ; Oxidative Stress ; Piperonyl Butoxide ; Piperonyl Butoxide - toxicity ; Thiobarbituric Acid Reactive Substances - metabolism ; Toxicity</subject><ispartof>Journal of biochemical and molecular toxicology, 2014-02, Vol.28 (2), p.84-90</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><rights>Copyright © 2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3909-f11557ead50a0f3f05782e45fa0ee572461ea8fd5e7fb3e2219425460ff06c9a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.21539$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.21539$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24497177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Üner, Nevin</creatorcontrib><creatorcontrib>Piner, Petek</creatorcontrib><creatorcontrib>Temiz, Özge</creatorcontrib><title>Piperonyl Butoxide Increases Oxidative Toxicity of Fenthion in the Brain of Oreochromis niloticus</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J Biochem Mol Toxicol</addtitle><description>ABSTRACT
The present study was designed to understand the effects of piperonyl butoxide (PBO), modulator of cytochrome P450 (CYP 450), on the neurotoxicity of organophosphate pesticide fenthion in the brain of Oreochromis niloticus used as a model organism. Fish were exposed to one‐fourth of the LC50 value of fenthion (0.567 mg/L) and 0.5 mg/L PBO concentration for 24 h, 96 h, and 15 days. Glutathione (GSH)‐related antioxidant system, lipid peroxidation, stress proteins, and acetylcholinesterase (AchE) activity were investigated. Our results showed that PBO induced the neurotoxic effect of fenthion with increasing oxidative stress in long‐term exposure. GSH‐related antioxidant system might take a role in protecting the brain from these oxidative effects. PBO possibly inhibited the biotransformation of fenthion by inhibiting CYP 450; thereby preventing the brain from AChE inhibition in short‐term exposure. Changes in parameters indicated that PBO caused biphasic response by affecting CYP 450 in the brain of O. niloticus.</description><subject>Acetylcholinesterase</subject><subject>Acetylcholinesterase - metabolism</subject><subject>Animals</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Brain - metabolism</subject><subject>Cichlids - metabolism</subject><subject>Fenthion</subject><subject>Fenthion - toxicity</subject><subject>Fish</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - metabolism</subject><subject>Glutathione Transferase - metabolism</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Oreochromis niloticus</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative Stress</subject><subject>Piperonyl Butoxide</subject><subject>Piperonyl Butoxide - toxicity</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Toxicity</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uEzEUhS0Eon8seAFkiQ2baa_H9ni8JBFJiypStYEuLWdyrThMxqk9A83b4yalCzasfKzzHeteH0LeMzhnAOXFetGfl0xy_YocM9C6AFGx13sti6pScEROUloDgNRKviVHpRBaMaWOib3xW4yh27V0NPTh0S-RXnVNRJsw0Vm-297_QjrPVuP7HQ2OTrDrVz501He0XyEdRZtVNmYRQ7OKYeMT7Xwbet8M6Yy8cbZN-O75PCXfJ1_m48vieja9Gn--LhquQReOMSkV2qUEC447kKouUUhnAVGqMm-EtnZLicotOJYl06KUogLnoGq05afk0-HdbQwPA6be5DEabFvbYRiSYRIk57yu4f-o0JoxVesyox__QddhiF1e5IkSoATUIlMfnqlhscGl2Ua_sXFn_v5zBi4OwG_f4u7FZ2CeCjS5QLMv0HwdzfciJ4pDwqceH18SNv40leJKmvtvU3N7N54qMbk3P_gfKjubfg</recordid><startdate>201402</startdate><enddate>201402</enddate><creator>Üner, Nevin</creator><creator>Piner, Petek</creator><creator>Temiz, Özge</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>7ST</scope><scope>SOI</scope></search><sort><creationdate>201402</creationdate><title>Piperonyl Butoxide Increases Oxidative Toxicity of Fenthion in the Brain of Oreochromis niloticus</title><author>Üner, Nevin ; Piner, Petek ; Temiz, Özge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3909-f11557ead50a0f3f05782e45fa0ee572461ea8fd5e7fb3e2219425460ff06c9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetylcholinesterase</topic><topic>Acetylcholinesterase - metabolism</topic><topic>Animals</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Brain - metabolism</topic><topic>Cichlids - metabolism</topic><topic>Fenthion</topic><topic>Fenthion - toxicity</topic><topic>Fish</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - metabolism</topic><topic>Glutathione Transferase - metabolism</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Oreochromis niloticus</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Oxidative Stress</topic><topic>Piperonyl Butoxide</topic><topic>Piperonyl Butoxide - toxicity</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Üner, Nevin</creatorcontrib><creatorcontrib>Piner, Petek</creatorcontrib><creatorcontrib>Temiz, Özge</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Üner, Nevin</au><au>Piner, Petek</au><au>Temiz, Özge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Piperonyl Butoxide Increases Oxidative Toxicity of Fenthion in the Brain of Oreochromis niloticus</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J Biochem Mol Toxicol</addtitle><date>2014-02</date><risdate>2014</risdate><volume>28</volume><issue>2</issue><spage>84</spage><epage>90</epage><pages>84-90</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><coden>JBMTFQ</coden><abstract>ABSTRACT
The present study was designed to understand the effects of piperonyl butoxide (PBO), modulator of cytochrome P450 (CYP 450), on the neurotoxicity of organophosphate pesticide fenthion in the brain of Oreochromis niloticus used as a model organism. Fish were exposed to one‐fourth of the LC50 value of fenthion (0.567 mg/L) and 0.5 mg/L PBO concentration for 24 h, 96 h, and 15 days. Glutathione (GSH)‐related antioxidant system, lipid peroxidation, stress proteins, and acetylcholinesterase (AchE) activity were investigated. Our results showed that PBO induced the neurotoxic effect of fenthion with increasing oxidative stress in long‐term exposure. GSH‐related antioxidant system might take a role in protecting the brain from these oxidative effects. PBO possibly inhibited the biotransformation of fenthion by inhibiting CYP 450; thereby preventing the brain from AChE inhibition in short‐term exposure. Changes in parameters indicated that PBO caused biphasic response by affecting CYP 450 in the brain of O. niloticus.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24497177</pmid><doi>10.1002/jbt.21539</doi><tpages>7</tpages></addata></record> |
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| subjects | Acetylcholinesterase Acetylcholinesterase - metabolism Animals Brain Brain - drug effects Brain - enzymology Brain - metabolism Cichlids - metabolism Fenthion Fenthion - toxicity Fish Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism HSP70 Heat-Shock Proteins - metabolism Lipid Peroxidation - drug effects Oreochromis niloticus Oxidation-Reduction - drug effects Oxidative Stress Piperonyl Butoxide Piperonyl Butoxide - toxicity Thiobarbituric Acid Reactive Substances - metabolism Toxicity |
| title | Piperonyl Butoxide Increases Oxidative Toxicity of Fenthion in the Brain of Oreochromis niloticus |
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