Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11
Highlights • CXCR3 ligands, CXCL9, CXCL10, and CXCL11, can act as a genetic vaccine adjuvant. • CXCL11 is the strongest vaccine adjuvant among the three CXCR3 ligands. • CXCL11 enhances antigen-specific CD8 T cells responses and memory generation. • CXCL11 enhances vaccine-induced anti-tumor activit...
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| Veröffentlicht in: | Vaccine 2014-02, Vol.32 (10), p.1205-1212 |
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| container_end_page | 1212 |
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| container_issue | 10 |
| container_start_page | 1205 |
| container_title | Vaccine |
| container_volume | 32 |
| creator | Namkoong, Hong Song, Mi-Young Seo, Yong Bok Choi, Dong-Hoon Kim, Sae Won Im, Se Jin Sung, Young Chul Park, Yunji |
| description | Highlights • CXCR3 ligands, CXCL9, CXCL10, and CXCL11, can act as a genetic vaccine adjuvant. • CXCL11 is the strongest vaccine adjuvant among the three CXCR3 ligands. • CXCL11 enhances antigen-specific CD8 T cells responses and memory generation. • CXCL11 enhances vaccine-induced anti-tumor activities. |
| doi_str_mv | 10.1016/j.vaccine.2013.07.066 |
| format | Article |
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Psychology ; HEK293 Cells ; Human papillomavirus 16 ; Humans ; Immune system ; Immunity, Cellular ; Immunoglobulin Fc Fragments - genetics ; Immunoglobulin Fc Fragments - immunology ; Immunologic Memory ; Memory ; Mice ; Mice, Inbred C57BL ; Microbiology ; Neoplasms, Experimental - therapy ; Papillomavirus E7 Proteins - immunology ; Rodents ; Survival ; T cell receptors ; Vaccination ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral infections</subject><ispartof>Vaccine, 2014-02, Vol.32 (10), p.1205-1212</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. 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Psychology</subject><subject>HEK293 Cells</subject><subject>Human papillomavirus 16</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity, Cellular</subject><subject>Immunoglobulin Fc Fragments - genetics</subject><subject>Immunoglobulin Fc Fragments - immunology</subject><subject>Immunologic Memory</subject><subject>Memory</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>Neoplasms, Experimental - therapy</subject><subject>Papillomavirus E7 Proteins - immunology</subject><subject>Rodents</subject><subject>Survival</subject><subject>T cell receptors</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viral infections</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFksFu1DAQhi0EotvCI4AiIaReEjx2nDgXEAotIK3EgYJ6sxx7DF6yydZOVtq3x9EuVOqlJx_8zXh-f0PIK6AFUKjebYq9NsYPWDAKvKB1QavqCVmBrHnOBMinZEVZVeYl0Nszch7jhlIqODTPyRnjDZNlJVbk59XwWw8GtzhM2egyPUz-Fw553KHxzpus_SSzm8xg32cB424cIsasO2RmzC32fo_hsNRdm9zNEW3W3rZrgBfkmdN9xJen84L8uL66ab_k62-fv7Yf17kRAFPeWak5q4Q2oja16dCgZLwTaF1nZFcLzjUY56TrRM2FtbyuqbS60lY7SNcX5PLYdxfGuxnjpLY-LsPqAcc5KhApcsrcsMfRsmkgwVQm9M0DdDPOYUhBFkrSpgLaJEocKRPGGAM6tQt-q8NBAVWLI7VRJ0dqcaRorZKjVPf61H3utmj_V_2TkoC3J0BHo3sXkiAf7znJqjRBmbgPRw7TD-89BhWNxyTT-oBmUnb0j47y_kEH0_vBp0f_4AHjfWoVmaLq-7JQyz4Bp0AFa_hfdKjFBw</recordid><startdate>20140226</startdate><enddate>20140226</enddate><creator>Namkoong, Hong</creator><creator>Song, Mi-Young</creator><creator>Seo, Yong Bok</creator><creator>Choi, Dong-Hoon</creator><creator>Kim, Sae Won</creator><creator>Im, Se Jin</creator><creator>Sung, Young Chul</creator><creator>Park, Yunji</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140226</creationdate><title>Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11</title><author>Namkoong, Hong ; Song, Mi-Young ; Seo, Yong Bok ; Choi, Dong-Hoon ; Kim, Sae Won ; Im, Se Jin ; Sung, Young Chul ; Park, Yunji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-bd8a3265ac57c7cbece823b5edfbc8b7533a1cff8fb5735dd37708da6adaf1753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenoviridae</topic><topic>Adenovirus</topic><topic>Adjuvant</topic><topic>Adjuvants, Immunologic - genetics</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Cancer Vaccines - genetics</topic><topic>Cancer Vaccines - immunology</topic><topic>CD8 T cell</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cell Proliferation</topic><topic>Chemokine CXCL10 - genetics</topic><topic>Chemokine CXCL10 - immunology</topic><topic>Chemokine CXCL11 - genetics</topic><topic>Chemokine CXCL11 - immunology</topic><topic>Chemokine CXCL9 - genetics</topic><topic>Chemokine CXCL9 - immunology</topic><topic>CXCL11</topic><topic>Cytokines - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Namkoong, Hong</au><au>Song, Mi-Young</au><au>Seo, Yong Bok</au><au>Choi, Dong-Hoon</au><au>Kim, Sae Won</au><au>Im, Se Jin</au><au>Sung, Young Chul</au><au>Park, Yunji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2014-02-26</date><risdate>2014</risdate><volume>32</volume><issue>10</issue><spage>1205</spage><epage>1212</epage><pages>1205-1212</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Highlights • CXCR3 ligands, CXCL9, CXCL10, and CXCL11, can act as a genetic vaccine adjuvant. • CXCL11 is the strongest vaccine adjuvant among the three CXCR3 ligands. • CXCL11 enhances antigen-specific CD8 T cells responses and memory generation. • CXCL11 enhances vaccine-induced anti-tumor activities.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23928465</pmid><doi>10.1016/j.vaccine.2013.07.066</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2014-02, Vol.32 (10), p.1205-1212 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Adenoviridae Adenovirus Adjuvant Adjuvants, Immunologic - genetics Allergy and Immunology Animals Applied microbiology Biological and medical sciences Cancer Vaccines - genetics Cancer Vaccines - immunology CD8 T cell CD8-Positive T-Lymphocytes - immunology Cell Proliferation Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Chemokine CXCL11 - genetics Chemokine CXCL11 - immunology Chemokine CXCL9 - genetics Chemokine CXCL9 - immunology CXCL11 Cytokines - immunology Female Fundamental and applied biological sciences. Psychology HEK293 Cells Human papillomavirus 16 Humans Immune system Immunity, Cellular Immunoglobulin Fc Fragments - genetics Immunoglobulin Fc Fragments - immunology Immunologic Memory Memory Mice Mice, Inbred C57BL Microbiology Neoplasms, Experimental - therapy Papillomavirus E7 Proteins - immunology Rodents Survival T cell receptors Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral infections |
| title | Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11 |
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