Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state
ABSTRACT Several clinical reports on neuropathic pain of various etiologies have shown that it significantly interferes with sleep. Inadequate sleep due to neuropathic pain may contribute to the stressful negative consequences of living with pain. It is generally recognized that melatonin (MT) syste...
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| Veröffentlicht in: | Synapse (New York, N.Y.) N.Y.), 2014-04, Vol.68 (4), p.153-158 |
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| creator | Odo, Masahiko Koh, Keito Takada, Tomohiko Yamashita, Akira Narita, Michiko Kuzumaki, Naoko Ikegami, Daigo Sakai, Hiroyasu Iseki, Masako Inada, Eiichi Narita, Minoru |
| description | ABSTRACT
Several clinical reports on neuropathic pain of various etiologies have shown that it significantly interferes with sleep. Inadequate sleep due to neuropathic pain may contribute to the stressful negative consequences of living with pain. It is generally recognized that melatonin (MT) system in the hypothalmus is crusial for circadian rhythm and sleep‐wake transition. However, little, if any, is known about whether neuropathic pain could affect the MT system associated with sleep disturbance. In this study, we investigated the possible changes in circadian rhythm for the expression of MT receptors, especially MT1A and MT1B receptors, in the hypothalamus of mice with sciatic nerve ligation. The samples for real‐time RT‐PCR assay were prepared at 8:00, 14:00, 20:00, and 2:00 on day 7 after sciatic nerve ligation or sham operation. The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve‐ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness and a decrease in nonrapid eye movement sleep, was significantly greater than those in sham‐operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve‐ligated mice were significantly lower than those in sham‐operated mice. These findings suggest that neuropathic pain‐like stimuli lead to sleep disturbance in parallel with changes in circadian rhythm for mRNA expression of MT 1A and 1B receptors in the hypothalamus of mice. Synapse 68:153–158, 2014. © 2014 Wiley Periodicals, Inc.
The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve‐ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness, was significantly greater than those in sham‐operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve‐ligated mice were significantly lower than those in sham‐operated mice. |
| doi_str_mv | 10.1002/syn.21728 |
| format | Article |
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Several clinical reports on neuropathic pain of various etiologies have shown that it significantly interferes with sleep. Inadequate sleep due to neuropathic pain may contribute to the stressful negative consequences of living with pain. It is generally recognized that melatonin (MT) system in the hypothalmus is crusial for circadian rhythm and sleep‐wake transition. However, little, if any, is known about whether neuropathic pain could affect the MT system associated with sleep disturbance. In this study, we investigated the possible changes in circadian rhythm for the expression of MT receptors, especially MT1A and MT1B receptors, in the hypothalamus of mice with sciatic nerve ligation. The samples for real‐time RT‐PCR assay were prepared at 8:00, 14:00, 20:00, and 2:00 on day 7 after sciatic nerve ligation or sham operation. The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve‐ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness and a decrease in nonrapid eye movement sleep, was significantly greater than those in sham‐operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve‐ligated mice were significantly lower than those in sham‐operated mice. These findings suggest that neuropathic pain‐like stimuli lead to sleep disturbance in parallel with changes in circadian rhythm for mRNA expression of MT 1A and 1B receptors in the hypothalamus of mice. Synapse 68:153–158, 2014. © 2014 Wiley Periodicals, Inc.
The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve‐ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness, was significantly greater than those in sham‐operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve‐ligated mice were significantly lower than those in sham‐operated mice.</description><identifier>ISSN: 0887-4476</identifier><identifier>EISSN: 1098-2396</identifier><identifier>DOI: 10.1002/syn.21728</identifier><identifier>PMID: 24382790</identifier><identifier>CODEN: SYNAET</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Circadian Rhythm ; Circadian rhythms ; Hypothalamus - metabolism ; Male ; melatonin receptor ; Mice ; Mice, Inbred C57BL ; Neuralgia - metabolism ; Neuralgia - physiopathology ; neuropathic pain ; orexin receptor ; Receptor, Melatonin, MT1 - genetics ; Receptor, Melatonin, MT1 - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism</subject><ispartof>Synapse (New York, N.Y.), 2014-04, Vol.68 (4), p.153-158</ispartof><rights>Copyright © 2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4918-6025a56071bb0619897f5955ba2ee80f4cf72231e768ec295ce6c03c5761ed783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fsyn.21728$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fsyn.21728$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24382790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Odo, Masahiko</creatorcontrib><creatorcontrib>Koh, Keito</creatorcontrib><creatorcontrib>Takada, Tomohiko</creatorcontrib><creatorcontrib>Yamashita, Akira</creatorcontrib><creatorcontrib>Narita, Michiko</creatorcontrib><creatorcontrib>Kuzumaki, Naoko</creatorcontrib><creatorcontrib>Ikegami, Daigo</creatorcontrib><creatorcontrib>Sakai, Hiroyasu</creatorcontrib><creatorcontrib>Iseki, Masako</creatorcontrib><creatorcontrib>Inada, Eiichi</creatorcontrib><creatorcontrib>Narita, Minoru</creatorcontrib><title>Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state</title><title>Synapse (New York, N.Y.)</title><addtitle>Synapse</addtitle><description>ABSTRACT
Several clinical reports on neuropathic pain of various etiologies have shown that it significantly interferes with sleep. Inadequate sleep due to neuropathic pain may contribute to the stressful negative consequences of living with pain. It is generally recognized that melatonin (MT) system in the hypothalmus is crusial for circadian rhythm and sleep‐wake transition. However, little, if any, is known about whether neuropathic pain could affect the MT system associated with sleep disturbance. In this study, we investigated the possible changes in circadian rhythm for the expression of MT receptors, especially MT1A and MT1B receptors, in the hypothalamus of mice with sciatic nerve ligation. The samples for real‐time RT‐PCR assay were prepared at 8:00, 14:00, 20:00, and 2:00 on day 7 after sciatic nerve ligation or sham operation. The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve‐ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness and a decrease in nonrapid eye movement sleep, was significantly greater than those in sham‐operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve‐ligated mice were significantly lower than those in sham‐operated mice. These findings suggest that neuropathic pain‐like stimuli lead to sleep disturbance in parallel with changes in circadian rhythm for mRNA expression of MT 1A and 1B receptors in the hypothalamus of mice. Synapse 68:153–158, 2014. © 2014 Wiley Periodicals, Inc.
The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve‐ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness, was significantly greater than those in sham‐operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve‐ligated mice were significantly lower than those in sham‐operated mice.</description><subject>Animals</subject><subject>Circadian Rhythm</subject><subject>Circadian rhythms</subject><subject>Hypothalamus - metabolism</subject><subject>Male</subject><subject>melatonin receptor</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neuralgia - metabolism</subject><subject>Neuralgia - physiopathology</subject><subject>neuropathic pain</subject><subject>orexin receptor</subject><subject>Receptor, Melatonin, MT1 - genetics</subject><subject>Receptor, Melatonin, MT1 - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><issn>0887-4476</issn><issn>1098-2396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEokvhwB9AlrhwSeuP-Ou4rKAgVVsERYheLK93QtwmTmo7ovkH_Gyyu6WHXjjNSPO8r2bmLYrXBJ8QjOlpmsIJJZKqJ8WCYK1KyrR4WiywUrKsKimOihcpXWOMGcHV8-KIVkxRqfGi-LNqbPgFCfmAnI_Obr0NKDZTbjpU9xF1X9dLBHdDhJR8H1Bfow5am_swK8gS2bBF5D2K4GDIfdwb5QZQMw19bmxruzGhMWwhIosCjLEfbG68Q4P1oWz9DaCUbYaXxbPatgle3dfj4vvHD5erT-X5xdnn1fK8dJUmqhSYcssFlmSzwYJopWXNNecbSwEUritXS0oZASkUOKq5A-Ewc1wKAlup2HHx7uA7xP52hJRN55ODtrUB-jEZwjFnbH4m_z9aaU2YlmyHvn2EXvdjDPMhO0qSeeFKzNSbe2rcdLA1Q_SdjZP5F8cMnB6A376F6WFOsNnlbOaczT5n8-3net_MivKg8CnD3YPCxhsjJJPc_FifmSt1pb_IS27W7C-Ag6ho</recordid><startdate>201404</startdate><enddate>201404</enddate><creator>Odo, Masahiko</creator><creator>Koh, Keito</creator><creator>Takada, Tomohiko</creator><creator>Yamashita, Akira</creator><creator>Narita, Michiko</creator><creator>Kuzumaki, Naoko</creator><creator>Ikegami, Daigo</creator><creator>Sakai, Hiroyasu</creator><creator>Iseki, Masako</creator><creator>Inada, Eiichi</creator><creator>Narita, Minoru</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201404</creationdate><title>Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state</title><author>Odo, Masahiko ; Koh, Keito ; Takada, Tomohiko ; Yamashita, Akira ; Narita, Michiko ; Kuzumaki, Naoko ; Ikegami, Daigo ; Sakai, Hiroyasu ; Iseki, Masako ; Inada, Eiichi ; Narita, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4918-6025a56071bb0619897f5955ba2ee80f4cf72231e768ec295ce6c03c5761ed783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Circadian Rhythm</topic><topic>Circadian rhythms</topic><topic>Hypothalamus - metabolism</topic><topic>Male</topic><topic>melatonin receptor</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neuralgia - metabolism</topic><topic>Neuralgia - physiopathology</topic><topic>neuropathic pain</topic><topic>orexin receptor</topic><topic>Receptor, Melatonin, MT1 - genetics</topic><topic>Receptor, Melatonin, MT1 - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Odo, Masahiko</creatorcontrib><creatorcontrib>Koh, Keito</creatorcontrib><creatorcontrib>Takada, Tomohiko</creatorcontrib><creatorcontrib>Yamashita, Akira</creatorcontrib><creatorcontrib>Narita, Michiko</creatorcontrib><creatorcontrib>Kuzumaki, Naoko</creatorcontrib><creatorcontrib>Ikegami, Daigo</creatorcontrib><creatorcontrib>Sakai, Hiroyasu</creatorcontrib><creatorcontrib>Iseki, Masako</creatorcontrib><creatorcontrib>Inada, Eiichi</creatorcontrib><creatorcontrib>Narita, Minoru</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Synapse (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Odo, Masahiko</au><au>Koh, Keito</au><au>Takada, Tomohiko</au><au>Yamashita, Akira</au><au>Narita, Michiko</au><au>Kuzumaki, Naoko</au><au>Ikegami, Daigo</au><au>Sakai, Hiroyasu</au><au>Iseki, Masako</au><au>Inada, Eiichi</au><au>Narita, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state</atitle><jtitle>Synapse (New York, N.Y.)</jtitle><addtitle>Synapse</addtitle><date>2014-04</date><risdate>2014</risdate><volume>68</volume><issue>4</issue><spage>153</spage><epage>158</epage><pages>153-158</pages><issn>0887-4476</issn><eissn>1098-2396</eissn><coden>SYNAET</coden><abstract>ABSTRACT
Several clinical reports on neuropathic pain of various etiologies have shown that it significantly interferes with sleep. Inadequate sleep due to neuropathic pain may contribute to the stressful negative consequences of living with pain. It is generally recognized that melatonin (MT) system in the hypothalmus is crusial for circadian rhythm and sleep‐wake transition. However, little, if any, is known about whether neuropathic pain could affect the MT system associated with sleep disturbance. In this study, we investigated the possible changes in circadian rhythm for the expression of MT receptors, especially MT1A and MT1B receptors, in the hypothalamus of mice with sciatic nerve ligation. The samples for real‐time RT‐PCR assay were prepared at 8:00, 14:00, 20:00, and 2:00 on day 7 after sciatic nerve ligation or sham operation. The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve‐ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness and a decrease in nonrapid eye movement sleep, was significantly greater than those in sham‐operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve‐ligated mice were significantly lower than those in sham‐operated mice. These findings suggest that neuropathic pain‐like stimuli lead to sleep disturbance in parallel with changes in circadian rhythm for mRNA expression of MT 1A and 1B receptors in the hypothalamus of mice. Synapse 68:153–158, 2014. © 2014 Wiley Periodicals, Inc.
The mRNA expression of MT1A and MT1B receptors at 2:00 in sciatic nerve‐ligated mice, which exhibited thermal hyperalgesia along with an increase in wakefulness, was significantly greater than those in sham‐operated mice, whereas the levels of both MT1A and MT1B receptors at 8:00 in sciatic nerve‐ligated mice were significantly lower than those in sham‐operated mice.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24382790</pmid><doi>10.1002/syn.21728</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Circadian Rhythm Circadian rhythms Hypothalamus - metabolism Male melatonin receptor Mice Mice, Inbred C57BL Neuralgia - metabolism Neuralgia - physiopathology neuropathic pain orexin receptor Receptor, Melatonin, MT1 - genetics Receptor, Melatonin, MT1 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism |
| title | Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state |
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