High resolution melting curve assay for rapid detection of drug-resistant Mycobacterium tuberculosis

Abstract We developed and evaluated a high resolution melting (HRM) curve assay by using real-time PCR for the detection of the most frequent mutations of Mycobacterium tuberculosis , which are responsible for the resistance of four anti-TB drugs: rifampicin, isoniazid, ethambutol, and streptomycin....

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Veröffentlicht in:	Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2013-12, Vol.19 (6), p.1116-1125
Hauptverfasser:	Nagai, Yuhki, Iwade, Yoshito, Katayama, Masahiko, Yamaguchi, Tetsuo, Hayakawa, Eri, Nakano, Manabu, Sakai, Takashi, Mitarai, Satoshi, Nosaka, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - pharmacology DNA, Bacterial - analysis DNA, Bacterial - genetics Drug resistance Drug Resistance, Bacterial - genetics Hematology, Oncology and Palliative Medicine High resolution melting (HRM) analysis Humans Infectious Diseases Medical Microbiology Medicine Medicine & Public Health Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Original Article Real-Time Polymerase Chain Reaction - methods Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - microbiology Virology
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