Autophagy Reduces Neuronal Damage and Promotes Locomotor Recovery via Inhibition of Apoptosis After Spinal Cord Injury in Rats

Autophagy is an intracellular catabolic mechanism that maintains the balance of proteins, lipids and aging organelles. 3-Methyladenine (3-MA) is a selective inhibitor of autophagy, whereas rapamycin, an antifungal agent, is a specific inducer of autophagy, inhibiting the protein mammalian target of...

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Veröffentlicht in:	Molecular neurobiology 2014-02, Vol.49 (1), p.276-287
Hauptverfasser:	Tang, Peifu, Hou, Hongping, Zhang, Licheng, Lan, Xia, Mao, Zhi, Liu, Daohong, He, Chunqing, Du, Hailong, Zhang, Lihai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Autophagy Autophagy - drug effects Autophagy - physiology Biomedical and Life Sciences Biomedicine Cell Biology Male Motor Activity - drug effects Motor Activity - physiology Neurobiology Neurology Neurons Neurons - drug effects Neurons - pathology Neurosciences Rats Rats, Sprague-Dawley Recovery of Function - drug effects Recovery of Function - physiology Sirolimus - pharmacology Sirolimus - therapeutic use Spinal cord injuries Spinal Cord Injuries - pathology Spinal Cord Injuries - prevention & control Thoracic Vertebrae
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